Annotations: 5YI4

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF04880	NUDE protein, C-terminal conserved region (NUDE_C)	NUDE protein, C-terminal conserved region	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Disrupted in schizophrenia 1 homolog,Nuclear distribution protein nudE-like 1	protein-containing complex binding binding molecular adaptor activity identical protein binding protein binding cytoskeletal protein binding kinesin binding tubulin binding alpha-tubulin binding microtubule binding peptidase activity catalytic activity, acting on a protein oligopeptidase activity hydrolase activity protein-containing complex binding binding molecular adaptor activity identical protein binding protein binding cytoskeletal protein binding kinesin binding tubulin binding alpha-tubulin binding microtubule binding peptidase activity catalytic activity, acting on a protein oligopeptidase activity hydrolase activity catalytic activity endopeptidase activity beta-tubulin binding	regulation of protein binding regulation of molecular function negative regulation of protein binding negative regulation of binding regulation of binding biological regulation negative regulation of molecular function protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process cellular response to stimulus regulation of protein binding regulation of molecular function negative regulation of protein binding negative regulation of binding regulation of binding biological regulation negative regulation of molecular function protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway cell communication signal transduction Wnt signaling pathway regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of cell adhesion positive regulation of biological process cell-substrate adhesion positive regulation of cell-matrix adhesion cell adhesion cell-matrix adhesion positive regulation of cell-substrate adhesion regulation of cell-matrix adhesion positive regulation of cellular process axon extension multicellular organismal process positive regulation of nervous system development regulation of growth axonogenesis regulation of cellular component size developmental growth cell projection organization regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development positive regulation of developmental process multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development positive regulation of cell projection organization regulation of biological quality positive regulation of developmental growth system development developmental process regulation of cell projection organization positive regulation of cell development nervous system development developmental growth involved in morphogenesis generation of neurons positive regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cellular developmental process regulation of developmental process plasma membrane bounded cell projection morphogenesis cell development cell growth cell morphogenesis regulation of axon extension cellular component organization regulation of nervous system development neurogenesis regulation of extent of cell growth positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process positive regulation of axon extension cellular component organization or biogenesis positive regulation of axonogenesis regulation of anatomical structure morphogenesis regulation of cell size neuron projection extension regulation of multicellular organismal development regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth growth positive regulation of cell growth axon development regulation of cell growth cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis positive regulation of growth neuron development regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size cerebral cortex cell migration head development forebrain development animal organ development brain development cerebral cortex radially oriented cell migration pallium development cerebral cortex development telencephalon cell migration central nervous system development forebrain cell migration cell migration telencephalon development cell motility mitochondrial calcium ion homeostasis inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis positive regulation of neuron projection development response to electrical stimulus response to abiotic stimulus organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process developmental maturation synapse maturation regulation of synapse organization regulation of synapse maturation cell junction organization regulation of synapse structure or activity synapse organization regulation of dendritic spine development dendrite development dendritic spine development detection of external stimulus system process detection of stimulus involved in sensory perception of pain nervous system process response to external stimulus sensory perception of temperature stimulus sensory perception of pain detection of temperature stimulus involved in sensory perception response to temperature stimulus detection of abiotic stimulus detection of stimulus sensory perception detection of temperature stimulus detection of stimulus involved in sensory perception detection of temperature stimulus involved in sensory perception of pain positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction positive regulation of response to stimulus positive regulation of Wnt signaling pathway regulation of signaling regulation of Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling cell proliferation in forebrain cell population proliferation neural precursor cell proliferation TOR signaling intracellular signal transduction postsynapse organization regulation of postsynapse organization neuron cellular homeostasis protein localization to microtubule cytoskeleton protein localization to microtubule organizing center protein localization to cytoskeleton protein localization to organelle protein localization to centrosome positive regulation of protein metabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process positive regulation of macromolecule metabolic process regulation of protein metabolic process regulation of macromolecule metabolic process regulation of catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of metabolic process pyramidal neuron development glial cell migration central nervous system neuron development telencephalon glial cell migration central nervous system neuron differentiation gliogenesis radial glia-guided pyramidal neuron migration pyramidal neuron migration to cerebral cortex neuron migration forebrain generation of neurons forebrain neuron development cerebral cortex radial glia-guided migration forebrain neuron differentiation pyramidal neuron differentiation organelle assembly plasma membrane bounded cell projection assembly cellular component biogenesis organelle organization cellular component assembly cilium assembly cilium organization cell projection assembly non-motile cilium assembly microtubule cytoskeleton organization microtubule-based process cytoskeleton organization trans-synaptic signaling modulation of chemical synaptic transmission synaptic transmission, glutamatergic cell-cell signaling regulation of synaptic transmission, glutamatergic chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling neuroblast proliferation positive regulation of cell population proliferation regulation of neuroblast proliferation regulation of neural precursor cell proliferation positive regulation of neural precursor cell proliferation regulation of cell population proliferation positive regulation of neuroblast proliferation positive regulation of neuron projection regeneration regulation of cellular response to stress regeneration neuron projection regeneration response to wounding positive regulation of response to wounding regulation of axon regeneration regulation of neuron projection regeneration regulation of response to external stimulus response to axon injury regulation of response to wounding positive regulation of response to external stimulus cellular response to stress axon regeneration response to stress regulation of response to stress positive regulation of axon regeneration centrosome localization microtubule organizing center localization cell cycle chromosome segregation cell cycle process regulation of localization establishment of protein localization nitrogen compound transport regulation of protein localization transport establishment of localization in cell regulation of intracellular transport regulation of transport organic substance transport regulation of establishment of protein localization intracellular transport regulation of protein transport establishment of localization protein transport regulation of cellular localization regulation of intracellular protein transport intracellular protein transport membrane organization cellular component disassembly nuclear membrane disassembly membrane disassembly nuclear membrane organization nucleus organization nuclear envelope organization endomembrane system organization inner cell mass cell proliferation chordate embryonic development embryo development in utero embryonic development embryo development ending in birth or egg hatching blastocyst growth blastocyst development establishment of organelle localization spindle localization establishment or maintenance of cell polarity mitotic cell cycle establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation organelle localization microtubule cytoskeleton organization involved in mitosis establishment of cell polarity mitotic cell cycle process establishment of mitotic spindle orientation protein polymerization protein-containing complex organization microtubule polymerization microtubule polymerization or depolymerization microtubule nucleation protein-containing complex assembly supramolecular fiber organization ruffle organization ruffle assembly positive regulation of cellular component biogenesis regulation of cell projection assembly regulation of cellular component biogenesis positive regulation of ruffle assembly regulation of plasma membrane bounded cell projection assembly regulation of ruffle assembly positive regulation of plasma membrane bounded cell projection assembly vesicle cytoskeletal trafficking vesicle localization organelle transport along microtubule establishment of vesicle localization vesicle transport along microtubule microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement lysosome localization vacuolar localization central nervous system neuron axonogenesis chromosome localization establishment of chromosome localization cellular response to nitrogen compound response to organic substance response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus response to hormone cellular response to organic substance enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus response to endogenous stimulus response to organonitrogen compound response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical response to insulin cellular response to insulin stimulus retrograde axonal transport axonal transport axo-dendritic transport mitotic nuclear division microtubule organizing center organization centrosome separation organelle fission mitotic centrosome separation nuclear division centrosome cycle intermediate filament-based process neurofilament cytoskeleton organization intermediate filament cytoskeleton organization	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex kinesin complex microtubule cytoskeleton non-membrane-bounded organelle synapse intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex kinesin complex microtubule cytoskeleton non-membrane-bounded organelle synapse cell junction glutamatergic synapse perinuclear region of cytoplasm axon cell projection neuron projection plasma membrane bounded cell projection cell body intermediate filament cytoskeleton membrane-bounded organelle transport vesicle intracellular vesicle intracellular membrane-bounded organelle endomembrane system presynapse cytoplasmic vesicle synaptic vesicle secretory vesicle vesicle exocytic vesicle cilium ciliary basal body microtubule organizing center polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex mitochondrion growth cone distal axon central region of growth cone site of polarized growth centrosome GABA-ergic synapse postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization asymmetric synapse ciliary base catalytic complex dynein complex organelle envelope nuclear envelope nucleus cell leading edge spindle neuron projection cytoplasm axon cytoplasm cytoplasmic region plasma membrane bounded cell projection cytoplasm somatodendritic compartment neuronal cell body axon hillock chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region condensed chromosome neurofilament cytoskeleton