Annotations: 6HUL

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6hula_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Ribulose-phoshate binding barrel	automated matches	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2 Family	Tryptophan synthase beta subunit-like PLP-dependent enzymes	8098719	4000798	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Tryptophan synthase beta subunit-like PLP-dependent enzymes	8098720	3001427	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00290	e6hulA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00290	ECOD (1.6)
B	PF00291	e6hulB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Tryptophan synthase beta subunit-like PLP-dependent enzymes (From Topology)	T: Tryptophan synthase beta subunit-like PLP-dependent enzymes	F: PF00291	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.50.1100	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00290	Tryptophan synthase alpha chain (Trp_syntA)	Tryptophan synthase alpha chain	-	Domain
B	PF00291	Pyridoxal-phosphate dependent enzyme (PALP)	Pyridoxal-phosphate dependent enzyme	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Tryptophan synthase alpha chain	hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity tryptophan synthase activity	oxoacid metabolic process cellular biosynthetic process organonitrogen compound biosynthetic process indole-containing compound metabolic process amino acid metabolic process organic acid biosynthetic process organic acid metabolic process alpha-amino acid metabolic process carboxylic acid biosynthetic process biogenic amine biosynthetic process organic substance metabolic process tryptophan biosynthetic process indole-containing compound biosynthetic process organic substance biosynthetic process indolalkylamine metabolic process oxoacid metabolic process cellular biosynthetic process organonitrogen compound biosynthetic process indole-containing compound metabolic process amino acid metabolic process organic acid biosynthetic process organic acid metabolic process alpha-amino acid metabolic process carboxylic acid biosynthetic process biogenic amine biosynthetic process organic substance metabolic process tryptophan biosynthetic process indole-containing compound biosynthetic process organic substance biosynthetic process indolalkylamine metabolic process small molecule metabolic process indolalkylamine biosynthetic process organonitrogen compound metabolic process aromatic amino acid family biosynthetic process aromatic amino acid metabolic process small molecule biosynthetic process cellular metabolic process carboxylic acid metabolic process primary metabolic process tryptophan metabolic process organic cyclic compound metabolic process amine metabolic process amino acid biosynthetic process biosynthetic process amine biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process biogenic amine metabolic process alpha-amino acid biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol
B	Tryptophan synthase beta chain 1	hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity tryptophan synthase activity vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding binding organic cyclic compound binding anion binding heterocyclic compound binding small molecule binding hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity tryptophan synthase activity vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding binding organic cyclic compound binding anion binding heterocyclic compound binding small molecule binding L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity	oxoacid metabolic process cellular biosynthetic process organonitrogen compound biosynthetic process indole-containing compound metabolic process amino acid metabolic process organic acid biosynthetic process organic acid metabolic process alpha-amino acid metabolic process carboxylic acid biosynthetic process biogenic amine biosynthetic process organic substance metabolic process tryptophan biosynthetic process indole-containing compound biosynthetic process organic substance biosynthetic process indolalkylamine metabolic process oxoacid metabolic process cellular biosynthetic process organonitrogen compound biosynthetic process indole-containing compound metabolic process amino acid metabolic process organic acid biosynthetic process organic acid metabolic process alpha-amino acid metabolic process carboxylic acid biosynthetic process biogenic amine biosynthetic process organic substance metabolic process tryptophan biosynthetic process indole-containing compound biosynthetic process organic substance biosynthetic process indolalkylamine metabolic process small molecule metabolic process indolalkylamine biosynthetic process organonitrogen compound metabolic process aromatic amino acid family biosynthetic process aromatic amino acid metabolic process small molecule biosynthetic process cellular metabolic process carboxylic acid metabolic process primary metabolic process tryptophan metabolic process organic cyclic compound metabolic process amine metabolic process amino acid biosynthetic process biosynthetic process amine biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process biogenic amine metabolic process alpha-amino acid biosynthetic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002028	Tryptophan synthase, alpha chain	Family
A	IPR011060	Ribulose-phosphate binding barrel	Homologous Superfamily
A	IPR018204	Tryptophan synthase, alpha chain, active site	Active Site
A	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily
B	IPR023026	Tryptophan synthase beta chain/beta chain-like	Family
B	IPR036052	Tryptophan synthase beta chain-like, PALP domain superfamily	Homologous Superfamily
B	IPR006653	Tryptophan synthase, beta chain, conserved site	Conserved Site
B	IPR001926	Tryptophan synthase beta chain-like, PALP domain	Domain
B	IPR006654	Tryptophan synthase, beta chain	Family
B	IPR006316	Tryptophan synthase, beta chain-like	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.