Annotations: 6I5Z

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08100	e6i5zA2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF08100	ECOD (1.6)
A	PF00891	e6i5zA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: PF00891	ECOD (1.6)
B	PF08100	e6i5zB1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF08100	ECOD (1.6)
B	PF00891	e6i5zB2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: PF00891	ECOD (1.6)
C	PF08100	e6i5zC2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF08100	ECOD (1.6)
C	PF00891	e6i5zC1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: PF00891	ECOD (1.6)
D	PF08100	e6i5zD1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF08100	ECOD (1.6)
D	PF00891	e6i5zD2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: PF00891	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.150	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Vaccinia Virus protein VP39	CATH (utative)
B	3.40.50.150	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Vaccinia Virus protein VP39	CATH (utative)
C	3.40.50.150	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Vaccinia Virus protein VP39	CATH (utative)
D	3.40.50.150	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Vaccinia Virus protein VP39	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF08100	Dimerisation domain (Dimerisation)	Dimerisation domain	This domain is found at the N-terminus of a variety of plant O-methyltransferases. It has been shown to mediate dimerisation of these proteins [1].	Domain
A, B, C, D	PF00891	O-methyltransferase domain (Methyltransf_2)	O-methyltransferase domain	This family includes a range of O-methyltransferases. These enzymes utilise S-adenosyl methionine.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	O-methyltransferase 1	transferase activity, transferring one-carbon groups tetrahydrocolumbamine 2-O-methyltransferase activity transferase activity methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity catalytic activity O-methyltransferase activity (S)-scoulerine 9-O-methyltransferase activity protein binding binding protein dimerization activity	organonitrogen compound metabolic process alkaloid biosynthetic process benzyl isoquinoline alkaloid biosynthetic process isoquinoline alkaloid biosynthetic process organonitrogen compound biosynthetic process alkaloid metabolic process isoquinoline alkaloid metabolic process secondary metabolic process benzyl isoquinoline alkaloid metabolic process organic substance metabolic process secondary metabolite biosynthetic process biosynthetic process organic substance biosynthetic process metabolic process organonitrogen compound metabolic process alkaloid biosynthetic process benzyl isoquinoline alkaloid biosynthetic process isoquinoline alkaloid biosynthetic process organonitrogen compound biosynthetic process alkaloid metabolic process isoquinoline alkaloid metabolic process secondary metabolic process benzyl isoquinoline alkaloid metabolic process organic substance metabolic process secondary metabolite biosynthetic process biosynthetic process organic substance biosynthetic process metabolic process methylation	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR001077	O-methyltransferase domain	Domain
A, B, C, D	IPR016461	O-methyltransferase COMT-type	Family
A, B, C, D	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A, B, C, D	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, B, C, D	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A, B, C, D	IPR012967	Plant methyltransferase dimerisation domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.