6JMT

Crystal structure of GIT/PIX complex

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01412,PF08518,PF12796	e6jmtA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF01412,PF08518,PF12796	ECOD (1.6)
B [auth D]	PF01412,PF08518,PF12796	e6jmtD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF01412,PF08518,PF12796	ECOD (1.6)
C [auth B]	PF01412,PF08518,PF12796	e6jmtB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF01412,PF08518,PF12796	ECOD (1.6)
D [auth C]	PF01412,PF08518,PF12796	e6jmtC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF01412,PF08518,PF12796	ECOD (1.6)
E	PF01412,PF08518,PF12796	e6jmtE1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF01412,PF08518,PF12796	ECOD (1.6)
F	PF01412,PF08518,PF12796	e6jmtF1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF01412,PF08518,PF12796	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth D], C [auth B], D [auth C], E, A, B [auth D], C [auth B], D [auth C], E, F	PF12796	Ankyrin repeats (3 copies) (Ank_2)	Ankyrin repeats (3 copies)	-	Repeat
A, B [auth D], C [auth B], D [auth C], E, A, B [auth D], C [auth B], D [auth C], E, F	PF08518	Spa2 homology domain (SHD) of GIT (GIT_SHD)	Spa2 homology domain (SHD) of GIT	-	Family
A, B [auth D], C [auth B], D [auth C], E, A, B [auth D], C [auth B], D [auth C], E, F	PF01412	Putative GTPase activating protein for Arf (ArfGap)	Putative GTPase activating protein for Arf	Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.	Domain
G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], L [auth N]	PF16614	Unstructured region two on RhoGEF 6 and 7 (RhoGEF67_u2)	Unstructured region two on RhoGEF 6 and 7	-	Disordered

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth D], C [auth B], D [auth C], E, A, B [auth D], C [auth B], D [auth C], E, F	ARF GTPase-activating protein GIT2	small GTPase binding protein binding binding enzyme binding GTPase binding protein-containing complex binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity cation binding small GTPase binding protein binding binding enzyme binding GTPase binding protein-containing complex binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity cation binding ion binding metal ion binding small molecule binding	developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process response to stimulus signaling biological regulation regulation of signal transduction cell communication regulation of response to stimulus regulation of cell communication G protein-coupled receptor signaling pathway cellular process signal transduction regulation of G protein-coupled receptor signaling pathway trans-synaptic signaling modulation of chemical synaptic transmission cell-cell signaling presynaptic modulation of chemical synaptic transmission chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction ARF protein signal transduction intracellular signal transduction regulation of intracellular signal transduction regulation of ARF protein signal transduction intracellular signaling cassette synaptic vesicle recycling localization cellular localization transport establishment of localization in cell synaptic vesicle cycle establishment of localization vesicle-mediated transport vesicle-mediated transport in synapse regulation of localization regulated exocytosis synaptic vesicle exocytosis regulation of regulated secretory pathway regulation of secretion by cell secretion by cell signal release neurotransmitter secretion regulation of transport secretion regulation of neurotransmitter transport regulation of synaptic vesicle exocytosis export from cell neurotransmitter transport regulation of vesicle-mediated transport regulation of secretion signal release from synapse exocytosis regulation of neurotransmitter secretion regulation of exocytosis behavior response to stress multicellular organismal response to stress response to pain behavioral response to pain	axon synapse neuron projection axon terminus cellular anatomical entity plasma membrane bounded cell projection presynapse cell projection distal axon calyx of Held cell junction neuron projection terminus
G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], L [auth N]	beta PIX	cytoskeletal protein binding protein binding binding gamma-tubulin binding tubulin binding kinase binding enzyme binding protein kinase binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity	developmental process multicellular organismal process cellular developmental process glial cell migration nervous system development neurogenesis multicellular organism development gliogenesis cell differentiation anatomical structure development astrocyte cell migration cellular process cell migration cell motility developmental process multicellular organismal process cellular developmental process glial cell migration nervous system development neurogenesis multicellular organism development gliogenesis cell differentiation anatomical structure development astrocyte cell migration cellular process cell migration cell motility system development lamellipodium assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis cellular component assembly lamellipodium organization cellular component organization or biogenesis cell projection assembly postsynapse organization actin cytoskeleton organization postsynaptic cytoskeleton organization organelle organization cell junction organization postsynaptic actin cytoskeleton organization actin filament-based process synapse organization cytoskeleton organization positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity biological regulation positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death positive regulation of cellular process regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization regulation of cellular component organization microtubule cytoskeleton organization negative regulation of biological process regulation of protein-containing complex assembly microtubule polymerization or depolymerization protein-containing complex assembly negative regulation of cellular process negative regulation of microtubule nucleation negative regulation of protein polymerization negative regulation of supramolecular fiber organization protein polymerization negative regulation of cellular component organization negative regulation of microtubule polymerization or depolymerization protein-containing complex organization negative regulation of cytoskeleton organization regulation of microtubule-based process negative regulation of microtubule polymerization microtubule polymerization regulation of cellular component biogenesis regulation of microtubule nucleation regulation of organelle organization negative regulation of protein-containing complex assembly microtubule nucleation negative regulation of organelle organization regulation of microtubule polymerization regulation of protein polymerization regulation of supramolecular fiber organization microtubule-based process supramolecular fiber organization regulation of microtubule cytoskeleton organization hemopoiesis cell development hematopoietic progenitor cell differentiation positive regulation of cell communication regulation of localization nitrogen compound transport cell communication localization regulation of biological quality regulation of peptide hormone secretion regulation of hormone levels organic substance transport positive regulation of peptide hormone secretion establishment of localization regulation of secretion positive regulation of growth hormone secretion regulation of hormone secretion regulation of peptide secretion transport signaling positive regulation of secretion by cell hormone secretion peptide secretion secretion by cell regulation of secretion by cell positive regulation of hormone secretion positive regulation of secretion amide transport signal release positive regulation of peptide secretion regulation of signaling growth hormone secretion secretion regulation of transport regulation of growth hormone secretion regulation of peptide transport cell-cell signaling export from cell peptide transport positive regulation of transport peptide hormone secretion hormone transport regulation of cell communication positive regulation of signaling cellular response to stimulus small GTPase-mediated signal transduction response to stimulus intracellular signal transduction intracellular signaling cassette signal transduction presynapse organization presynaptic actin cytoskeleton organization presynaptic cytoskeleton organization	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction cell projection cell leading edge plasma membrane bounded cell projection lamellipodium cell periphery cell cortex intracellular anatomical structure cytoplasm intracellular organelle anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction cell projection cell leading edge plasma membrane bounded cell projection lamellipodium cell periphery cell cortex intracellular anatomical structure cytoplasm intracellular organelle centrosome microtubule organizing center cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle cytosol plasma membrane membrane growth cone axon distal axon neuron projection site of polarized growth protein-containing complex GABA-ergic synapse synapse ruffle storage vacuole membrane-bounded organelle vacuole intracellular membrane-bounded organelle mitotic spindle spindle mitotic spindle pole spindle pole postsynapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth D], C [auth B], D [auth C], E, A, B [auth D], C [auth B], D [auth C], E, F	IPR002110	Ankyrin repeat	Repeat
A, B [auth D], C [auth B], D [auth C], E, A, B [auth D], C [auth B], D [auth C], E, F	IPR013724	GIT, Spa2 homology (SHD) domain	Domain
A, B [auth D], C [auth B], D [auth C], E, A, B [auth D], C [auth B], D [auth C], E, F	IPR022018	ARF GTPase-activating protein GIT1, C-terminal	Domain
A, B [auth D], C [auth B], D [auth C], E, A, B [auth D], C [auth B], D [auth C], E, F	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A, B [auth D], C [auth B], D [auth C], E, A, B [auth D], C [auth B], D [auth C], E, F	IPR037278	ARFGAP/RecO-like zinc finger	Homologous Superfamily
A, B [auth D], C [auth B], D [auth C], E, A, B [auth D], C [auth B], D [auth C], E, F	IPR001164	Arf GTPase activating protein	Domain
A, B [auth D], C [auth B], D [auth C], E, A, B [auth D], C [auth B], D [auth C], E, F	IPR047161	ARF GTPase-activating protein Git-like	Family
A, B [auth D], C [auth B], D [auth C], E, A, B [auth D], C [auth B], D [auth C], E, F	IPR038508	ArfGAP domain superfamily	Homologous Superfamily
G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], L [auth N]	IPR001849	Pleckstrin homology domain	Domain
G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], L [auth N]	IPR000219	Dbl homology (DH) domain	Domain
G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], L [auth N]	IPR035789	Rho guanine nucleotide exchange factor 7, SH3 domain	Domain
G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], L [auth N]	IPR001715	Calponin homology domain	Domain
G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], L [auth N]	IPR036028	SH3-like domain superfamily	Homologous Superfamily
G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], L [auth N]	IPR032409	Rho guanine nucleotide exchange factor 6/7, coiled-coil domain	Domain
G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], L [auth N]	IPR011993	PH-like domain superfamily	Homologous Superfamily
G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], L [auth N]	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	Conserved Site
G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], L [auth N]	IPR001452	SH3 domain	Domain
G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], L [auth N]	IPR036872	CH domain superfamily	Homologous Superfamily
G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], L [auth N]	IPR035899	Dbl homology (DH) domain superfamily	Homologous Superfamily
G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], G [auth I], H [auth J], I [auth K], J [auth L], K [auth M], L [auth N]	IPR046376	RhoGEF 6/7, PH domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.

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6JMT

Crystal structure of GIT/PIX complex

External Resource: Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage