Annotations: 6QBH

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00026	e6qbhA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF00026	ECOD (1.6)
B	PF00026	e6qbhB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF00026	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (utative)
B	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00026	Eukaryotic aspartyl protease (Asp)	Eukaryotic aspartyl protease	-	Family
B	PF00026	Eukaryotic aspartyl protease (Asp)	Eukaryotic aspartyl protease	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Cathepsin D	peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity cysteine-type peptidase activity cysteine-type endopeptidase activity endopeptidase activity aspartic-type peptidase activity aspartic-type endopeptidase activity	protein localization regulation of localization establishment of protein localization cellular localization regulation of biological process regulation of cellular process regulation of protein localization regulation of establishment of protein localization biological regulation establishment of localization localization regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization regulation of localization establishment of protein localization cellular localization regulation of biological process regulation of cellular process regulation of protein localization regulation of establishment of protein localization biological regulation establishment of localization localization regulation of cellular localization cellular macromolecule localization macromolecule localization cellular process autophagosome assembly catabolic process organelle assembly vacuole organization macroautophagy cellular metabolic process autophagy autophagosome organization cellular component biogenesis cellular component organization cellular catabolic process organelle organization cellular component assembly metabolic process cellular component organization or biogenesis process utilizing autophagic mechanism cellular response to stimulus cellular response to nitrogen compound positive regulation of cell communication response to organic substance positive regulation of signal transduction response to stimulus regulation of signal transduction insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication response to hormone receptor metabolic process signal transduction cellular response to hormone stimulus positive regulation of cellular response to insulin stimulus response to organonitrogen compound regulation of insulin receptor signaling pathway response to nitrogen compound cellular response to oxygen-containing compound receptor recycling cellular response to organonitrogen compound regulation of response to stimulus response to chemical response to insulin macromolecule metabolic process signaling response to peptide hormone positive regulation of biological process regulation of cellular response to insulin stimulus positive regulation of response to stimulus cellular response to endogenous stimulus organic substance metabolic process cellular response to organic substance enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of signaling cell surface receptor signaling pathway response to endogenous stimulus positive regulation of insulin receptor signaling pathway response to oxygen-containing compound cellular response to peptide hormone stimulus cellular response to chemical stimulus regulation of cell communication insulin receptor recycling cellular response to insulin stimulus positive regulation of signaling positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune system process antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of peptide antigen antigen processing and presentation of exogenous antigen regulation of catalytic activity positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of primary metabolic process positive regulation of molecular function positive regulation of metabolic process regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of proteolysis proteolysis regulation of endopeptidase activity positive regulation of macromolecule metabolic process protein metabolic process regulation of cysteine-type endopeptidase activity organonitrogen compound metabolic process regulation of protein metabolic process regulation of peptidase activity positive regulation of catalytic activity primary metabolic process regulation of macromolecule metabolic process regulation of molecular function positive regulation of hydrolase activity positive regulation of cysteine-type endopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis regulation of metabolic process organonitrogen compound catabolic process lipoprotein metabolic process protein catabolic process macromolecule catabolic process lipoprotein catabolic process organic substance catabolic process insulin catabolic process insulin metabolic process	membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle lytic vacuole membrane-enclosed lumen membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle lytic vacuole membrane-enclosed lumen vacuolar lumen vacuole lysosomal lumen intracellular organelle lumen organelle lumen lysosome extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix membrane microdomain membrane raft membrane ficolin-1-rich granule endomembrane system ficolin-1-rich granule lumen secretory granule secretory vesicle tertiary granule lumen tertiary granule vacuolar membrane lytic vacuole membrane bounding membrane of organelle lysosomal membrane organelle membrane endosome membrane endosome cytoplasmic vesicle membrane vesicle membrane vesicle lumen cytoplasmic vesicle lumen secretory granule lumen specific granule lumen specific granule endosome lumen
B	Cathepsin D	peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity cysteine-type peptidase activity cysteine-type endopeptidase activity endopeptidase activity aspartic-type peptidase activity aspartic-type endopeptidase activity	protein localization regulation of localization establishment of protein localization cellular localization regulation of biological process regulation of cellular process regulation of protein localization regulation of establishment of protein localization biological regulation establishment of localization localization regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization regulation of localization establishment of protein localization cellular localization regulation of biological process regulation of cellular process regulation of protein localization regulation of establishment of protein localization biological regulation establishment of localization localization regulation of cellular localization cellular macromolecule localization macromolecule localization cellular process autophagosome assembly catabolic process organelle assembly vacuole organization macroautophagy cellular metabolic process autophagy autophagosome organization cellular component biogenesis cellular component organization cellular catabolic process organelle organization cellular component assembly metabolic process cellular component organization or biogenesis process utilizing autophagic mechanism cellular response to stimulus cellular response to nitrogen compound positive regulation of cell communication response to organic substance positive regulation of signal transduction response to stimulus regulation of signal transduction insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication response to hormone receptor metabolic process signal transduction cellular response to hormone stimulus positive regulation of cellular response to insulin stimulus response to organonitrogen compound regulation of insulin receptor signaling pathway response to nitrogen compound cellular response to oxygen-containing compound receptor recycling cellular response to organonitrogen compound regulation of response to stimulus response to chemical response to insulin macromolecule metabolic process signaling response to peptide hormone positive regulation of biological process regulation of cellular response to insulin stimulus positive regulation of response to stimulus cellular response to endogenous stimulus organic substance metabolic process cellular response to organic substance enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of signaling cell surface receptor signaling pathway response to endogenous stimulus positive regulation of insulin receptor signaling pathway response to oxygen-containing compound cellular response to peptide hormone stimulus cellular response to chemical stimulus regulation of cell communication insulin receptor recycling cellular response to insulin stimulus positive regulation of signaling positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune system process antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of peptide antigen antigen processing and presentation of exogenous antigen regulation of catalytic activity positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of primary metabolic process positive regulation of molecular function positive regulation of metabolic process regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of proteolysis proteolysis regulation of endopeptidase activity positive regulation of macromolecule metabolic process protein metabolic process regulation of cysteine-type endopeptidase activity organonitrogen compound metabolic process regulation of protein metabolic process regulation of peptidase activity positive regulation of catalytic activity primary metabolic process regulation of macromolecule metabolic process regulation of molecular function positive regulation of hydrolase activity positive regulation of cysteine-type endopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis regulation of metabolic process organonitrogen compound catabolic process lipoprotein metabolic process protein catabolic process macromolecule catabolic process lipoprotein catabolic process organic substance catabolic process insulin catabolic process insulin metabolic process	membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle lytic vacuole membrane-enclosed lumen membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle lytic vacuole membrane-enclosed lumen vacuolar lumen vacuole lysosomal lumen intracellular organelle lumen organelle lumen lysosome extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix membrane microdomain membrane raft membrane ficolin-1-rich granule endomembrane system ficolin-1-rich granule lumen secretory granule secretory vesicle tertiary granule lumen tertiary granule vacuolar membrane lytic vacuole membrane bounding membrane of organelle lysosomal membrane organelle membrane endosome membrane endosome cytoplasmic vesicle membrane vesicle membrane vesicle lumen cytoplasmic vesicle lumen secretory granule lumen specific granule lumen specific granule endosome lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001461	Aspartic peptidase A1 family	Family
A	IPR033121	Peptidase family A1 domain	Domain
A	IPR033144	Cathepsin D	Family
A	IPR021109	Aspartic peptidase domain superfamily	Homologous Superfamily
A	IPR001969	Aspartic peptidase, active site	Active Site
A	IPR012848	Aspartic peptidase, N-terminal	Domain
B	IPR001461	Aspartic peptidase A1 family	Family
B	IPR033121	Peptidase family A1 domain	Domain
B	IPR033144	Cathepsin D	Family
B	IPR021109	Aspartic peptidase domain superfamily	Homologous Superfamily
B	IPR001969	Aspartic peptidase, active site	Active Site
B	IPR012848	Aspartic peptidase, N-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P07339	neuronal ceroid lipofuscinosis 10 Alzheimer disease renal cell carcinoma rheumatoid arthritis papillary renal cell carcinoma sarcomatoid renal cell carcinoma Weight Gain neuronal ceroid lipofuscinosis prostate cancer collecting duct carcinoma amyotrophic lateral sclerosis type 1 chromophobe renal cell carcinoma kidney disease lung carcinoma myocardial infarction neuronal ceroid lipofuscinosis 10 Alzheimer disease renal cell carcinoma rheumatoid arthritis papillary renal cell carcinoma sarcomatoid renal cell carcinoma Weight Gain neuronal ceroid lipofuscinosis prostate cancer collecting duct carcinoma amyotrophic lateral sclerosis type 1 chromophobe renal cell carcinoma kidney disease lung carcinoma myocardial infarction neurodegenerative disease osteoarthritis susceptibility 1 renal carcinoma clear cell renal carcinoma diabetes mellitus hepatocellular carcinoma intellectual disability lysosomal storage disease myopathy breast carcinoma subependymal giant cell astrocytoma inborn errors of metabolism invasive ductal breast carcinoma lung cancer MALT lymphoma osteoarthritis ovarian cancer ulcerative colitis glioblastoma inflammatory bowel disease
B	Pharos: P07339	neuronal ceroid lipofuscinosis 10 Alzheimer disease renal cell carcinoma rheumatoid arthritis papillary renal cell carcinoma sarcomatoid renal cell carcinoma Weight Gain neuronal ceroid lipofuscinosis prostate cancer collecting duct carcinoma amyotrophic lateral sclerosis type 1 chromophobe renal cell carcinoma kidney disease lung carcinoma myocardial infarction neuronal ceroid lipofuscinosis 10 Alzheimer disease renal cell carcinoma rheumatoid arthritis papillary renal cell carcinoma sarcomatoid renal cell carcinoma Weight Gain neuronal ceroid lipofuscinosis prostate cancer collecting duct carcinoma amyotrophic lateral sclerosis type 1 chromophobe renal cell carcinoma kidney disease lung carcinoma myocardial infarction neurodegenerative disease osteoarthritis susceptibility 1 renal carcinoma clear cell renal carcinoma diabetes mellitus hepatocellular carcinoma intellectual disability lysosomal storage disease myopathy breast carcinoma subependymal giant cell astrocytoma inborn errors of metabolism invasive ductal breast carcinoma lung cancer MALT lymphoma osteoarthritis ovarian cancer ulcerative colitis glioblastoma inflammatory bowel disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.