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Pfs25 in complex with the human transmission blocking antibody 2586 External Resource: Annotation Chains Family Name Domain Identifier Architecture Possible Homology Homology Topology Family Provenance Source (Version) B [auth L] PF07654 e6phdL1 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like F: PF07654 ECOD (1.6) B [auth L] PF07686 e6phdL2 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like F: PF07686 ECOD (1.6) C PF06247 e6phdC3 A: few secondary structure elements X: EGF-like H: EGF-related T: EGF/Laminin F: PF06247 ECOD (1.6) C PF06247 e6phdC1 A: few secondary structure elements X: EGF-like H: Fibulin-4 EGF-like 1 domain (From Topology) T: Fibulin-4 EGF-like 1 domain F: PF06247 ECOD (1.6) A [auth H] PF07654 e6phdH1 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like F: PF07654 ECOD (1.6) A [auth H] PF07686 e6phdH2 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like F: PF07686 ECOD (1.6)
Chain Protein Name Description Organism Name Gene Allele Name(s) Domain Name(s) Receptor Type Receptor Description Provenance Source B [auth L] Fab 2586 L-LAMBDA Homo sapiens (human) IGLV3-25*02, IGLJ2*01, IGLJ3*01, IGLC2*01, IGLC2*02, IGLC3*04 V-DOMAIN V-LAMBDA, C-DOMAIN C-LAMBDA IG FAB-GAMMA-1_LAMBDA IMGT (202420-0) A [auth H] Fab 2586 VH-CH1 Homo sapiens (human) IGHV3-72*01, IGHJ6*04, IGHG1*01, IGHG1*02, IGHG1*04, IGHG1*05, IGHG1*12, IGHG1*14, IGHG1*13, IGHG1*09, IGHG1*10, IGHG1*07, IGHG1*11 V-DOMAIN VH, C-DOMAIN CH1 IG FAB-GAMMA-1_LAMBDA IMGT (202420-0)
Chain Chain Class Chain Subclass Chain Type Antigen Name(s) Provenance Source B [auth L] Light Chain IGLV3 Lambda 25 kda ookinete surface antigen SAbDab (2024-05-24) A [auth H] Heavy Chain IGHV3 - 25 kda ookinete surface antigen SAbDab (2024-05-24)
Chains Accession Name Description Comments Source PF06247 Pvs28 EGF domain (Plasmod_Pvs28) Pvs28 EGF domain This family consists of several ookinete surface proteins (Pvs28) from several species of Plasmodium. Pvs25 and Pvs28 are expressed on the surface of ookinetes. These proteins are potential candidates for vaccine and induce antibodies that block the ... This family consists of several ookinete surface proteins (Pvs28) from several species of Plasmodium. Pvs25 and Pvs28 are expressed on the surface of ookinetes. These proteins are potential candidates for vaccine and induce antibodies that block the infectivity of Plasmodium vivax in immunised animals [1]. The structure of this protein shows it is composed of four EGF domains [2]. Less Domain
Chains Polymer Molecular Function Biological Process Cellular Component B [auth L] 2586 Antibody Fab, Light Chain - - - 25 kDa ookinete surface antigen - - A [auth H] 2586 Antibody Fab, Heavy Chain - - -