6SEH
Recognition and processing of branched DNA substrates by Slx1-Slx4 nuclease
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
C [auth A] | PF01541 | e6sehA2 | A: a+b three layers | X: GIY-YIG endonuclease (From Topology) | H: GIY-YIG endonuclease (From Topology) | T: GIY-YIG endonuclease | F: PF01541 | ECOD (1.6) |
C [auth A] | PF21202 | e6sehA1 | A: few secondary structure elements | X: RING/U-box-like | H: RING/U-box-like | T: RING/U-box | F: PF21202 | ECOD (1.6) |
A [auth C] | PF01541 | e6sehC2 | A: a+b three layers | X: GIY-YIG endonuclease (From Topology) | H: GIY-YIG endonuclease (From Topology) | T: GIY-YIG endonuclease | F: PF01541 | ECOD (1.6) |
A [auth C] | PF21202 | e6sehC1 | A: few secondary structure elements | X: RING/U-box-like | H: RING/U-box-like | T: RING/U-box | F: PF21202 | ECOD (1.6) |
B [auth D] | PF09494 | e6sehD1 | A: alpha arrays | X: HTH | H: HTH | T: tri-helical | F: PF09494 | ECOD (1.6) |
D [auth B] | PF09494 | e6sehB1 | A: alpha arrays | X: HTH | H: HTH | T: tri-helical | F: PF09494 | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth C], C [auth A] | PF21202 | Structure-specific endonuclease subunit SLX1, C-terminal (SLX1_C) | Structure-specific endonuclease subunit SLX1, C-terminal | Slx1 is a catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. It has endonuclease activity towards branched DNA substrates, introducing single-strand ... | Domain |
B [auth D], D [auth B] | PF09494 | Slx4 endonuclease (Slx4) | Slx4 endonuclease | The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearin ... | Domain |