6LGQ

The crystal complex structure of histidine kinase and response regulator

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
AMR Gene: CARD Annotation
AMR Gene Family: CARD Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth D]	d6lgqd2	All alpha proteins	DNA/RNA-binding 3-helical bundle	C-terminal effector domain of the bipartite response regulators	automated matches	automated matches	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B [auth D]	d6lgqd1	Alpha and beta proteins (a/b)	Flavodoxin-like	CheY-like	automated matches	automated matches	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth D]	SCOP2B Superfamily	CheY-like	8035660	3001156	SCOP2B (2022-06-29)
B [auth D]	SCOP2B Superfamily	C-terminal effector domain of the bipartite response regulators	8075579	3001179	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	PF00512	e6lgqC1	A: alpha duplicates or obligate multimers	X: ROP-like	H: Homodimeric domain of signal transducing histidine kinase (From Topology)	T: Homodimeric domain of signal transducing histidine kinase	F: PF00512	ECOD (1.6)
A [auth C]	PF02518	e6lgqC2	A: a+b two layers	X: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like	H: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase (From Topology)	T: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	F: PF02518	ECOD (1.6)
B [auth D]	PF00486	e6lgqD2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF00486	ECOD (1.6)
B [auth D]	PF00072	e6lgqD1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: CheY-like	F: PF00072	ECOD (1.6)

AMR Gene: CARD Annotation CARD Database Homepage

Chains	Accession	Short Name	Description	Provenance Source (Version)
B [auth D]	ARO:3003841	kdpE	kdpE is a transcriptional activator that is part of the two-component system KdpD/KdpE that is studied for its regulatory role in potassium transport and has been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. kdpE regulates a range of virulence loci through direct promoter binding.	CARD (3.2.9)

AMR Gene Family: CARD Annotation CARD Database Homepage

Chains	Accession	Gene Family	Drug Class	Resistance Machanism	Provenance Source (Version)
B [auth D]	ARO:3004046	kdpDE	aminoglycoside antibiotic	antibiotic efflux	CARD (3.2.9)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C]	PF00512	His Kinase A (phospho-acceptor) domain (HisKA)	His Kinase A (phospho-acceptor) domain	Dimerisation and phospho-acceptor domain of histidine kinases.	Domain
A [auth C]	PF02518	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.	Domain
B [auth D]	PF00072	Response regulator receiver domain (Response_reg)	Response regulator receiver domain	This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.	Domain
B [auth D]	PF00486	Transcriptional regulatory protein, C terminal (Trans_reg_C)	Transcriptional regulatory protein, C terminal	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C]	Histidine kinase KdpD	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups identical protein binding protein binding protein homodimerization activity protein dimerization activity catalytic activity, acting on a protein small molecule sensor activity kinase activity protein kinase activity phosphotransferase activity, nitrogenous group as acceptor phosphotransferase activity, alcohol group as acceptor protein histidine kinase activity phosphorelay sensor kinase activity	cellular response to stimulus cellular response to inorganic substance cellular response to metal ion response to stimulus response to potassium ion response to inorganic substance cellular response to chemical stimulus response to metal ion response to chemical cellular process cellular response to potassium ion regulation of biological process regulation of cellular process signaling cellular response to stimulus cellular response to inorganic substance cellular response to metal ion response to stimulus response to potassium ion response to inorganic substance cellular response to chemical stimulus response to metal ion response to chemical cellular process cellular response to potassium ion regulation of biological process regulation of cellular process signaling biological regulation signal transduction cell communication	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane outer membrane-bounded periplasmic space cell envelope periplasmic space
B [auth D]	DNA-binding response regulator	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding cis-regulatory region sequence-specific DNA binding transcription regulatory region nucleic acid binding identical protein binding protein binding protein homodimerization activity protein dimerization activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding cis-regulatory region sequence-specific DNA binding transcription regulatory region nucleic acid binding identical protein binding protein binding protein homodimerization activity protein dimerization activity transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity molecular transducer activity phosphorelay response regulator activity	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex protein-DNA complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C]	IPR004358	Signal transduction histidine kinase-related protein, C-terminal	Domain
A [auth C]	IPR003852	Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal	Domain
A [auth C]	IPR003594	Histidine kinase/HSP90-like ATPase	Domain
A [auth C]	IPR036097	Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily	Homologous Superfamily
A [auth C]	IPR025201	Sensor protein KdpD, transmembrane domain	Domain
A [auth C]	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
A [auth C]	IPR003661	Signal transduction histidine kinase, dimerisation/phosphoacceptor domain	Domain
A [auth C]	IPR005467	Histidine kinase domain	Domain
A [auth C]	IPR003018	GAF domain	Domain
A [auth C]	IPR029016	GAF-like domain superfamily	Homologous Superfamily
A [auth C]	IPR038318	KdpD, transmembrane domain superfamily	Homologous Superfamily
A [auth C]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B [auth D]	IPR039420	Transcriptional regulatory protein WalR-like	Family
B [auth D]	IPR001867	OmpR/PhoB-type DNA-binding domain	Domain
B [auth D]	IPR011006	CheY-like superfamily	Homologous Superfamily
B [auth D]	IPR001789	Signal transduction response regulator, receiver domain	Domain
B [auth D]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.