Annotations: 5XE3

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	PF02452	e5xe3C1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF02452	ECOD (1.6)
B [auth D]	PF02452	e5xe3D1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF02452	ECOD (1.6)
D [auth A]	PF02452	e5xe3A1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF02452	ECOD (1.6)
E [auth B]	PF02452	e5xe3B1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF02452	ECOD (1.6)
F [auth E]	F_UNCLASSIFIED	e5xe3E1	A: alpha arrays	X: HTH	H: HTH	T: Ribbon-helix-helix	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C], B [auth D], D [auth A], E [auth B]	PF02452	PemK-like, MazF-like toxin of type II toxin-antitoxin system (PemK_toxin)	PemK-like, MazF-like toxin of type II toxin-antitoxin system	PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of ...	PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth D], D [auth A], E [auth B]	Endoribonuclease MazF4	DNA binding binding organic cyclic compound binding nucleic acid binding endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity	catabolic process RNA metabolic process primary metabolic process rRNA catabolic process nucleic acid metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process nucleic acid catabolic process metabolic process macromolecule metabolic process catabolic process RNA metabolic process primary metabolic process rRNA catabolic process nucleic acid metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process nucleic acid catabolic process metabolic process macromolecule metabolic process rRNA metabolic process organic substance catabolic process RNA catabolic process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process organic substance biosynthetic process negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process mRNA catabolic process regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process mRNA metabolic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process cellular process regulation of metabolic process negative regulation of ATP-dependent activity regulation of molecular function regulation of ATP-dependent activity regulation of isomerase activity regulation of catalytic activity negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity regulation of DNA topoisomerase (ATP-hydrolyzing) activity negative regulation of molecular function negative regulation of catalytic activity	-
C [auth F], F [auth E]	Probable antitoxin MazE4	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], B [auth D], D [auth A], E [auth B]	IPR011067	Plasmid maintenance toxin/Cell growth inhibitor	Homologous Superfamily
A [auth C], B [auth D], D [auth A], E [auth B]	IPR003477	mRNA interferase PemK-like	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.