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Crystal structure of Dot1L in complex with adenosine and inhibitor CPD1 [N6-(2,6-dichlorophenyl)-N6-(pent-2-yn-1-yl)quinoline-4,6-diamine] External Resource: Annotation Domain Annotation: SCOP2 Classification SCOP2 Database Homepage Chains Type Family Name Domain Identifier Family Identifier Provenance Source (Version) A SCOP2B Superfamily S-adenosyl-L-methionine-dependent methyltransferases 8033656 3000118 SCOP2B (2022-06-29) B SCOP2B Superfamily S-adenosyl-L-methionine-dependent methyltransferases 8033656 3000118 SCOP2B (2022-06-29)
Chains Family Name Domain Identifier Architecture Possible Homology Homology Topology Family Provenance Source (Version) A PF08123 e5mvsA1 A: a/b three-layered sandwiches X: Rossmann-like H: Rossmann-related T: S-adenosyl-L-methionine-dependent methyltransferases F: PF08123 ECOD (1.6) B PF08123 e5mvsB1 A: a/b three-layered sandwiches X: Rossmann-like H: Rossmann-related T: S-adenosyl-L-methionine-dependent methyltransferases F: PF08123 ECOD (1.6)
Chains Accession Name Description Comments Source PF08123 Histone methylation protein DOT1 (DOT1) Histone methylation protein DOT1 The DOT1 domain regulates gene expression by methylating histone H3 [1]. H3 methylation by DOT1 has been shown to be required for the DNA damage checkpoint in yeast [2]. Domain
Chains Polymer Molecular Function Biological Process Cellular Component Histone-lysine N-methyltransferase, H3 lysine-79 specific
Chains Drug Target   Associated Disease Pharos :  Q8TEK3