Annotations: 6BK5

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02761	e6bk5A3	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF02761	ECOD (1.6)
A	PF02262	e6bk5A1	A: alpha bundles	X: N-cbl like	H: N-terminal domain of cbl (N-cbl) (From Topology)	T: N-terminal domain of cbl (N-cbl)	F: PF02262	ECOD (1.6)
A	PF02762	e6bk5A2	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: PF02762	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02262	CBL proto-oncogene N-terminal domain 1 (Cbl_N)	CBL proto-oncogene N-terminal domain 1	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated ...	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. Cbl_N is comprised of 3 structural domains of which this is the first - a four helix bundle.	Domain
A	PF02762	CBL proto-oncogene N-terminus, SH2-like domain (Cbl_N3)	CBL proto-oncogene N-terminus, SH2-like domain	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated ...	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the C-terminal SH2 domain.	Domain
A	PF02761	CBL proto-oncogene N-terminus, EF hand-like domain (Cbl_N2)	CBL proto-oncogene N-terminus, EF hand-like domain	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated ...	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the central EF hand domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Ubiquitin Ligase Cbl	SH3 domain binding protein binding binding protein domain specific binding cation binding ion binding calcium ion binding metal ion binding small molecule binding protein tyrosine kinase binding kinase binding signaling receptor binding receptor tyrosine kinase binding enzyme binding SH3 domain binding protein binding binding protein domain specific binding cation binding ion binding calcium ion binding metal ion binding small molecule binding protein tyrosine kinase binding kinase binding signaling receptor binding receptor tyrosine kinase binding enzyme binding protein kinase binding phosphoprotein binding phosphotyrosine residue binding protein phosphorylated amino acid binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity	regulation of signaling regulation of biological process signaling biological regulation cellular response to stimulus regulation of cellular process cell surface receptor signaling pathway response to stimulus cellular process signal transduction cell communication	cell periphery plasma membrane membrane cellular anatomical entity membrane microdomain membrane raft

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017907	Zinc finger, RING-type, conserved site	Conserved Site
A	IPR024162	Adaptor protein Cbl	Family
A	IPR036860	SH2 domain superfamily	Homologous Superfamily
A	IPR014741	Adaptor protein Cbl, EF hand-like	Domain
A	IPR024159	Adaptor protein Cbl, PTB domain	Domain
A	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A	IPR014742	Adaptor protein Cbl, SH2-like domain	Domain
A	IPR036537	Adaptor protein Cbl, N-terminal domain superfamily	Homologous Superfamily
A	IPR003153	Adaptor protein Cbl, N-terminal helical	Domain
A	IPR009060	UBA-like superfamily	Homologous Superfamily
A	IPR001841	Zinc finger, RING-type	Domain
A	IPR011992	EF-hand domain pair	Homologous Superfamily
A	IPR015940	Ubiquitin-associated domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.