Annotations: 6QPC

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF04547,PF16178	e6qpcA1	A: alpha bundles	X: TMEM16 lipid scramblase transmembrane domain (From Topology)	H: TMEM16 lipid scramblase transmembrane domain (From Topology)	T: TMEM16 lipid scramblase transmembrane domain	F: PF04547,PF16178	ECOD (1.6)
B	PF04547,PF16178	e6qpcB1	A: alpha bundles	X: TMEM16 lipid scramblase transmembrane domain (From Topology)	H: TMEM16 lipid scramblase transmembrane domain (From Topology)	T: TMEM16 lipid scramblase transmembrane domain	F: PF04547,PF16178	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF16178	Anoctamin, dimerisation domain (Anoct_dimer)	Anoctamin, dimerisation domain	This entry represents the dimerisation domain of anoctamin family of proteins. Seven members can be divided into two subfamilies; Ca2-dependent Cl(-) channels (TMEM16A and 16B) and Ca2-dependent lipid scramblases (TMEM16C, 16D, 16F, 16G, and 16J). Th ...	This entry represents the dimerisation domain of anoctamin family of proteins. Seven members can be divided into two subfamilies; Ca2-dependent Cl(-) channels (TMEM16A and 16B) and Ca2-dependent lipid scramblases (TMEM16C, 16D, 16F, 16G, and 16J). This domain is responsible for creating the homodimeric architecture of the chloride-channel proteins.	Domain
A, B	PF04547	Calcium-activated chloride channel (Anoctamin)	Calcium-activated chloride channel	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Anoctamin-6	monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity monoatomic ion channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity monoatomic anion channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity inorganic anion transmembrane transporter activity chloride channel activity identical protein binding protein binding monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity monoatomic ion channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity monoatomic anion channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity inorganic anion transmembrane transporter activity chloride channel activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity lipid transporter activity intramembrane lipid transporter activity phospholipid scramblase activity phospholipid transporter activity gated channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity intracellularly calcium-gated channel activity intracellularly calcium-gated chloride channel activity ligand-gated monoatomic anion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation transmembrane transporter activity calcium-activated cation channel activity monoatomic ion-gated channel activity monoatomic cation channel activity ligand-gated monoatomic cation channel activity cation binding ion binding metal ion binding small molecule binding	multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding cellular component organization cellular component biogenesis bleb assembly multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding cellular component organization cellular component biogenesis bleb assembly cellular component assembly plasma membrane bounded cell projection organization cell projection organization cellular process plasma membrane bounded cell projection assembly cellular component organization or biogenesis cell projection assembly transport monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport establishment of localization chloride transport transmembrane transport localization chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport inorganic anion transport import into cell regulation of localization regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization positive regulation of biological process positive regulation of membrane invagination vesicle-mediated transport positive regulation of endocytosis regulation of phagocytosis, engulfment membrane invagination phagocytosis plasma membrane invagination positive regulation of cellular process regulation of endocytosis membrane organization regulation of biological process regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport phagocytosis, engulfment positive regulation of phagocytosis positive regulation of transport positive regulation of phagocytosis, engulfment regulation of membrane invagination endocytosis regulation of monoatomic ion transport regulation of monoatomic ion transmembrane transport regulation of transmembrane transport positive regulation of monoatomic ion transport positive regulation of transmembrane transport positive regulation of monoatomic ion transmembrane transport positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death regulation of developmental process regulation of biomineral tissue development regulation of bone mineralization positive regulation of ossification positive regulation of developmental process multicellular organism development positive regulation of biomineral tissue development ossification anatomical structure development biomineral tissue development regulation of multicellular organismal process developmental process regulation of multicellular organismal development bone mineralization animal organ development tissue development positive regulation of bone mineralization positive regulation of multicellular organismal process regulation of ossification regulation of postsynaptic membrane potential regulation of membrane potential calcium activated phospholipid scrambling phospholipid translocation organic substance transport lipid localization phospholipid transport lipid transport lipid translocation regulation of membrane lipid distribution plasma membrane phospholipid scrambling plasma membrane organization macromolecule localization endomembrane system organization organophosphate ester transport bone maturation bone mineralization involved in bone maturation developmental maturation skeletal system development anatomical structure maturation ossification involved in bone maturation animal organ maturation bone development system development regulation of cellular component size homeostatic process cell volume homeostasis negative regulation of cell volume cellular homeostasis regulation of cell size regulation of anatomical structure size calcium activated phosphatidylserine scrambling cellular localization establishment of localization in cell calcium activated galactosylceramide scrambling calcium ion transport metal ion transport inorganic cation transmembrane transport monoatomic cation transmembrane transport monoatomic cation transport calcium ion transmembrane transport cell chemotaxis cellular response to stimulus chemotaxis dendritic cell chemotaxis response to external stimulus leukocyte migration dendritic cell migration cellular response to chemical stimulus taxis immune system process response to chemical mononuclear cell migration cell migration cell motility leukocyte chemotaxis locomotion positive regulation of monocyte chemotaxis positive regulation of locomotion regulation of cell motility regulation of response to external stimulus positive regulation of chemotaxis positive regulation of cell migration regulation of monocyte chemotaxis positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of cell motility regulation of cell migration myeloid leukocyte migration positive regulation of mononuclear cell migration regulation of immune system process regulation of mononuclear cell migration positive regulation of immune system process regulation of leukocyte chemotaxis regulation of leukocyte migration positive regulation of leukocyte migration positive regulation of leukocyte chemotaxis regulation of chemotaxis monocyte chemotaxis regulation of response to stimulus regulation of locomotion calcium activated phosphatidylcholine scrambling positive regulation of cation transmembrane transport regulation of potassium ion transport potassium ion transmembrane transport export across plasma membrane potassium ion export across plasma membrane positive regulation of potassium ion export across plasma membrane regulation of metal ion transport export from cell regulation of potassium ion transmembrane transport positive regulation of potassium ion transport regulation of potassium ion export across plasma membrane positive regulation of potassium ion transmembrane transport potassium ion transport regulation of monoatomic cation transmembrane transport purinergic nucleotide receptor signaling pathway cell surface receptor signaling pathway signaling cell communication signal transduction	protein-containing complex transmembrane transporter complex membrane chloride channel complex membrane protein complex cellular anatomical entity transporter complex monoatomic ion channel complex cell periphery plasma membrane synapse cell junction plasma membrane region synaptic membrane protein-containing complex transmembrane transporter complex membrane chloride channel complex membrane protein complex cellular anatomical entity transporter complex monoatomic ion channel complex cell periphery plasma membrane synapse cell junction plasma membrane region synaptic membrane cholinergic synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR032394	Anoctamin, dimerisation domain	Domain
A, B	IPR007632	Anoctamin	Family
A, B	IPR049452	Anoctamin, transmembrane domain	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	Calcium-activated chloride channel	Anoctamin (TMEM16) family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	TMEM16 Family Proteins	TMEM16F scramblase & ion channel in lipid nanodiscs, Ca⁺²-bound state

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.