Annotations: 5X6C

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e5x6cA1	A: a+b two layers	X: Alpha-beta plaits	H: O-phosphoseryl-tRNA synthetase C-terminal domain (From Topology)	T: O-phosphoseryl-tRNA synthetase C-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF18006	e5x6cA3	A: a+b two layers	X: SSHS domain	H: SSHS domain in O-phosphoseryl-tRNA synthetase (From Topology)	T: SSHS domain in O-phosphoseryl-tRNA synthetase	F: PF18006	ECOD (1.6)
A	PF01409	e5x6cA2	A: a+b three layers	X: Class II aaRS and biotin synthetases (From Topology)	H: Class II aaRS and biotin synthetases (From Topology)	T: Class II aaRS and biotin synthetases	F: PF01409	ECOD (1.6)
B	F_UNCLASSIFIED	e5x6cB3	A: a+b two layers	X: Alpha-beta plaits	H: O-phosphoseryl-tRNA synthetase C-terminal domain (From Topology)	T: O-phosphoseryl-tRNA synthetase C-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF18006	e5x6cB1	A: a+b two layers	X: SSHS domain	H: SSHS domain in O-phosphoseryl-tRNA synthetase (From Topology)	T: SSHS domain in O-phosphoseryl-tRNA synthetase	F: PF18006	ECOD (1.6)
B	PF01409	e5x6cB2	A: a+b three layers	X: Class II aaRS and biotin synthetases (From Topology)	H: Class II aaRS and biotin synthetases (From Topology)	T: Class II aaRS and biotin synthetases	F: PF01409	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01409	tRNA synthetases class II core domain (F) (tRNA-synt_2d)	tRNA synthetases class II core domain (F)	Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only phenylalanyl-tRNA synthetases. This is the core catalytic domain.	Domain
A, B	PF18006	O-phosphoseryl-tRNA synthetase C-terminal domain (SepRS_C)	O-phosphoseryl-tRNA synthetase C-terminal domain	The SSHS domain is mainly found in Archaea. The domain makes up part of the anticodon binding domain at the C-terminal of O-phosphoserine--tRNA(Cys) ligase [1,2].	Domain
C [auth E], D [auth F]	PF09873	Uncharacterized protein conserved in archaea (DUF2100) (DUF2100)	Uncharacterized protein conserved in archaea (DUF2100)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	O-phosphoserine--tRNA(Cys) ligase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ligase activity, forming carbon-oxygen bonds aminoacyl-tRNA ligase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid phenylalanine-tRNA ligase activity catalytic activity, acting on a tRNA catalytic activity ligase activity phosphoserine-tRNA(Cys) ligase activity RNA binding tRNA binding nucleic acid binding	amino acid activation tRNA aminoacylation cellular biosynthetic process organonitrogen compound biosynthetic process RNA metabolic process amino acid metabolic process nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process protein metabolic process organonitrogen compound metabolic process cellular metabolic process primary metabolic process translation amino acid activation tRNA aminoacylation cellular biosynthetic process organonitrogen compound biosynthetic process RNA metabolic process amino acid metabolic process nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process protein metabolic process organonitrogen compound metabolic process cellular metabolic process primary metabolic process translation gene expression tRNA aminoacylation for protein translation macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process organic cyclic compound metabolic process biosynthetic process metabolic process cellular process macromolecule metabolic process phenylalanyl-tRNA aminoacylation	intracellular anatomical structure cytoplasm cellular anatomical entity
C [auth E], D [auth F]	Uncharacterized protein MJ1481	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR006195	Aminoacyl-tRNA synthetase, class II	Domain
A, B	IPR005246	O-phosphoseryl-tRNA(Cys) ligase	Family
A, B	IPR045864	Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)	Homologous Superfamily
A, B	IPR002319	Phenylalanyl-tRNA synthetase	Domain
A, B	IPR041590	O-phosphoserine--tRNA(Cys) ligase, C-terminal domain	Domain
C [auth E], D [auth F]	IPR016736	Uncharacterised protein MJ1481, archaea	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.