5ZI6

The RING domain structure of MEX-3C

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13920	e5zi6A1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: PF13920	ECOD (1.6)
B	PF13920	e5zi6B1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: PF13920	ECOD (1.6)
C	PF13920	e5zi6C1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: PF13920	ECOD (1.6)
D	PF13920	e5zi6D1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: PF13920	ECOD (1.6)
E	PF13920	e5zi6E1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: PF13920	ECOD (1.6)
F	PF13920	e5zi6F1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: PF13920	ECOD (1.6)
G	PF13920	e5zi6G1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: PF13920	ECOD (1.6)
H	PF13920	e5zi6H1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: PF13920	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF13920	Zinc finger, C3HC4 type (RING finger) (zf-C3HC4_3)	Zinc finger, C3HC4 type (RING finger)	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	RNA-binding E3 ubiquitin-protein ligase MEX3C	RNA binding binding organic cyclic compound binding nucleic acid binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity cation binding RNA binding binding organic cyclic compound binding nucleic acid binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity cation binding ion binding metal ion binding small molecule binding	developmental process multicellular organismal process cellular developmental process connective tissue development developmental cell growth developmental growth chondrocyte hypertrophy growth animal organ development cell development tissue development cell growth multicellular organism development skeletal system development cell differentiation developmental process multicellular organismal process cellular developmental process connective tissue development developmental cell growth developmental growth chondrocyte hypertrophy growth animal organ development cell development tissue development cell growth multicellular organism development skeletal system development cell differentiation anatomical structure development chondrocyte differentiation cellular process chondrocyte development cartilage development system development fat cell differentiation regulation of biological process regulation of cellular process regulation of developmental process biological regulation regulation of cell differentiation regulation of fat cell differentiation multicellular organismal-level homeostasis homeostatic process energy homeostasis	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR047226	RNA-binding protein MEX-3, second type I KH domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR047227	RNA-binding protein MEX3	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR004087	K Homology domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR047228	RNA-binding protein MEX-3, first type I KH domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036612	K Homology domain, type 1 superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR001841	Zinc finger, RING-type	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR004088	K Homology domain, type 1	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H	Pharos: Q5U5Q3	juvenile idiopathic arthritis atrial fibrillation plasma cell myeloma sarcoidosis allergic rhinitis atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma malignant pancreatic neoplasm osteosarcoma primitive neuroectodermal tumor Sjogren syndrome astrocytic tumor B-cell chronic lymphocytic leukemia hepatocellular carcinoma juvenile idiopathic arthritis atrial fibrillation plasma cell myeloma sarcoidosis allergic rhinitis atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma malignant pancreatic neoplasm osteosarcoma primitive neuroectodermal tumor Sjogren syndrome astrocytic tumor B-cell chronic lymphocytic leukemia hepatocellular carcinoma Juvenile psoriatic arthritis malignant ependymoma medulloblastoma ovarian cancer rheumatoid arthritis tuberculosis exocrine pancreatic carcinoma malignant glioma oligodendroglioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.