6KYB

Crystal structure of Atg18 from Saccharomyces cerevisiae

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF21032	e6kybA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF21032	ECOD (1.6)
B	PF21032	e6kybB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF21032	ECOD (1.6)
C	PF21032	e6kybC1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF21032	ECOD (1.6)
D	PF21032	e6kybD1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF21032	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Autophagy-related protein 18	phosphatidylinositol-3,5-bisphosphate binding binding ion binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding protein binding ubiquitin binding ubiquitin-like protein binding phosphatidylinositol-4-phosphate binding phosphatidylinositol-3,5-bisphosphate binding binding ion binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding protein binding ubiquitin binding ubiquitin-like protein binding phosphatidylinositol-4-phosphate binding phosphatidylinositol-3-phosphate binding	localization cellular localization late endosome to vacuole transport transport establishment of localization in cell cellular process vacuolar transport intracellular transport establishment of localization vesicle-mediated transport protein localization establishment of protein localization nitrogen compound transport protein targeting localization cellular localization late endosome to vacuole transport transport establishment of localization in cell cellular process vacuolar transport intracellular transport establishment of localization vesicle-mediated transport protein localization establishment of protein localization nitrogen compound transport protein targeting establishment of protein localization to vacuole cytoplasm to vacuole targeting by the Cvt pathway cellular macromolecule localization process utilizing autophagic mechanism protein targeting to vacuole organic substance transport protein localization to vacuole establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle intracellular protein transport organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process biosynthetic process proteolysis organic substance biosynthetic process protein processing metabolic process protein metabolic process macromolecule metabolic process vacuolar protein processing autophagosome assembly catabolic process organelle assembly vacuole organization macroautophagy autophagy autophagosome organization cellular component biogenesis cellular component organization cellular catabolic process organelle organization cellular component assembly cellular component organization or biogenesis piecemeal microautophagy of the nucleus microautophagy nucleophagy autophagy of peroxisome pexophagy regulation of cellular process regulation of lipid metabolic process glycerophospholipid metabolic process lipid biosynthetic process regulation of primary metabolic process phospholipid metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process regulation of phosphatidylinositol biosynthetic process regulation of biosynthetic process phosphatidylinositol metabolic process regulation of biological process glycerophospholipid biosynthetic process biological regulation regulation of phospholipid metabolic process regulation of cellular metabolic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process regulation of phospholipid biosynthetic process regulation of cellular biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process glycerolipid metabolic process regulation of phosphorus metabolic process regulation of lipid biosynthetic process regulation of metabolic process lipid metabolic process 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process protein localization to phagophore assembly site positive regulation of organelle organization positive regulation of cellular component organization regulation of cellular component organization positive regulation of vacuole organization positive regulation of biological process regulation of vacuole organization regulation of organelle organization positive regulation of cellular process	intracellular anatomical structure phagophore cytoplasm cellular anatomical entity cytosol cell periphery phagophore assembly site membrane membrane phagophore assembly site extrinsic component of membrane protein-containing complex vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure phagophore cytoplasm cellular anatomical entity cytosol cell periphery phagophore assembly site membrane membrane phagophore assembly site extrinsic component of membrane protein-containing complex vacuolar membrane membrane-bounded organelle storage vacuole lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle organelle membrane fungal-type vacuole membrane endosome intracellular vesicle endomembrane system cytoplasmic vesicle vesicle endosome membrane cytoplasmic vesicle membrane vesicle membrane catalytic complex PAS complex membrane protein complex transferase complex phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups phosphatidylinositol 3-kinase complex, class III

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A, B, C, D	IPR048720	PROPPIN	Family
A, B, C, D	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A, B, C, D	IPR001680	WD40 repeat	Repeat

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.