Annotations: 6P74

Chains	Accession	Name	Description	Comments	Source
A	PF13175	AAA ATPase domain (AAA_15)	AAA ATPase domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	Domain
A	PF20469	Overcoming lysogenization defect protein-like, TOPRIM domain (OLD-like_TOPRIM)	Overcoming lysogenization defect protein-like, TOPRIM domain	This entry represents the topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well ...	This entry represents the topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as RNase activity [1,2] consists of an N-terminal ABC-type ATPase domain and a C-terminal Toprim domain. The nuclease activity of OLD is stimulated by ATP, though the ATPase activity is not DNA-dependent. The TOPRIM domain has two conserved motifs, one of which centres at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general acid in strand cleavage by nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function [3].	Domain

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Putative ATP-dependent endonuclease of the OLD family	nuclease activity hydrolase activity, acting on ester bonds hydrolase activity exonuclease activity catalytic activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding nuclease activity hydrolase activity, acting on ester bonds hydrolase activity exonuclease activity catalytic activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding metal ion binding	-	-

Chains	Accession	Name	Type
A	IPR034139	OLD protein-like, TOPRIM domain	Domain
A	IPR041685	AAA domain, group 15	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily