6HRL

Crystal structure of the Kelch domain of human KLHL17

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6hrla_	All beta proteins	6-bladed beta-propeller	Kelch motif	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d6hrlb_	All beta proteins	6-bladed beta-propeller	Kelch motif	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	BTB/kelch domain-like	8084982	4003219	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Kelch motif	8084983	3000448	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Kelch motif	8084983	3000448	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01344	e6hrlA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF01344	ECOD (1.6)
B	PF01344	e6hrlB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF01344	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.120.10.80	Mainly Beta	6 Propeller	Neuraminidase	Kelch-type beta propeller	CATH (utative)
B	2.120.10.80	Mainly Beta	6 Propeller	Neuraminidase	Kelch-type beta propeller	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01344	Kelch motif (Kelch_1)	Kelch motif	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Kelch-like protein 17	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding molecular adaptor activity POZ domain binding protein domain specific binding	regulation protein catabolic process at synapse regulation of biological process catabolic process biological regulation metabolic process regulation of catabolic process regulation of metabolic process regulation protein catabolic process at postsynapse organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification protein metabolic process regulation protein catabolic process at synapse regulation of biological process catabolic process biological regulation metabolic process regulation of catabolic process regulation of metabolic process regulation protein catabolic process at postsynapse organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular process cellular component organization or biogenesis cytoskeleton organization	intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity actin cytoskeleton non-membrane-bounded organelle postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse cell junction intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity actin cytoskeleton non-membrane-bounded organelle postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse cell junction asymmetric synapse somatodendritic compartment cell body neuronal cell body extracellular region extracellular space glutamatergic synapse neuron projection cytoplasm neuron projection cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection dendrite cytoplasm cell projection dendrite dendritic tree cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR017096	BTB-kelch protein	Family
A, B	IPR000210	BTB/POZ domain	Domain
A, B	IPR015915	Kelch-type beta propeller	Homologous Superfamily
A, B	IPR006652	Kelch repeat type 1	Repeat
A, B	IPR011043	Galactose oxidase/kelch, beta-propeller	Homologous Superfamily
A, B	IPR011705	BTB/Kelch-associated	Domain
A, B	IPR011333	SKP1/BTB/POZ domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q6TDP4	exocrine pancreatic carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.