5TQC

Crystal structure of transport factor karyopherin-beta 2 in complex with the PY-NLS of ribosomal protein L4 (RpL4)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5tqca_	All alpha proteins	alpha-alpha superhelix	ARM repeat	Armadillo repeat	automated matches	Human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ARM repeat-like	8038551	3000116	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13513	e5tqcA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF13513	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF14374	60S ribosomal protein L4 C-terminal domain (Ribos_L4_asso_C)	60S ribosomal protein L4 C-terminal domain	This family is found at the very C-terminal of 60 ribosomal L4 proteins.	Domain
A	PF03810	Importin-beta N-terminal domain (IBN_N)	Importin-beta N-terminal domain	-	Repeat
A	PF13513	HEAT-like repeat (HEAT_EZ)	HEAT-like repeat	-	Repeat
A	PF02985	HEAT repeat (HEAT)	HEAT repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	60S ribosomal protein L4-like protein	RNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process	protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular organelle ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol large ribosomal subunit protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular organelle ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol large ribosomal subunit non-membrane-bounded organelle
A	Transportin-1,Transportin-1	small GTPase binding protein binding binding enzyme binding GTPase binding nuclear import signal receptor activity nucleocytoplasmic carrier activity molecular carrier activity RNA binding organic cyclic compound binding nucleic acid binding nuclear localization sequence binding signal sequence binding peptide binding	protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus cellular process intracellular protein transport	membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol intracellular organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR025755	Large ribosomal subunit protein uL4, C-terminal domain	Domain
B	IPR002136	Large ribosomal subunit protein uL4	Family
B	IPR013000	Large ribosomal subunit protein uL4, eukaryotic/archaeal, conserved site	Conserved Site
B	IPR045240	Large ribosomal subunit protein uL4, eukaryotic and archaeal type	Family
B	IPR023574	Large ribosomal subunit protein uL4 domain superfamily	Homologous Superfamily
A	IPR040122	Importin beta family	Family
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR001494	Importin-beta, N-terminal domain	Domain
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR000357	HEAT repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q92973	malignant pancreatic neoplasm non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm acne pilocytic astrocytoma atopic eczema psoriasis chronic obstructive pulmonary disease subependymal giant cell astrocytoma esophageal adenocarcinoma hepatocellular carcinoma large cell medulloblastoma malignant ependymoma medulloblastoma malignant pancreatic neoplasm non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm acne pilocytic astrocytoma atopic eczema psoriasis chronic obstructive pulmonary disease subependymal giant cell astrocytoma esophageal adenocarcinoma hepatocellular carcinoma large cell medulloblastoma malignant ependymoma medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Alzheimer disease plasma cell myeloma atrial fibrillation rheumatoid arthritis Crohn disease tuberculosis exocrine pancreatic carcinoma invasive ductal breast carcinoma lung cancer malignant glioma myopathy osteosarcoma pancreatic intraductal papillary-mucinous carcinoma Pick disease astrocytic tumor primitive neuroectodermal tumor atypical teratoid rhabdoid tumor Sjogren syndrome dermatomyositis ulcerative colitis glioblastoma juvenile dermatomyositis lymphoplasmacytic lymphoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.