Annotations: 6FN6

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13602	e6fn6A3	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF13602	ECOD (1.6)
A	F_UNCLASSIFIED	e6fn6A4	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF21089	e6fn6A5	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF21089	ECOD (1.6)
A	PF00107	e6fn6A1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
A	PF08659	e6fn6A2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF08659	ECOD (1.6)
A	PF21149	e6fn6A6	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF21149	ECOD (1.6)
A	F_UNCLASSIFIED	e6fn6A7	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF13602	e6fn6B3	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF13602	ECOD (1.6)
B	F_UNCLASSIFIED	e6fn6B4	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF21089	e6fn6B5	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF21089	ECOD (1.6)
B	PF00107	e6fn6B1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
B	PF08659	e6fn6B2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF08659	ECOD (1.6)
B	PF21149	e6fn6B6	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF21149	ECOD (1.6)
B	F_UNCLASSIFIED	e6fn6B7	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13602	Zinc-binding dehydrogenase (ADH_zinc_N_2)	Zinc-binding dehydrogenase	-	Domain
A, B	PF21089	Polyketide synthase dehydratase domain (PKS_DH_N)	Polyketide synthase dehydratase domain	This domain is part of a dehydratase domain found in diverse PKS enzymes. This domain adopts a HotDog fold.	Domain
A, B	PF21149	Fatty acid synthase, pseudo-KR domain (FAS_pseudo-KR)	Fatty acid synthase, pseudo-KR domain	Fatty acid synthase is a multifunctional enzyme that catalyses the de novo biosynthesis of long-chain saturated fatty acids, starting from acetyl-CoA and malonyl-CoA in the presence of NADPH [1-3]. This entry represents the pseudo-ketoreductase (pseu ...	Fatty acid synthase is a multifunctional enzyme that catalyses the de novo biosynthesis of long-chain saturated fatty acids, starting from acetyl-CoA and malonyl-CoA in the presence of NADPH [1-3]. This entry represents the pseudo-ketoreductase (pseudo-KR) domain which is catalytically inactive and supports the integrity of the active KR domain [1,3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Fatty acid synthase 1, isoform A	(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors acetyltransferase activity acyltransferase activity (3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors acetyltransferase activity acyltransferase activity [acyl-carrier-protein] S-acetyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity S-acetyltransferase activity S-acyltransferase activity vitamin binding amide binding modified amino acid binding binding phosphopantetheine binding small molecule binding fatty acyl-[ACP] hydrolase activity hydrolase activity, acting on ester bonds thiolester hydrolase activity hydrolase activity 3-oxoacyl-[acyl-carrier-protein] synthase activity fatty acid synthase activity (3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity	response to organic substance response to carbohydrate response to stimulus response to sucrose response to disaccharide response to chemical response to oxygen-containing compound neutral lipid metabolic process neutral lipid biosynthetic process cellular biosynthetic process cellular metabolic process lipid biosynthetic process primary metabolic process acylglycerol biosynthetic process response to organic substance response to carbohydrate response to stimulus response to sucrose response to disaccharide response to chemical response to oxygen-containing compound neutral lipid metabolic process neutral lipid biosynthetic process cellular biosynthetic process cellular metabolic process lipid biosynthetic process primary metabolic process acylglycerol biosynthetic process organic substance metabolic process biosynthetic process glycerolipid biosynthetic process triglyceride metabolic process triglyceride biosynthetic process cellular lipid metabolic process organic substance biosynthetic process metabolic process cellular process glycerolipid metabolic process acylglycerol metabolic process lipid metabolic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process small molecule metabolic process monocarboxylic acid metabolic process cellular response to stimulus cellular response to oxygen-containing compound cellular response to sucrose stimulus cellular response to carbohydrate stimulus cellular response to chemical stimulus cellular response to disaccharide stimulus cellular response to organic substance carbohydrate metabolic process energy derivation by oxidation of organic compounds glycogen metabolic process generation of precursor metabolites and energy glucan metabolic process polysaccharide metabolic process energy reserve metabolic process macromolecule metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase	Homologous Superfamily
A, B	IPR014031	Beta-ketoacyl synthase, C-terminal	Domain
A, B	IPR020807	Polyketide synthase, dehydratase domain	Domain
A, B	IPR014030	Beta-ketoacyl synthase, N-terminal	Domain
A, B	IPR049552	Polyketide synthase, dehydratase domain, N-terminal	Domain
A, B	IPR049391	Fatty acid synthase, pseudo-KR domain	Domain
A, B	IPR020843	Polyketide synthase, enoylreductase domain	Domain
A, B	IPR013968	Polyketide synthase, ketoreductase domain	Domain
A, B	IPR016036	Malonyl-CoA ACP transacylase, ACP-binding	Homologous Superfamily
A, B	IPR020806	Polyketide synthase, phosphopantetheine-binding domain	Domain
A, B	IPR014043	Acyl transferase	Domain
A, B	IPR020841	Polyketide synthase, beta-ketoacyl synthase domain	Domain
A, B	IPR036736	ACP-like superfamily	Homologous Superfamily
A, B	IPR032821	Polyketide synthase, C-terminal extension	Domain
A, B	IPR011032	GroES-like superfamily	Homologous Superfamily
A, B	IPR009081	Phosphopantetheine binding ACP domain	Domain
A, B	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily
A, B	IPR016039	Thiolase-like	Homologous Superfamily
A, B	IPR001227	Acyl transferase domain superfamily	Homologous Superfamily
A, B	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B	IPR018201	Beta-ketoacyl synthase, active site	Active Site
A, B	IPR042104	Polyketide synthase, dehydratase domain superfamily	Homologous Superfamily
A, B	IPR049900	Polyketide/metazoan fatty acid synthase, dehydratase domain	Domain
A, B	IPR001031	Thioesterase	Domain