6R4N

Crystal structure of S. cerevisia Niemann-Pick type C protein NPC2 with ergosterol bound

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
I	PF02221	e6r4nI1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02221	ECOD (1.6)
A	PF02221	e6r4nA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02221	ECOD (1.6)
B	PF02221	e6r4nB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02221	ECOD (1.6)
C	PF02221	e6r4nC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02221	ECOD (1.6)
D	PF02221	e6r4nD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02221	ECOD (1.6)
E	PF02221	e6r4nE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02221	ECOD (1.6)
F	PF02221	e6r4nF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02221	ECOD (1.6)
G	PF02221	e6r4nG1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02221	ECOD (1.6)
H	PF02221	e6r4nH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02221	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I	PF02221	ML domain (E1_DerP2_DerF2)	ML domain	ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2 (Swiss:P49278). It has been implicate in lipid recognition, particularly in the recognition of pa ...	ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2 (Swiss:P49278). It has been implicate in lipid recognition, particularly in the recognition of pathogen related products. A mutation in Npc2 (Swiss:Q15668) causes a rare form of Niemann-Pick type C2 disease. This domain has a similar topology to immunoglobulin domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I	Phosphatidylglycerol/phosphatidylinositol transfer protein	sterol binding binding organic cyclic compound binding steroid binding lipid binding	cellular localization transport intracellular lipid transport organic substance transport lipid localization lipid transport intracellular transport organic hydroxy compound transport intracellular sterol transport establishment of localization localization macromolecule localization establishment of localization in cell cellular process cellular localization transport intracellular lipid transport organic substance transport lipid localization lipid transport intracellular transport organic hydroxy compound transport intracellular sterol transport establishment of localization localization macromolecule localization establishment of localization in cell cellular process sterol transport	membrane-bounded organelle storage vacuole intracellular anatomical structure lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle organelle cytoplasm membrane-enclosed lumen vacuolar lumen intracellular organelle lumen membrane-bounded organelle storage vacuole intracellular anatomical structure lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle organelle cytoplasm membrane-enclosed lumen vacuolar lumen intracellular organelle lumen organelle lumen fungal-type vacuole lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR039670	Sterol transport protein NPC2-like	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR036846	GM2-AP, lipid-recognition domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR033917	ML domain, phosphatidylinositol/phosphatidylglycerol transfer protein	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR003172	MD-2-related lipid-recognition domain	Domain

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D, E A, B, C, D, E, F, G, H, I	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Sterol-Sensing Domain (SSD) Proteins	Niemann-Pick type C protein NCR1

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.