Annotations: 5XGF

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00392	e5xgfA2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF00392	ECOD (1.6)
A	PF07840	e5xgfA1	A: alpha bundles	X: Fatty acid responsive transcription factor FadR, C-terminal domain (From Topology)	H: Fatty acid responsive transcription factor FadR, C-terminal domain (From Topology)	T: Fatty acid responsive transcription factor FadR, C-terminal domain	F: PF07840	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07840	FadR C-terminal domain (FadR_C)	FadR C-terminal domain	-	Family
A	PF00392	Bacterial regulatory proteins, gntR family (GntR)	Bacterial regulatory proteins, gntR family	This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerisation domain. The GntR-like proteins include the following sub-fam ...	This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerisation domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR [1-2][4][5]. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships [3]. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor [5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Fatty acid metabolism regulator protein	DNA binding binding organic cyclic compound binding nucleic acid binding amide binding adenyl ribonucleotide binding fatty-acyl-CoA binding nucleotide binding acyl-CoA binding purine ribonucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding DNA binding binding organic cyclic compound binding nucleic acid binding amide binding adenyl ribonucleotide binding fatty-acyl-CoA binding nucleotide binding acyl-CoA binding purine ribonucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding lipid binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding fatty acid derivative binding small molecule binding sulfur compound binding transcription regulator activity DNA-binding transcription factor activity	fatty acid metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process organic substance metabolic process cellular lipid metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process regulation of cellular process fatty acid metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process organic substance metabolic process cellular lipid metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process regulation of cellular process regulation of lipid metabolic process regulation of primary metabolic process cellular ketone metabolic process regulation of small molecule metabolic process regulation of biological process regulation of cellular ketone metabolic process biological regulation regulation of cellular metabolic process regulation of fatty acid metabolic process regulation of metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR028374	FadR, C-terminal domain	Domain
A	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A	IPR008920	Transcription regulator FadR/GntR, C-terminal	Homologous Superfamily
A	IPR000524	Transcription regulator HTH, GntR	Domain
A	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A	IPR014178	Fatty acid response transcription factor FadR	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.