6FSF

Crystal structure of the tandem PX-PH-domains of Bem3 from Saccharomyces cerevisiae

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00169	e6fsfA1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF00169	ECOD (1.6)
A	PF00787	e6fsfA2	A: a+b two layers	X: PX domain (From Topology)	H: PX domain (From Topology)	T: PX domain	F: PF00787	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00787	PX domain (PX)	PX domain	PX domains bind to phosphoinositides.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	GTPase-activating protein BEM3	GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity binding phospholipid binding lipid binding phosphatidylinositol-3-phosphate binding phosphatidylinositol phosphate binding phosphatidylinositol binding	cellular response to stimulus regulation of cellular process small GTPase-mediated signal transduction negative regulation of Rho protein signal transduction response to stimulus signaling negative regulation of signaling regulation of small GTPase mediated signal transduction negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction intracellular signal transduction Rho protein signal transduction negative regulation of cell communication cell communication cellular response to stimulus regulation of cellular process small GTPase-mediated signal transduction negative regulation of Rho protein signal transduction response to stimulus signaling negative regulation of signaling regulation of small GTPase mediated signal transduction negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction intracellular signal transduction Rho protein signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette negative regulation of cellular process signal transduction regulation of biological process regulation of signaling negative regulation of response to stimulus biological regulation negative regulation of small GTPase mediated signal transduction regulation of Rho protein signal transduction negative regulation of signal transduction regulation of response to stimulus regulation of cell communication cellular process establishment of cell polarity establishment or maintenance of cell polarity cellular component organization organelle organization septin ring organization septin cytoskeleton organization cellular component organization or biogenesis cytoskeleton organization	incipient cellular bud site cellular anatomical entity site of polarized growth cellular bud cellular bud tip cell periphery cell cortex intracellular anatomical structure cytoplasm cell projection mating projection cell tip mating projection tip cell pole incipient cellular bud site cellular anatomical entity site of polarized growth cellular bud cellular bud tip cell periphery cell cortex intracellular anatomical structure cytoplasm cell projection mating projection cell tip mating projection tip cell pole plasma membrane bounded cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000198	Rho GTPase-activating protein domain	Domain
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR001683	Phox homology	Domain
A	IPR036871	PX domain superfamily	Homologous Superfamily
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR008936	Rho GTPase activation protein	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.