Annotations: 6Q6G

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth L]	SCOP2B Superfamily	galactose-binding domain-like	8037020	3000087	SCOP2B (2022-06-29)
G [auth I]	SCOP2B Superfamily	WD40 repeat-like	8106386	3001694	SCOP2B (2022-06-29)
G [auth I]	SCOP2B Superfamily	WD40 repeat-like	8106386	3001694	SCOP2B (2022-06-29)
A [auth R]	SCOP2B Superfamily	WD40 repeat-like	8106388	3001694	SCOP2B (2022-06-29)
J [auth C]	SCOP2B Superfamily	RING/U-box like	8082719	3000160	SCOP2B (2022-06-29)
K [auth G]	SCOP2B Superfamily	CDC26-like	8053843	3002235	SCOP2B (2022-06-29)
L [auth W]	SCOP2B Superfamily	CDC26-like	8053843	3002235	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Anaphase-promoting complex subunit 13	8093172	3002688	SCOP2B (2022-06-29)
N [auth H]	SCOP2B Superfamily	Anaphase-promoting complex subunit 16-like	8053719	3002218	SCOP2B (2022-06-29)
S [auth U]	SCOP2B Superfamily	TPR-like	8057064	3001345	SCOP2B (2022-06-29)
T [auth V]	SCOP2B Superfamily	TPR-like	8057064	3001345	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth L]	PF03256	e6q6gL1	A: beta sandwiches	X: jelly-roll	H: Galactose-binding domain-like (From Topology)	T: Galactose-binding domain-like	F: PF03256	ECOD (1.6)
G [auth I]	PF12894	e6q6gI1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF12894	ECOD (1.6)
G [auth I]	PF12896	e6q6gI2	A: alpha bundles	X: Four-helical up-and-down bundle	H: Helical bundle domain in anaphase-promoting complex subunit 4 (From Topology)	T: Helical bundle domain in anaphase-promoting complex subunit 4	F: PF12896	ECOD (1.6)
H [auth O]	PF21371	e6q6gO2	A: alpha arrays	X: SHQ1 C-terminal domain-like	H: Anaphase-promoting complex subunit 5 N-terminal domain (From Topology)	T: Anaphase-promoting complex subunit 5 N-terminal domain	F: PF21371	ECOD (1.6)
H [auth O]	PF12862	e6q6gO1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF12862	ECOD (1.6)
J [auth C]	PF12861	e6q6gC1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: PF12861	ECOD (1.6)
P	PF00515,PF12895	e6q6gP1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF00515,PF12895	ECOD (1.6)
O [auth J]	PF00515,PF12895	e6q6gJ1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF00515,PF12895	ECOD (1.6)
R [auth Y]	F_UNCLASSIFIED	e6q6gY1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: F_UNCLASSIFIED	ECOD (1.6)
U [auth Z]	F_UNCLASSIFIED	e6q6gZ1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: F_UNCLASSIFIED	ECOD (1.6)
S [auth U]	F_UNCLASSIFIED	e6q6gU2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: F_UNCLASSIFIED	ECOD (1.6)
S [auth U]	PF00515	e6q6gU1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF00515	ECOD (1.6)
S [auth U]	PF04049	e6q6gU3	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF04049	ECOD (1.6)
T [auth V]	PF04049	e6q6gV1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF04049	ECOD (1.6)
E [auth A]	PF21282	e6q6gA1	A: beta sandwiches	X: 26S proteasome subunit Rpn2 C-terminal domain (From Topology)	H: 26S proteasome subunit Rpn2 C-terminal domain (From Topology)	T: 26S proteasome subunit Rpn2 C-terminal domain	F: PF21282	ECOD (1.6)
E [auth A]	PF12859	e6q6gA4	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF12859	ECOD (1.6)
E [auth A]	PF01851	e6q6gA5	A: alpha superhelices	X: Repetitive alpha hairpins	H: Proteasome/cyclosome (PC) repeat (From Topology)	T: Proteasome/cyclosome (PC) repeat	F: PF01851	ECOD (1.6)
E [auth A]	PF20518	e6q6gA3	A: alpha superhelices	X: Repetitive alpha hairpins	H: Anaphase-promoting complex subunit 1 first helical domain (From Topology)	T: Anaphase-promoting complex subunit 1 first helical domain	F: PF20518	ECOD (1.6)
E [auth A]	PF18122	e6q6gA2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Anaphase-promoting complex subunit 1 second helical domain (From Topology)	T: Anaphase-promoting complex subunit 1 second helical domain	F: PF18122	ECOD (1.6)
F [auth N]	F_UNCLASSIFIED	e6q6gN4	A: alpha arrays	X: HTH	H: HTH	T: winged	F: F_UNCLASSIFIED	ECOD (1.6)
F [auth N]	F_UNCLASSIFIED	e6q6gN3	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: F_UNCLASSIFIED	ECOD (1.6)
F [auth N]	PF00888	e6q6gN2	A: a+b duplicates or obligate multimers	X: a+b domain in cullin-like proteins (From Topology)	H: a+b domain in cullin-like proteins (From Topology)	T: a+b domain in cullin-like proteins	F: PF00888	ECOD (1.6)
Q	PF12895	e6q6gQ1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF12895	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth L]	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (utative)
J [auth C]	3.30.40.10	Alpha Beta	2-Layer Sandwich	Herpes Virus-1	Zinc/RING finger domain, C3HC4 (zinc finger)	CATH (utative)
S [auth U]	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (utative)
T [auth V]	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth L]	PF03256	Anaphase-promoting complex, subunit 10 (APC10) (ANAPC10)	Anaphase-promoting complex, subunit 10 (APC10)	-	Family
G [auth I]	PF12894	Anaphase-promoting complex subunit 4 WD40 domain (ANAPC4_WD40)	Anaphase-promoting complex subunit 4 WD40 domain	-	Repeat
H [auth O]	PF12862	Anaphase-promoting complex subunit 5 (ANAPC5)	Anaphase-promoting complex subunit 5	-	Repeat
H [auth O]	PF21371	Anaphase-promoting complex subunit 5, N-terminal domain (Apc5_N)	Anaphase-promoting complex subunit 5, N-terminal domain	This domain is found at the N-terminal end of Anaphase-promoting complex subunit 5 from humans (Apc5), a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitos ...	This domain is found at the N-terminal end of Anaphase-promoting complex subunit 5 from humans (Apc5), a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. This domain has an alpha-helical fold [1-4]. It is normally found in association with Pfam:PF12862.	Domain
A [auth R]	PF12894	Anaphase-promoting complex subunit 4 WD40 domain (ANAPC4_WD40)	Anaphase-promoting complex subunit 4 WD40 domain	-	Repeat
A [auth R]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
J [auth C]	PF12861	Anaphase-promoting complex subunit 11 RING-H2 finger (zf-ANAPC11)	Anaphase-promoting complex subunit 11 RING-H2 finger	Apc11 is one of the subunits of the anaphase-promoting complex or cyclosome [1]. The APC subunits are cullin family proteins with ubiquitin ligase activity [2]. Polyubiquitination marks proteins for degradation by the 26S proteasome and is carried ou ...	Apc11 is one of the subunits of the anaphase-promoting complex or cyclosome [1]. The APC subunits are cullin family proteins with ubiquitin ligase activity [2]. Polyubiquitination marks proteins for degradation by the 26S proteasome and is carried out by a cascade of enzymes that includes ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s). Apc11 acts as an E3 enzyme and is responsible for recruiting E2s to the APC and for mediating the subsequent transfer of ubiquitin to APC substrates in vivo. In Saccharomyces cerevisiae this RING-H2 finger protein defines the minimal ubiquitin ligase activity of the APC, and the integrity of the RING-H2 finger is essential for budding yeast cell viability [3].	Domain
K [auth G], L [auth W]	PF10471	Anaphase-promoting complex APC subunit CDC26 (ANAPC_CDC26)	Anaphase-promoting complex APC subunit CDC26	-	Family
M	PF05839	Apc13p protein (Apc13p)	Apc13p protein	-	Family
N [auth H]	PF17256	Anaphase-promoting complex, subunit 16 (ANAPC16)	Anaphase-promoting complex, subunit 16	-	Family
O [auth J], P	PF12895	Anaphase-promoting complex, cyclosome, subunit 3 (ANAPC3)	Anaphase-promoting complex, cyclosome, subunit 3	-	Repeat
O [auth J], P	PF00515	Tetratricopeptide repeat (TPR_1)	Tetratricopeptide repeat	-	Repeat
R [auth Y], U [auth Z]	PF13181	Tetratricopeptide repeat (TPR_8)	Tetratricopeptide repeat	-	Repeat
S [auth U], T [auth V]	PF04049	Anaphase promoting complex subunit 8 / Cdc23 (ANAPC8)	Anaphase promoting complex subunit 8 / Cdc23	-	Repeat
D	PF15243	Anaphase-promoting complex subunit 15 (ANAPC15)	Anaphase-promoting complex subunit 15	-	Family
E [auth A]	PF20518	Anaphase-promoting complex subunit 1 middle domain (Apc1_MidN)	Anaphase-promoting complex subunit 1 middle domain	-	Repeat
E [auth A]	PF18122	Anaphase-promoting complex sub unit 1 C-terminal domain (APC1_C)	Anaphase-promoting complex sub unit 1 C-terminal domain	This is the C-terminal domain of chain A, also known as sub-unit 1, found in anaphase-promoting complex (APC/C) present in Homo sapiens. APC/C is an ubiquitin ligase that controls chromosome segregation and mitotic exit [1].	Domain
E [auth A]	PF21282	APC1 beta sandwich domain (APC1_3rd)	APC1 beta sandwich domain	This domain is found close to the C-terminus of the APC1 protein which is a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the ce ...	This domain is found close to the C-terminus of the APC1 protein which is a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.	Domain
F [auth N]	PF00888	Cullin family (Cullin)	Cullin family	-	Repeat
I [auth K], Q	PF13424	Tetratricopeptide repeat (TPR_12)	Tetratricopeptide repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C [auth L]	Anaphase-promoting complex subunit 10	-	cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle cell division	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex
G [auth I]	Anaphase-promoting complex subunit 4	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity protein phosphatase binding phosphatase binding protein binding binding enzyme binding	cellular process cell cycle regulation of chromosome segregation regulation of cell cycle phase transition regulation of cellular process regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle cellular component organization regulation of mitotic cell cycle cellular component organization or biogenesis regulation of cell cycle cellular process cell cycle regulation of chromosome segregation regulation of cell cycle phase transition regulation of cellular process regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle cellular component organization regulation of mitotic cell cycle cellular component organization or biogenesis regulation of cell cycle chromosome segregation cell cycle process regulation of biological process regulation of cell cycle process biological regulation chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex organelle intracellular protein-containing complex cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear periphery nuclear lumen nucleoplasm
H [auth O]	Anaphase-promoting complex subunit 5	protein phosphatase binding phosphatase binding protein binding binding enzyme binding	cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process positive regulation of organelle organization regulation of cell cycle phase transition regulation of mitotic nuclear division positive regulation of mitotic nuclear division positive regulation of mitotic metaphase/anaphase transition positive regulation of mitotic cell cycle phase transition mitotic sister chromatid separation chromosome segregation regulation of cell cycle process positive regulation of nuclear division sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of chromosome separation regulation of chromosome segregation regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization regulation of mitotic sister chromatid separation positive regulation of cellular component organization positive regulation of biological process cell cycle phase transition regulation of mitotic metaphase/anaphase transition cellular component organization positive regulation of metaphase/anaphase transition of cell cycle mitotic sister chromatid segregation positive regulation of cell cycle process positive regulation of mitotic cell cycle cellular component organization or biogenesis positive regulation of cellular process cell cycle process mitotic nuclear division organelle fission chromosome organization positive regulation of cell cycle organelle organization nuclear division chromosome separation regulation of sister chromatid segregation positive regulation of cell cycle phase transition positive regulation of mitotic sister chromatid separation regulation of nuclear division nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle positive regulation of chromosome separation metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex organelle intracellular protein-containing complex cytoplasm cytosol cytoskeleton spindle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
A [auth R]	Cell division cycle protein 20 homolog	enzyme regulator activity ubiquitin ligase activator activity enzyme activator activity ubiquitin-protein transferase regulator activity molecular function activator activity molecular function regulator activity ubiquitin-protein transferase activator activity ubiquitin-like ligase-substrate adaptor activity enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity protein-containing complex binding anaphase-promoting complex binding binding	positive regulation of proteasomal protein catabolic process catabolic process regulation of anaphase-promoting complex-dependent catabolic process proteolysis involved in protein catabolic process positive regulation of protein metabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis positive regulation of ubiquitin-dependent protein catabolic process positive regulation of proteasomal protein catabolic process catabolic process regulation of anaphase-promoting complex-dependent catabolic process proteolysis involved in protein catabolic process positive regulation of protein metabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis positive regulation of ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process biological regulation primary metabolic process proteasomal protein catabolic process protein catabolic process regulation of macromolecule metabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process regulation of proteasomal protein catabolic process positive regulation of proteolysis positive regulation of anaphase-promoting complex-dependent catabolic process anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process macromolecule metabolic process organic substance catabolic process regulation of metabolic process regulation of protein catabolic process developmental process cellular developmental process cell differentiation cellular process multicellular organismal process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization regulation of developmental process cellular component organization positive regulation of developmental process multicellular organism development anatomical structure development regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of biological quality positive regulation of cellular process system development nervous system development developmental maturation synapse maturation regulation of synapse organization regulation of synapse maturation cell junction organization positive regulation of synapse maturation regulation of mitotic cell cycle cell cycle regulation of cell cycle mitotic cell cycle positive regulation of organelle organization regulation of cell cycle phase transition regulation of mitotic nuclear division positive regulation of mitotic nuclear division positive regulation of mitotic metaphase/anaphase transition positive regulation of mitotic cell cycle phase transition mitotic sister chromatid separation chromosome segregation regulation of cell cycle process positive regulation of nuclear division sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of chromosome separation regulation of chromosome segregation regulation of metaphase/anaphase transition of cell cycle regulation of mitotic sister chromatid separation cell cycle phase transition regulation of mitotic metaphase/anaphase transition positive regulation of metaphase/anaphase transition of cell cycle mitotic sister chromatid segregation positive regulation of cell cycle process positive regulation of mitotic cell cycle cell cycle process mitotic nuclear division organelle fission chromosome organization positive regulation of cell cycle organelle organization nuclear division chromosome separation regulation of sister chromatid segregation positive regulation of cell cycle phase transition positive regulation of mitotic sister chromatid separation regulation of nuclear division nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle positive regulation of chromosome separation metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition cell division cellular response to stimulus response to stimulus negative regulation of biological process spindle checkpoint signaling negative regulation of cell cycle intracellular signal transduction negative regulation of mitotic cell cycle cell communication negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition mitotic spindle checkpoint signaling signal transduction negative regulation of sister chromatid segregation mitotic spindle assembly checkpoint signaling negative regulation of cellular component organization regulation of mitotic sister chromatid segregation negative regulation of mitotic nuclear division signaling spindle assembly checkpoint signaling negative regulation of cellular process negative regulation of mitotic metaphase/anaphase transition negative regulation of chromosome separation negative regulation of mitotic cell cycle phase transition negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling negative regulation of chromosome segregation negative regulation of organelle organization negative regulation of nuclear division negative regulation of mitotic sister chromatid separation negative regulation of metaphase/anaphase transition of cell cycle regulation of synaptic plasticity trans-synaptic signaling regulation of signaling modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission positive regulation of synaptic plasticity synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle regulation of protein modification process regulation of catalytic activity regulation of protein ubiquitination regulation of transferase activity positive regulation of post-translational protein modification regulation of ubiquitin protein ligase activity positive regulation of molecular function positive regulation of ubiquitin protein ligase activity positive regulation of protein modification process regulation of ubiquitin-protein transferase activity regulation of protein modification by small protein conjugation or removal positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination positive regulation of transferase activity regulation of post-translational protein modification positive regulation of catalytic activity positive regulation of ubiquitin-protein transferase activity regulation of molecular function meiotic cell cycle process metaphase/anaphase transition of meiotic cell cycle meiotic cell cycle phase transition meiosis I cell cycle process metaphase/anaphase transition of meiosis I mitotic sister chromatid cohesion sister chromatid cohesion non-membrane-bounded organelle assembly microtubule cytoskeleton organization cellular component biogenesis cellular component assembly microtubule cytoskeleton organization involved in mitosis spindle organization organelle assembly spindle assembly mitotic spindle organization mitotic spindle assembly microtubule-based process cytoskeleton organization meiotic nuclear division regulation of meiotic nuclear division	intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle centrosome microtubule organizing center cytoplasm cytosol intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle centrosome microtubule organizing center cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex mitotic checkpoint complex
J [auth C]	Anaphase-promoting complex subunit 11	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-ubiquitin ligase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity protein binding binding cullin family protein binding cation binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-ubiquitin ligase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity protein binding binding cullin family protein binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	cellular process cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis cellular process cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process anaphase-promoting complex-dependent catabolic process positive regulation of organelle organization regulation of cell cycle phase transition regulation of mitotic nuclear division positive regulation of mitotic nuclear division positive regulation of mitotic metaphase/anaphase transition positive regulation of mitotic cell cycle phase transition mitotic sister chromatid separation chromosome segregation regulation of cell cycle process positive regulation of nuclear division sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of chromosome separation regulation of chromosome segregation regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization regulation of mitotic sister chromatid separation positive regulation of cellular component organization positive regulation of biological process cell cycle phase transition regulation of mitotic metaphase/anaphase transition cellular component organization positive regulation of metaphase/anaphase transition of cell cycle mitotic sister chromatid segregation positive regulation of cell cycle process positive regulation of mitotic cell cycle cellular component organization or biogenesis positive regulation of cellular process cell cycle process mitotic nuclear division organelle fission chromosome organization positive regulation of cell cycle organelle organization nuclear division chromosome separation regulation of sister chromatid segregation positive regulation of cell cycle phase transition positive regulation of mitotic sister chromatid separation regulation of nuclear division nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle positive regulation of chromosome separation metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex cytoplasm cytosol nucleoplasm
K [auth G], L [auth W]	Anaphase-promoting complex subunit CDC26	-	cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle cell division	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex
M	Anaphase-promoting complex subunit 13	-	cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle cell division	membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex organelle intracellular protein-containing complex
N [auth H]	Anaphase-promoting complex subunit 16	-	cellular process cell cycle organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cellular process cell cycle organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process organic substance catabolic process regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle cell division	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol chromosome chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome intracellular anatomical structure cytoplasm cellular anatomical entity cytosol chromosome chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex
O [auth J], P	Cell division cycle protein 27 homolog	protein phosphatase binding phosphatase binding protein binding binding enzyme binding	regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation cellular process cell cycle regulation of cell cycle mitotic cell cycle regulation of chromosome segregation regulation of cellular component organization cell cycle phase transition cellular component organization cellular component organization or biogenesis chromosome segregation regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation cellular process cell cycle regulation of cell cycle mitotic cell cycle regulation of chromosome segregation regulation of cellular component organization cell cycle phase transition cellular component organization cellular component organization or biogenesis chromosome segregation cell cycle process regulation of cell cycle process chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle membrane-bounded organelle protein-containing complex ubiquitin ligase complex catalytic complex intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle membrane-bounded organelle protein-containing complex ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex cytoplasm cytosol spindle mitotic spindle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
R [auth Y], U [auth Z]	Anaphase-promoting complex subunit 7	enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity protein phosphatase binding phosphatase binding protein binding binding enzyme binding	cellular process cell cycle developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development regulation of mitotic cell cycle regulation of biological process cellular process cell cycle developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process positive regulation of organelle organization regulation of cell cycle phase transition regulation of mitotic nuclear division positive regulation of mitotic nuclear division positive regulation of mitotic metaphase/anaphase transition positive regulation of mitotic cell cycle phase transition mitotic sister chromatid separation chromosome segregation regulation of cell cycle process positive regulation of nuclear division sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of chromosome separation regulation of chromosome segregation regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization regulation of mitotic sister chromatid separation positive regulation of cellular component organization positive regulation of biological process cell cycle phase transition regulation of mitotic metaphase/anaphase transition cellular component organization positive regulation of metaphase/anaphase transition of cell cycle mitotic sister chromatid segregation positive regulation of cell cycle process positive regulation of mitotic cell cycle cellular component organization or biogenesis positive regulation of cellular process cell cycle process mitotic nuclear division organelle fission chromosome organization positive regulation of cell cycle organelle organization nuclear division chromosome separation regulation of sister chromatid segregation positive regulation of cell cycle phase transition positive regulation of mitotic sister chromatid separation regulation of nuclear division nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle positive regulation of chromosome separation metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	protein-containing complex intracellular anatomical structure protein-DNA complex chromatin chromosome cellular anatomical entity heterochromatin intracellular organelle organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle membrane-bounded organelle ubiquitin ligase complex catalytic complex protein-containing complex intracellular anatomical structure protein-DNA complex chromatin chromosome cellular anatomical entity heterochromatin intracellular organelle organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle membrane-bounded organelle ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex cytoplasm cytosol cytoskeleton spindle microtubule cytoskeleton membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
S [auth U], T [auth V]	Cell division cycle protein 23 homolog	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity	cellular process cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis cellular process cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process regulation of chromosome segregation regulation of cell cycle phase transition regulation of cellular process regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization cell cycle phase transition regulation of mitotic metaphase/anaphase transition cellular component organization regulation of mitotic cell cycle cellular component organization or biogenesis regulation of cell cycle chromosome segregation cell cycle process regulation of biological process regulation of cell cycle process biological regulation chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process anaphase-promoting complex-dependent catabolic process positive regulation of organelle organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division positive regulation of mitotic metaphase/anaphase transition positive regulation of mitotic cell cycle phase transition mitotic sister chromatid separation positive regulation of nuclear division regulation of chromosome separation regulation of mitotic sister chromatid separation positive regulation of cellular component organization positive regulation of biological process positive regulation of metaphase/anaphase transition of cell cycle mitotic sister chromatid segregation positive regulation of cell cycle process positive regulation of mitotic cell cycle positive regulation of cellular process mitotic nuclear division organelle fission positive regulation of cell cycle nuclear division chromosome separation positive regulation of cell cycle phase transition positive regulation of mitotic sister chromatid separation regulation of nuclear division positive regulation of chromosome separation protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal exit from mitosis regulation of exit from mitosis cell division establishment of organelle localization cellular localization mitotic metaphase chromosome alignment metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell establishment of localization establishment of chromosome localization regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex organelle intracellular protein-containing complex cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
B [auth S]	Cyclin-A2	protein binding binding protein domain specific binding kinase binding enzyme binding protein kinase binding enzyme regulator activity cyclin-dependent protein serine/threonine kinase regulator activity molecular function regulator activity protein kinase regulator activity kinase regulator activity	developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development cellular response to stimulus cellular response to nitrogen compound response to organic substance response to stimulus response to peptide hormone cellular response to endogenous stimulus response to hormone developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development cellular response to stimulus cellular response to nitrogen compound response to organic substance response to stimulus response to peptide hormone cellular response to endogenous stimulus response to hormone cellular response to organic substance cellular response to hormone stimulus cellular response to gonadotropin stimulus cellular response to luteinizing hormone stimulus response to endogenous stimulus response to organonitrogen compound response to luteinizing hormone cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound response to gonadotropin cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical cellular process cellular response to insulin-like growth factor stimulus cellular response to growth factor stimulus cellular response to platelet-derived growth factor stimulus response to growth factor response to platelet-derived growth factor cell division response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to stress response to hypoxia response to stress response to oxygen levels response to abiotic stimulus response to glucagon regulation of biological process biological regulation primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process fibroblast proliferation cell population proliferation regulation of cellular process positive regulation of cell population proliferation positive regulation of biological process regulation of fibroblast proliferation regulation of cell population proliferation positive regulation of fibroblast proliferation positive regulation of cellular process cellular biosynthetic process cellular metabolic process RNA metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process small GTPase-mediated signal transduction signaling Ras protein signal transduction intracellular signal transduction cell communication intracellular signaling cassette signal transduction organonitrogen compound metabolic process macromolecule modification protein metabolic process post-translational protein modification protein modification process cellular response to leptin stimulus response to leptin cellular response to organic cyclic compound response to alkaloid cellular response to cocaine cellular response to alkaloid response to organic cyclic compound response to cocaine mitotic cell cycle process cell cycle phase transition cell cycle G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle mitotic cell cycle phase transition cell cycle process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process response to lipid cellular response to lipid response to estradiol cellular response to estradiol stimulus regulation of DNA biosynthetic process positive regulation of DNA biosynthetic process positive regulation of DNA metabolic process DNA biosynthetic process animal organ regeneration regeneration cell cycle G2/M phase transition G2/M transition of mitotic cell cycle cellular response to inorganic substance response to inorganic substance cellular response to nitric oxide response to nitric oxide cellular response to reactive nitrogen species	protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex serine/threonine protein kinase complex cyclin-dependent protein kinase holoenzyme complex transferase complex intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex serine/threonine protein kinase complex cyclin-dependent protein kinase holoenzyme complex transferase complex intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen pronucleus male pronucleus female pronucleus cyclin A2-CDK1 complex cyclin A2-CDK2 complex
D	Anaphase-promoting complex subunit 15	-	cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle cell division cellular response to stimulus regulation of cell cycle phase transition response to stimulus negative regulation of biological process spindle checkpoint signaling negative regulation of cell cycle regulation of signal transduction regulation of mitotic nuclear division intracellular signal transduction negative regulation of mitotic cell cycle cell communication regulation of cell cycle checkpoint negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition mitotic spindle checkpoint signaling signal transduction mitotic sister chromatid separation chromosome segregation negative regulation of sister chromatid segregation mitotic spindle assembly checkpoint signaling negative regulation of cellular component organization regulation of cell cycle process regulation of spindle checkpoint sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition regulation of mitotic sister chromatid segregation mitotic cell cycle process regulation of response to stimulus regulation of chromosome separation negative regulation of mitotic nuclear division regulation of chromosome segregation regulation of cellular component organization regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle regulation of mitotic spindle checkpoint signaling regulation of mitotic cell cycle spindle assembly checkpoint spindle assembly checkpoint signaling cell cycle phase transition regulation of mitotic metaphase/anaphase transition cellular component organization regulation of intracellular signal transduction negative regulation of cellular process mitotic sister chromatid segregation negative regulation of mitotic metaphase/anaphase transition cellular component organization or biogenesis negative regulation of chromosome separation cell cycle process mitotic nuclear division regulation of signaling negative regulation of mitotic cell cycle phase transition organelle fission chromosome organization negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling organelle organization nuclear division negative regulation of chromosome segregation chromosome separation negative regulation of organelle organization negative regulation of nuclear division regulation of sister chromatid segregation negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle regulation of cell communication metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex
E [auth A]	Anaphase-promoting complex subunit 1,Anaphase-promoting complex subunit 1	molecular adaptor activity	regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation cellular process cell cycle regulation of cell cycle mitotic cell cycle regulation of chromosome segregation regulation of cellular component organization cell cycle phase transition cellular component organization cellular component organization or biogenesis chromosome segregation regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation cellular process cell cycle regulation of cell cycle mitotic cell cycle regulation of chromosome segregation regulation of cellular component organization cell cycle phase transition cellular component organization cellular component organization or biogenesis chromosome segregation cell cycle process regulation of cell cycle process chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex organelle intracellular protein-containing complex cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
F [auth N]	Anaphase-promoting complex subunit 2	ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding	developmental process cellular developmental process cell differentiation cellular process multicellular organismal process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization regulation of developmental process positive regulation of biological process cellular component organization positive regulation of developmental process multicellular organism development anatomical structure development developmental process cellular developmental process cell differentiation cellular process multicellular organismal process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization regulation of developmental process positive regulation of biological process cellular component organization positive regulation of developmental process multicellular organism development anatomical structure development regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of biological quality positive regulation of cellular process system development regulation of biological process biological regulation nervous system development developmental maturation synapse maturation regulation of synapse organization regulation of synapse maturation cell junction organization positive regulation of synapse maturation regulation of mitotic cell cycle cell cycle regulation of cell cycle mitotic cell cycle regulation of chromosome segregation cell cycle phase transition chromosome segregation cell cycle process regulation of cell cycle process chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cell division axon extension positive regulation of nervous system development regulation of growth axonogenesis regulation of cellular component size developmental growth cell projection organization regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development cell projection morphogenesis neuron differentiation neuron projection morphogenesis positive regulation of cell projection organization positive regulation of developmental growth regulation of cell projection organization positive regulation of cell development developmental growth involved in morphogenesis generation of neurons positive regulation of multicellular organismal process regulation of neuron projection development plasma membrane bounded cell projection morphogenesis cell development cell growth cell morphogenesis regulation of axon extension regulation of nervous system development neurogenesis regulation of extent of cell growth positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process positive regulation of axon extension positive regulation of axonogenesis regulation of anatomical structure morphogenesis regulation of cell size neuron projection extension regulation of multicellular organismal development regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth growth positive regulation of cell growth axon development regulation of cell growth cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis positive regulation of growth neuron development regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process organic substance biosynthetic process negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process regulation of synaptic plasticity trans-synaptic signaling regulation of signaling modulation of chemical synaptic transmission signaling cell-cell signaling chemical synaptic transmission cell communication positive regulation of synaptic plasticity synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication regulation of cell morphogenesis regulation of dendrite morphogenesis positive regulation of cell morphogenesis regulation of dendrite development dendrite development positive regulation of dendrite morphogenesis dendrite morphogenesis regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex anaphase-promoting complex intracellular organelle cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex organelle intracellular protein-containing complex cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
I [auth K], Q	Cell division cycle protein 16 homolog	-	cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process cellular process cell cycle regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation regulation of cell cycle mitotic cell cycle organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process positive regulation of organelle organization regulation of cell cycle phase transition regulation of mitotic nuclear division positive regulation of mitotic nuclear division positive regulation of mitotic metaphase/anaphase transition positive regulation of mitotic cell cycle phase transition mitotic sister chromatid separation chromosome segregation regulation of cell cycle process positive regulation of nuclear division sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of chromosome separation regulation of chromosome segregation regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization regulation of mitotic sister chromatid separation positive regulation of cellular component organization positive regulation of biological process cell cycle phase transition regulation of mitotic metaphase/anaphase transition cellular component organization positive regulation of metaphase/anaphase transition of cell cycle mitotic sister chromatid segregation positive regulation of cell cycle process positive regulation of mitotic cell cycle cellular component organization or biogenesis positive regulation of cellular process cell cycle process mitotic nuclear division organelle fission chromosome organization positive regulation of cell cycle organelle organization nuclear division chromosome separation regulation of sister chromatid segregation positive regulation of cell cycle phase transition positive regulation of mitotic sister chromatid separation regulation of nuclear division nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle positive regulation of chromosome separation metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition protein K11-linked ubiquitination protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cell division regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle	intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle membrane-bounded organelle protein-containing complex ubiquitin ligase complex catalytic complex intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle membrane-bounded organelle protein-containing complex ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex cytoplasm cytosol mitotic spindle spindle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth L]	IPR016901	Anaphase-promoting complex subunit APC10/Doc1	Family
C [auth L]	IPR004939	APC10/DOC domain	Domain
C [auth L]	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
G [auth I]	IPR017169	Anaphase-promoting complex subunit 4, metazoa	Family
G [auth I]	IPR024977	Anaphase-promoting complex subunit 4-like, WD40 domain	Domain
G [auth I]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
G [auth I]	IPR024789	Anaphase-promoting complex subunit 4	Family
G [auth I]	IPR024790	Anaphase-promoting complex subunit 4, long domain	Domain
G [auth I]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
H [auth O]	IPR026000	Anaphase-promoting complex subunit 5 domain	Domain
H [auth O]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
H [auth O]	IPR037679	Anaphase-promoting complex subunit 5	Family
H [auth O]	IPR019734	Tetratricopeptide repeat	Repeat
H [auth O]	IPR048968	Anaphase-promoting complex subunit 5, N-terminal domain	Domain
A [auth R]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A [auth R]	IPR024977	Anaphase-promoting complex subunit 4-like, WD40 domain	Domain
A [auth R]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A [auth R]	IPR001680	WD40 repeat	Repeat
A [auth R]	IPR033010	WD repeat Cdc20/Fizzy	Family
J [auth C]	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
J [auth C]	IPR024991	Anaphase-promoting complex subunit 11, RING-H2 finger	Domain
J [auth C]	IPR001841	Zinc finger, RING-type	Domain
K [auth G], L [auth W]	IPR018860	Anaphase-promoting complex, subunit CDC26	Family
M	IPR008401	Apc13	Family
N [auth H]	IPR029641	Anaphase-promoting complex subunit 16	Family
O [auth J], P	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
O [auth J], P	IPR001440	TPR_1	Unknown
O [auth J], P	IPR019734	Tetratricopeptide repeat	Repeat
R [auth Y], U [auth Z]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
R [auth Y], U [auth Z]	IPR019734	Tetratricopeptide repeat	Repeat
S [auth U], T [auth V]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
S [auth U], T [auth V]	IPR007192	Cdc23	Domain
S [auth U], T [auth V]	IPR019734	Tetratricopeptide repeat	Repeat
B [auth S]	IPR048258	Cyclins, cyclin-box	Conserved Site
B [auth S]	IPR004367	Cyclin, C-terminal domain	Domain
B [auth S]	IPR032447	Cyclin-A, N-terminal APC/C binding region	Domain
B [auth S]	IPR046965	Cyclin A/B-like	Family
B [auth S]	IPR006671	Cyclin, N-terminal	Domain
B [auth S]	IPR036915	Cyclin-like superfamily	Homologous Superfamily
B [auth S]	IPR039361	Cyclin	Family
B [auth S]	IPR013763	Cyclin-like domain	Domain
D	IPR026182	Anaphase-promoting complex subunit 15	Family
E [auth A]	IPR041221	Anaphase-promoting complex subunit 1, C-terminal	Domain
E [auth A]	IPR046794	Anaphase-promoting complex subunit 1, middle domain	Domain
E [auth A]	IPR024990	Anaphase-promoting complex subunit 1	Family
E [auth A]	IPR048971	Anaphase-promoting complex subunit 1, beta-sandwich domain	Domain
E [auth A]	IPR049255	Anaphase-promoting complex subunit 1, N-terminal domain	Domain
E [auth A]	IPR011989	Armadillo-like helical	Homologous Superfamily
F [auth N]	IPR014786	Anaphase-promoting complex subunit 2, C-terminal	Domain
F [auth N]	IPR016158	Cullin homology domain	Domain
F [auth N]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
F [auth N]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
F [auth N]	IPR036317	Cullin homology domain superfamily	Homologous Superfamily
F [auth N]	IPR044554	Anaphase-promoting complex subunit 2	Family
F [auth N]	IPR001373	Cullin, N-terminal	Domain
I [auth K], Q	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
I [auth K], Q	IPR019734	Tetratricopeptide repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth L]	Pharos: Q9UM13	atrial fibrillation large cell medulloblastoma psoriasis colorectal adenoma non-alcoholic fatty liver disease colorectal cancer ovarian cancer
G [auth I]	Pharos: Q9UJX5	colorectal cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia osteosarcoma ovarian cancer
H [auth O]	Pharos: Q9UJX4	non-small cell lung carcinoma ovarian cancer psoriasis adrenal cortex carcinoma bipolar disorder endogenous depression interstitial lung disease lung adenocarcinoma malignant ependymoma medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma Sjogren syndrome astrocytic tumor congestive heart failure non-small cell lung carcinoma ovarian cancer psoriasis adrenal cortex carcinoma bipolar disorder endogenous depression interstitial lung disease lung adenocarcinoma malignant ependymoma medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma Sjogren syndrome astrocytic tumor congestive heart failure Gaucher disease juvenile dermatomyositis lung cancer Malignant neoplasm of breast myopathy osteosarcoma Pick disease atypical teratoid rhabdoid tumor diabetes mellitus glioblastoma large cell medulloblastoma lung carcinoma MALT lymphoma
A [auth R]	Pharos: Q12834	malignant glioma medulloblastoma ovarian cancer primitive neuroectodermal tumor acute pancreatitis atypical teratoid rhabdoid tumor ductal breast carcinoma in situ glioblastoma IgA glomerulonephritis large cell medulloblastoma malignant colon neoplasm malignant mesothelioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma psoriasis malignant glioma medulloblastoma ovarian cancer primitive neuroectodermal tumor acute pancreatitis atypical teratoid rhabdoid tumor ductal breast carcinoma in situ glioblastoma IgA glomerulonephritis large cell medulloblastoma malignant colon neoplasm malignant mesothelioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma psoriasis adrenal cortex carcinoma breast cancer endometriosis hepatocellular carcinoma interstitial cystitis lung adenocarcinoma malignant ependymoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm atopic eczema breast carcinoma esophageal adenocarcinoma hypertensive disorder invasive ductal breast carcinoma lung cancer
J [auth C]	Pharos: Q9NYG5	attention deficit hyperactivity disorder, inattentive type
K [auth G], L [auth W]	Pharos: Q8NHZ8	diabetes mellitus
M	Pharos: Q9BS18	breast cancer plasma cell myeloma malignant mesothelioma ovarian cancer
N [auth H]	Pharos: Q96DE5	malignant ependymoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm non-small cell lung carcinoma pancreatic ductal adenocarcinoma Sjogren syndrome osteosarcoma pancreatic intraductal papillary-mucinous carcinoma
O [auth J], P	Pharos: P30260	prostate cancer atypical teratoid rhabdoid tumor large cell medulloblastoma medulloblastoma ulcerative colitis Crohn disease lung cancer osteosarcoma Prostatic Neoplasms glioblastoma ovarian cancer psoriasis
R [auth Y], U [auth Z]	Pharos: Q9UJX3	anorexia nervosa osteosarcoma autism spectrum disorder pancreatic intraductal papillary-mucinous neoplasm bipolar disorder Pick disease
S [auth U], T [auth V]	Pharos: Q9UJX2	adrenal cortex carcinoma dermatomyositis ovarian cancer Sjogren syndrome astrocytic tumor invasive ductal breast carcinoma pancreatic intraductal papillary-mucinous carcinoma atrial fibrillation medulloblastoma pancreatic intraductal papillary-mucinous neoplasm
B [auth S]	Pharos: P20248	intellectual disability psoriasis Liver Cirrhosis, Experimental malignant ependymoma medulloblastoma nasopharyngeal carcinoma ovarian cancer peripheral nervous system disease adrenal cortex carcinoma breast cancer Crohn disease Sjogren syndrome endometriosis large cell medulloblastoma lung cancer intellectual disability psoriasis Liver Cirrhosis, Experimental malignant ependymoma medulloblastoma nasopharyngeal carcinoma ovarian cancer peripheral nervous system disease adrenal cortex carcinoma breast cancer Crohn disease Sjogren syndrome endometriosis large cell medulloblastoma lung cancer malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma peripheral neuropathy atopic eczema breast carcinoma cutaneous lupus erythematosus tuberculosis eye disease interstitial cystitis malignant colon neoplasm malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor atypical teratoid rhabdoid tumor cancer schizophrenia ductal breast carcinoma in situ ulcerative colitis glioblastoma invasive ductal breast carcinoma lung adenocarcinoma
D	Pharos: P60006	astrocytic tumor osteosarcoma psoriasis
E [auth A]	Pharos: Q9H1A4	Alcoholic Intoxication, Chronic heart disease atopic eczema hypotrichosis glioblastoma
F [auth N]	Pharos: Q9UJX6	glioblastoma malignant ependymoma oligodendroglioma
I [auth K], Q	Pharos: Q13042	lymphoplasmacytic lymphoma nodular sclerosis classical Hodgkin lymphoma pancreatic ductal adenocarcinoma malignant colon neoplasm osteosarcoma Pick disease medulloblastoma ovarian cancer