6TD5
Leishmania tarentolae proteasome 20S subunit complexed with LXE408 and bortezomib
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Class II glutamine amidotransferases | 8101751 | 3000131 | SCOP2B (2022-06-29) |
O [auth a] | SCOP2 Family | Proteasome subunits | 8101750 | 4002254 | SCOP2 (2022-06-29) |
O [auth a] | SCOP2 Superfamily | Class II glutamine amidotransferases | 8101751 | 3000131 | SCOP2 (2022-06-29) |
L | SCOP2B Superfamily | Class II glutamine amidotransferases | 8101271 | 3000131 | SCOP2B (2022-06-29) |
Z [auth l] | SCOP2B Superfamily | Class II glutamine amidotransferases | 8101271 | 3000131 | SCOP2B (2022-06-29) |
M | SCOP2B Superfamily | Class II glutamine amidotransferases | 8101277 | 3000131 | SCOP2B (2022-06-29) |
AA [auth m] | SCOP2 Family | Proteasome subunits | 8101276 | 4002254 | SCOP2 (2022-06-29) |
AA [auth m] | SCOP2 Superfamily | Class II glutamine amidotransferases | 8101277 | 3000131 | SCOP2 (2022-06-29) |
B | SCOP2B Superfamily | Class II glutamine amidotransferases | 8101267 | 3000131 | SCOP2B (2022-06-29) |
P [auth b] | SCOP2 Family | Proteasome subunits | 8101266 | 4002254 | SCOP2 (2022-06-29) |
P [auth b] | SCOP2 Superfamily | Class II glutamine amidotransferases | 8101267 | 3000131 | SCOP2 (2022-06-29) |
C | SCOP2 Family | Proteasome subunits | 8101294 | 4002254 | SCOP2 (2022-06-29) |
C | SCOP2 Superfamily | Class II glutamine amidotransferases | 8101295 | 3000131 | SCOP2 (2022-06-29) |
Q [auth c] | SCOP2B Superfamily | Class II glutamine amidotransferases | 8101295 | 3000131 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Class II glutamine amidotransferases | 8101293 | 3000131 | SCOP2B (2022-06-29) |
R [auth d] | SCOP2 Family | Proteasome subunits | 8101292 | 4002254 | SCOP2 (2022-06-29) |
R [auth d] | SCOP2 Superfamily | Class II glutamine amidotransferases | 8101293 | 3000131 | SCOP2 (2022-06-29) |
S [auth e] | SCOP2B Superfamily | Class II glutamine amidotransferases | 8101269 | 3000131 | SCOP2B (2022-06-29) |
E | SCOP2 Family | Proteasome subunits | 8101268 | 4002254 | SCOP2 (2022-06-29) |
E | SCOP2 Superfamily | Class II glutamine amidotransferases | 8101269 | 3000131 | SCOP2 (2022-06-29) |
T [auth f] | SCOP2 Family | Proteasome subunits | 8101290 | 4002254 | SCOP2 (2022-06-29) |
T [auth f] | SCOP2 Superfamily | Class II glutamine amidotransferases | 8101291 | 3000131 | SCOP2 (2022-06-29) |
F | SCOP2B Superfamily | Class II glutamine amidotransferases | 8101291 | 3000131 | SCOP2B (2022-06-29) |
G | SCOP2B Superfamily | Class II glutamine amidotransferases | 8101275 | 3000131 | SCOP2B (2022-06-29) |
U [auth g] | SCOP2 Family | Proteasome subunits | 8101274 | 4002254 | SCOP2 (2022-06-29) |
U [auth g] | SCOP2 Superfamily | Class II glutamine amidotransferases | 8101275 | 3000131 | SCOP2 (2022-06-29) |
H | SCOP2B Superfamily | Class II glutamine amidotransferases | 8101289 | 3000131 | SCOP2B (2022-06-29) |
V [auth h] | SCOP2 Family | Proteasome subunits | 8101288 | 4002254 | SCOP2 (2022-06-29) |
V [auth h] | SCOP2 Superfamily | Class II glutamine amidotransferases | 8101289 | 3000131 | SCOP2 (2022-06-29) |
I | SCOP2 Family | Proteasome subunits | 8101272 | 4002254 | SCOP2 (2022-06-29) |
I | SCOP2 Superfamily | Class II glutamine amidotransferases | 8101273 | 3000131 | SCOP2 (2022-06-29) |
W [auth i] | SCOP2B Superfamily | Class II glutamine amidotransferases | 8101273 | 3000131 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF00227,PF10584 | e6td5A1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227,PF10584 | ECOD (1.6) |
O [auth a] | PF00227,PF10584 | e6td5a1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227,PF10584 | ECOD (1.6) |
J | PF00227 | e6td5J1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227 | ECOD (1.6) |
X [auth j] | PF00227 | e6td5j1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227 | ECOD (1.6) |
K | PF00227 | e6td5K1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227 | ECOD (1.6) |
Y [auth k] | PF00227 | e6td5k1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227 | ECOD (1.6) |
L | PF00227 | e6td5L1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227 | ECOD (1.6) |
Z [auth l] | PF00227 | e6td5l1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227 | ECOD (1.6) |
M | PF00227 | e6td5M1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227 | ECOD (1.6) |
AA [auth m] | PF00227 | e6td5m1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227 | ECOD (1.6) |
BA [auth n] | PF00227 | e6td5n1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227 | ECOD (1.6) |
N | PF00227 | e6td5N1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227 | ECOD (1.6) |
B | PF00227,PF10584 | e6td5B1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227,PF10584 | ECOD (1.6) |
P [auth b] | PF00227,PF10584 | e6td5b1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227,PF10584 | ECOD (1.6) |
C | PF00227,PF10584 | e6td5C1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227,PF10584 | ECOD (1.6) |
Q [auth c] | PF00227,PF10584 | e6td5c1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227,PF10584 | ECOD (1.6) |
D | PF00227,PF10584 | e6td5D1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227,PF10584 | ECOD (1.6) |
R [auth d] | PF00227,PF10584 | e6td5d1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227,PF10584 | ECOD (1.6) |
S [auth e] | PF00227,PF10584 | e6td5e1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227,PF10584 | ECOD (1.6) |
E | PF00227,PF10584 | e6td5E1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227,PF10584 | ECOD (1.6) |
T [auth f] | PF00227,PF10584 | e6td5f1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227,PF10584 | ECOD (1.6) |
F | PF00227,PF10584 | e6td5F1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227,PF10584 | ECOD (1.6) |
G | PF00227,PF10584 | e6td5G1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227,PF10584 | ECOD (1.6) |
U [auth g] | PF00227,PF10584 | e6td5g1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227,PF10584 | ECOD (1.6) |
I | PF00227 | e6td5I1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227 | ECOD (1.6) |
W [auth i] | PF00227 | e6td5i1 | A: a+b four layers | X: Ntn/PP2C | H: Ntn | T: Proteasome subunits | F: PF00227 | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A, O [auth a] | PF00227 | Proteasome subunit (Proteasome) | Proteasome subunit | The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ... | Domain |
A, O [auth a] | PF10584 | Proteasome subunit A N-terminal signature (Proteasome_A_N) | Proteasome subunit A N-terminal signature | - | Family |
J, X [auth j] | PF00227 | Proteasome subunit (Proteasome) | Proteasome subunit | The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ... | Domain |
K, Y [auth k] | PF00227 | Proteasome subunit (Proteasome) | Proteasome subunit | The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ... | Domain |
L, Z [auth l] | PF00227 | Proteasome subunit (Proteasome) | Proteasome subunit | The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ... | Domain |
AA [auth m], M | PF00227 | Proteasome subunit (Proteasome) | Proteasome subunit | The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ... | Domain |
BA [auth n], N | PF00227 | Proteasome subunit (Proteasome) | Proteasome subunit | The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ... | Domain |
B, P [auth b] | PF00227 | Proteasome subunit (Proteasome) | Proteasome subunit | The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ... | Domain |
B, P [auth b] | PF10584 | Proteasome subunit A N-terminal signature (Proteasome_A_N) | Proteasome subunit A N-terminal signature | - | Family |
C, Q [auth c] | PF00227 | Proteasome subunit (Proteasome) | Proteasome subunit | The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ... | Domain |
C, Q [auth c] | PF10584 | Proteasome subunit A N-terminal signature (Proteasome_A_N) | Proteasome subunit A N-terminal signature | - | Family |
D, R [auth d] | PF00227 | Proteasome subunit (Proteasome) | Proteasome subunit | The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ... | Domain |
D, R [auth d] | PF10584 | Proteasome subunit A N-terminal signature (Proteasome_A_N) | Proteasome subunit A N-terminal signature | - | Family |
E, S [auth e] | PF00227 | Proteasome subunit (Proteasome) | Proteasome subunit | The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ... | Domain |
E, S [auth e] | PF10584 | Proteasome subunit A N-terminal signature (Proteasome_A_N) | Proteasome subunit A N-terminal signature | - | Family |
F, T [auth f] | PF00227 | Proteasome subunit (Proteasome) | Proteasome subunit | The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ... | Domain |
F, T [auth f] | PF10584 | Proteasome subunit A N-terminal signature (Proteasome_A_N) | Proteasome subunit A N-terminal signature | - | Family |
G, U [auth g] | PF00227 | Proteasome subunit (Proteasome) | Proteasome subunit | The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ... | Domain |
G, U [auth g] | PF10584 | Proteasome subunit A N-terminal signature (Proteasome_A_N) | Proteasome subunit A N-terminal signature | - | Family |
H, V [auth h] | PF00227 | Proteasome subunit (Proteasome) | Proteasome subunit | The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ... | Domain |
I, W [auth i] | PF00227 | Proteasome subunit (Proteasome) | Proteasome subunit | The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ... | Domain |