Annotations: 6JTG

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00350	e6jtgA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00350	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00350	Dynamin family (Dynamin_N)	Dynamin family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Dynamin-like 120 kDa protein, mitochondrial,OPA1 protein	ion binding binding anion binding phosphatidic acid binding phospholipid binding lipid binding small molecule binding phosphatidylglycerol binding cardiolipin binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding ion binding binding anion binding phosphatidic acid binding phospholipid binding lipid binding small molecule binding phosphatidylglycerol binding cardiolipin binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding organic cyclic compound binding purine nucleotide binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding cation binding magnesium ion binding metal ion binding cytoskeletal protein binding microtubule binding protein binding tubulin binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis establishment of organelle localization cellular localization organelle transport along microtubule transport establishment of mitochondrion localization intracellular transport cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis establishment of organelle localization cellular localization organelle transport along microtubule transport establishment of mitochondrion localization intracellular transport axonal transport establishment of localization localization mitochondrion localization establishment of mitochondrion localization, microtubule-mediated axo-dendritic transport mitochondrion transport along microtubule organelle localization establishment of localization in cell microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process axonal transport of mitochondrion organelle fusion organelle organization mitochondrial fusion mitochondrion organization regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death mitochondrial membrane organization membrane organization inner mitochondrial membrane organization cellular response to stimulus response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction regulation of cellular response to stress regulation of response to endoplasmic reticulum stress negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway regulation of signal transduction intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress regulation of intrinsic apoptotic signaling pathway intracellular signal transduction negative regulation of cell communication cell communication regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway cellular response to stress regulation of intracellular signal transduction regulation of response to stress response to stress negative regulation of apoptotic signaling pathway signal transduction intrinsic apoptotic signaling pathway response to endoplasmic reticulum stress negative regulation of response to endoplasmic reticulum stress regulation of signaling negative regulation of response to stimulus negative regulation of signal transduction apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway regulation of response to stimulus regulation of cell communication regulation of apoptotic signaling pathway cellular metabolic process cellular senescence metabolic process multicellular organismal process embryonic epithelial tube formation chordate embryonic development tube formation embryo development multicellular organism development epithelial tube formation tube morphogenesis primary neural tube formation embryo development ending in birth or egg hatching anatomical structure development epithelial tube morphogenesis system development developmental process morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium nervous system development tissue development anatomical structure morphogenesis tissue morphogenesis neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure regulation of cellular component organization apoptotic mitochondrial changes regulation of release of cytochrome c from mitochondria negative regulation of release of cytochrome c from mitochondria negative regulation of cellular component organization regulation of organelle organization release of cytochrome c from mitochondria negative regulation of organelle organization regulation of mitochondrion organization mitochondrial genome maintenance membrane tubulation sensory perception of light stimulus system process sensory perception nervous system process visual perception ribose phosphate metabolic process GTP metabolic process carbohydrate derivative metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process organic substance metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process purine nucleoside triphosphate metabolic process organonitrogen compound metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process organic cyclic compound metabolic process organophosphate metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process organelle fission mitochondrial fission	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane cytosol mitochondrial crista somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen organelle outer membrane bounding membrane of organelle mitochondrial outer membrane outer membrane polymeric cytoskeletal fiber cytoskeleton intracellular non-membrane-bounded organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton non-membrane-bounded organelle mitochondrial intermembrane space organelle envelope lumen neuron projection cytoplasm axon axon cytoplasm cytoplasmic region plasma membrane bounded cell projection cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001401	Dynamin, GTPase domain	Domain
A	IPR045817	Dynamin-like GTPase OPA1, C-terminal	Domain
A	IPR045063	Dynamin, N-terminal	Domain
A	IPR030381	Dynamin-type guanine nucleotide-binding (G) domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR022812	Dynamin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O60313	Behr syndrome optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy mitochondrial DNA depletion syndrome 14 (cardioencephalomyopathic type) autosomal dominant optic atrophy plus syndrome autosomal dominant optic atrophy, classic form autosomal dominant optic atrophy cardiomyopathy neurodegenerative disease Osteoarthrosis Deformans Pick disease schizophrenia astrocytic tumor breast cancer dental caries glioblastoma Behr syndrome optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy mitochondrial DNA depletion syndrome 14 (cardioencephalomyopathic type) autosomal dominant optic atrophy plus syndrome autosomal dominant optic atrophy, classic form autosomal dominant optic atrophy cardiomyopathy neurodegenerative disease Osteoarthrosis Deformans Pick disease schizophrenia astrocytic tumor breast cancer dental caries glioblastoma malignant glioma oligodendroglioma osteoarthritis osteosarcoma pilocytic astrocytoma tuberculosis atypical teratoid rhabdoid tumor glaucoma, normal tension, susceptibility to large cell medulloblastoma malignant mesothelioma osteoarthritis susceptibility 1 ovarian cancer progressive external ophthalmoplegia malignant ependymoma medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.