6KOK

Crystal Structure of SNX11/SNX10-PXe Chimera

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00787	e6kokA1	A: a+b two layers	X: PX domain (From Topology)	H: PX domain (From Topology)	T: PX domain	F: PF00787	ECOD (1.6)
B	PF00787	e6kokB1	A: a+b two layers	X: PX domain (From Topology)	H: PX domain (From Topology)	T: PX domain	F: PF00787	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00787	PX domain (PX)	PX domain	PX domains bind to phosphoinositides.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Sorting nexin-11,Uncharacterized protein SNX10	binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding 1-phosphatidylinositol binding ATPase binding protein binding enzyme binding	protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process intracellular protein transport vesicle organization cellular component organization organelle organization cellular component organization or biogenesis multicellular organismal process system process digestion secretion digestive system process acid secretion gastric acid secretion cellular homeostasis homeostatic process protein localization to cilium protein localization to organelle protein localization to microtubule cytoskeleton protein localization to microtubule organizing center protein localization to cytoskeleton protein localization to centrosome import into cell endocytosis vesicle-mediated transport developmental process anatomical structure morphogenesis tooth eruption anatomical structure development odontogenesis animal organ development animal organ morphogenesis bone maturation bone mineralization bone mineralization involved in bone maturation developmental maturation tissue development multicellular organism development skeletal system development ossification anatomical structure maturation biomineral tissue development ossification involved in bone maturation animal organ maturation bone development system development organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component assembly cilium assembly cilium organization cell projection assembly inorganic ion homeostasis chemical homeostasis monoatomic ion homeostasis calcium ion homeostasis monoatomic cation homeostasis ruffle organization ruffle assembly myeloid leukocyte differentiation cellular developmental process hemopoiesis cell development myeloid cell differentiation cell differentiation osteoclast differentiation leukocyte differentiation multicellular organismal-level homeostasis tissue remodeling bone remodeling anatomical structure homeostasis tissue homeostasis bone resorption cellular response to stimulus response to organic substance response to stimulus response to cytokine response to leukemia inhibitory factor cellular response to leukemia inhibitory factor cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance endosome organization endomembrane system organization	membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle centrosome membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle centrosome microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle endosome membrane extrinsic component of organelle membrane extrinsic component of endosome membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane extrinsic component of membrane secretory granule secretory vesicle nucleus apical part of cell apical cytoplasm endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR043544	Sorting nexin-10/11	Family
A, B	IPR001683	Phox homology	Domain
A, B	IPR036871	PX domain superfamily	Homologous Superfamily
A, B	IPR001683	Phox homology	Domain
A, B	IPR043544	Sorting nexin-10/11	Family
A, B	IPR036871	PX domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9Y5X0	endometrial carcinoma epilepsy osteosarcoma autosomal recessive osteopetrosis 8 osteopetrosis liver cancer malignant ependymoma metabolic syndrome X pancreatic intraductal papillary-mucinous carcinoma astrocytic tumor Pick disease Sjogren syndrome cutaneous lupus erythematosus head and neck cancer Infantile malignant osteopetrosis endometrial carcinoma epilepsy osteosarcoma autosomal recessive osteopetrosis 8 osteopetrosis liver cancer malignant ependymoma metabolic syndrome X pancreatic intraductal papillary-mucinous carcinoma astrocytic tumor Pick disease Sjogren syndrome cutaneous lupus erythematosus head and neck cancer Infantile malignant osteopetrosis large cell medulloblastoma lung cancer malignant mesothelioma non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia atypical teratoid rhabdoid tumor primitive neuroectodermal tumor breast cancer ulcerative colitis gastric carcinoma hydrocephalus interstitial cystitis malignant colon neoplasm medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma Parkinson disease autosomal recessive osteopetrosis psoriasis chronic obstructive pulmonary disease glioblastoma IgA glomerulonephritis invasive ductal breast carcinoma liver neoplasm

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM				PX domain

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	MONOTOPIC MEMBRANE PROTEINS	Sorting Nexins	sorting nexin 11 SNX11-PXe domain in dimer form

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.