6B9T

Crystal structure of MPnS with substrate 2-hydroxyethylphosphonate (2-HEP) and Fe(II) bound

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	F_UNCLASSIFIED	e6b9tB2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e6b9tB4	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF01381	e6b9tB1	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF01381	ECOD (1.6)
D	F_UNCLASSIFIED	e6b9tD1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e6b9tD3	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF01381	e6b9tD2	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF01381	ECOD (1.6)
F	F_UNCLASSIFIED	e6b9tF2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: F_UNCLASSIFIED	ECOD (1.6)
F	F_UNCLASSIFIED	e6b9tF4	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: F_UNCLASSIFIED	ECOD (1.6)
F	PF01381	e6b9tF1	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF01381	ECOD (1.6)
A	F_UNCLASSIFIED	e6b9tA1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e6b9tA2	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF01381	e6b9tA3	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF01381	ECOD (1.6)
C	F_UNCLASSIFIED	e6b9tC3	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e6b9tC4	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF01381	e6b9tC2	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF01381	ECOD (1.6)
E	F_UNCLASSIFIED	e6b9tE4	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e6b9tE3	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: F_UNCLASSIFIED	ECOD (1.6)
E	PF01381	e6b9tE2	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF01381	ECOD (1.6)
G	F_UNCLASSIFIED	e6b9tG2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: F_UNCLASSIFIED	ECOD (1.6)
G	F_UNCLASSIFIED	e6b9tG1	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: F_UNCLASSIFIED	ECOD (1.6)
G	PF01381	e6b9tG4	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF01381	ECOD (1.6)
H	F_UNCLASSIFIED	e6b9tH2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: F_UNCLASSIFIED	ECOD (1.6)
H	F_UNCLASSIFIED	e6b9tH1	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: F_UNCLASSIFIED	ECOD (1.6)
H	PF01381	e6b9tH4	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF01381	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF01381	Helix-turn-helix (HTH_3)	Helix-turn-helix	This large family of DNA binding helix-turn helix proteins includes Cro Swiss:P03036 and CI Swiss:P03034. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be ...	This large family of DNA binding helix-turn helix proteins includes Cro Swiss:P03036 and CI Swiss:P03034. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Methylphosphonate synthase	DNA binding binding organic cyclic compound binding nucleic acid binding oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen catalytic activity dioxygenase activity cation binding transition metal ion binding iron ion binding ion binding ferrous iron binding DNA binding binding organic cyclic compound binding nucleic acid binding oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen catalytic activity dioxygenase activity cation binding transition metal ion binding iron ion binding ion binding ferrous iron binding metal ion binding small molecule binding transcription regulator activity DNA-binding transcription factor activity	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process oxoacid metabolic process organic acid metabolic process organic phosphonate biosynthetic process organic phosphonate metabolic process small molecule metabolic process phosphorus metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR001387	Cro/C1-type helix-turn-helix domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR011051	RmlC-like cupin domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR010982	Lambda repressor-like, DNA-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR014710	RmlC-like jelly roll fold	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.

Prepare Data

Validate Data

Deposit Data

Help and Resources

6B9T

Crystal structure of MPnS with substrate 2-hydroxyethylphosphonate (2-HEP) and Fe(II) bound

External Resource: Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage