5LHZ

PB3 Domain of Human PLK4 in Complex with Coiled-Coil Domain of STIL

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5lhza_	Alpha and beta proteins (a+b)	Polo-box domain	Polo-box domain	Swapped Polo-box domain	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d5lhzb_	Alpha and beta proteins (a+b)	Polo-box domain	Polo-box domain	Swapped Polo-box domain	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d5lhzc_	Alpha and beta proteins (a+b)	Polo-box domain	Polo-box domain	Swapped Polo-box domain	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Polo-box domain	8086376	3000394	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Polo-box domain	8086376	3000394	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Polo-box domain	8086376	3000394	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00659	e5lhzA1	A: a+b two layers	X: RIP/Polo-box domain	H: Polo-box domain (From Topology)	T: Polo-box domain	F: PF00659	ECOD (1.6)
B	PF00659	e5lhzB1	A: a+b two layers	X: RIP/Polo-box domain	H: Polo-box domain (From Topology)	T: Polo-box domain	F: PF00659	ECOD (1.6)
C	PF00659	e5lhzC1	A: a+b two layers	X: RIP/Polo-box domain	H: Polo-box domain (From Topology)	T: Polo-box domain	F: PF00659	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.1120.30	Alpha Beta	2-Layer Sandwich	Arylsulfatase, C-terminal domain	POLO box domain	CATH (4.3.0)
B	3.30.1120.30	Alpha Beta	2-Layer Sandwich	Arylsulfatase, C-terminal domain	POLO box domain	CATH (4.3.0)
C	3.30.1120.30	Alpha Beta	2-Layer Sandwich	Arylsulfatase, C-terminal domain	POLO box domain	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
D, E, F	SCL-interrupting locus protein	identical protein binding protein binding binding	cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation smoothened signaling pathway cell communication cellular process signal transduction regulation of cellular component organization non-membrane-bounded organelle assembly microtubule cytoskeleton organization cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation smoothened signaling pathway cell communication cellular process signal transduction regulation of cellular component organization non-membrane-bounded organelle assembly microtubule cytoskeleton organization cellular component organization cellular component biogenesis centrosome duplication cellular component assembly centrosome cycle cell cycle cellular component organization or biogenesis regulation of cell cycle regulation of centriole replication cell cycle process centriole replication centriole assembly microtubule organizing center organization organelle assembly regulation of centrosome cycle regulation of cell cycle process regulation of microtubule-based process regulation of cellular component biogenesis regulation of organelle organization organelle organization regulation of centrosome duplication regulation of organelle assembly microtubule-based process cytoskeleton organization protein localization to microtubule cytoskeleton protein localization cellular localization protein localization to microtubule organizing center localization protein localization to cytoskeleton protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to centrosome negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death positive regulation of organelle organization regulation of cytoskeleton organization positive regulation of cellular component organization positive regulation of biological process positive regulation of spindle assembly positive regulation of cell cycle process chromosome segregation positive regulation of cellular process spindle organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization regulation of spindle organization spindle assembly positive regulation of cell cycle regulation of spindle assembly regulation of microtubule cytoskeleton organization positive regulation of organelle assembly developmental process multicellular organismal process epithelium development floor plate development neural tube development tube development chordate embryonic development nervous system development embryo development tissue development multicellular organism development embryo development ending in birth or egg hatching anatomical structure development system development regulation of cell cycle phase transition cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of mitotic cell cycle positive regulation of G1/S transition of mitotic cell cycle regulation of mitotic cell cycle phase transition positive regulation of cell cycle G1/S phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle positive regulation of cell cycle phase transition G1/S transition of mitotic cell cycle mitotic cell cycle phase transition in utero embryonic development embryonic epithelial tube formation tube formation epithelial tube formation tube morphogenesis primary neural tube formation epithelial tube morphogenesis morphogenesis of embryonic epithelium embryonic morphogenesis morphogenesis of an epithelium anatomical structure morphogenesis tissue morphogenesis neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure regulation of mitotic spindle organization microtubule cytoskeleton organization involved in mitosis mitotic spindle organization determination of bilateral symmetry pattern specification process determination of left/right symmetry left/right pattern formation regionalization specification of symmetry head development forebrain development animal organ development brain development central nervous system development embryonic axis specification embryonic pattern specification axis specification embryonic organ development notochord development positive regulation of centriole replication multicellular organism growth developmental growth growth heart morphogenesis embryonic heart tube development embryonic heart tube morphogenesis heart looping animal organ morphogenesis embryonic organ morphogenesis heart development determination of heart left/right asymmetry circulatory system development	cell periphery cell cortex intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle centrosome microtubule organizing center cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle centriole cell periphery cell cortex intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle centrosome microtubule organizing center cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle centriole cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex procentriole replication complex
A, B, C	Serine/threonine-protein kinase PLK4	catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity identical protein binding protein binding	developmental process cell differentiation involved in embryonic placenta development multicellular organismal process cellular developmental process placenta development reproductive process chordate embryonic development animal organ development developmental process involved in reproduction embryo development in utero embryonic development trophoblast giant cell differentiation multicellular organism development embryonic placenta development embryo development ending in birth or egg hatching developmental process cell differentiation involved in embryonic placenta development multicellular organismal process cellular developmental process placenta development reproductive process chordate embryonic development animal organ development developmental process involved in reproduction embryo development in utero embryonic development trophoblast giant cell differentiation multicellular organism development embryonic placenta development embryo development ending in birth or egg hatching cell differentiation anatomical structure development cellular process embryonic organ development centriole assembly microtubule organizing center organization organelle assembly non-membrane-bounded organelle assembly microtubule cytoskeleton organization cellular component organization cellular component biogenesis centrosome duplication organelle organization cellular component assembly centrosome cycle microtubule-based process cell cycle cellular component organization or biogenesis cytoskeleton organization centriole replication cell cycle process plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cilium assembly cilium organization cell projection assembly epithelial cell differentiation epithelium development tissue development multi-ciliated epithelial cell differentiation de novo centriole assembly involved in multi-ciliated epithelial cell differentiation de novo centriole assembly protein phosphorylation organonitrogen compound metabolic process phosphorylation cellular metabolic process primary metabolic process organic substance metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process mitotic cell cycle mitotic spindle organization mitotic cell cycle process microtubule cytoskeleton organization involved in mitosis spindle organization positive regulation of organelle organization regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization positive regulation of biological process positive regulation of cell cycle process regulation of cell cycle positive regulation of cellular process regulation of centriole replication regulation of biological process regulation of cell cycle process positive regulation of cellular component biogenesis regulation of centrosome cycle positive regulation of cytoskeleton organization biological regulation regulation of microtubule-based process regulation of cellular component biogenesis regulation of organelle organization positive regulation of cell cycle regulation of organelle assembly regulation of centrosome duplication positive regulation of centriole replication positive regulation of organelle assembly	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cytoskeleton spindle spindle pole microtubule cytoskeleton centrosome microtubule organizing center centriole cytoplasm cytosol XY body sex chromosome chromosome cell division site cell periphery cleavage furrow membrane plasma membrane plasma membrane region chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome protein-containing complex procentriole replication complex procentriole deuterosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
D, E, F	IPR026123	SCL-interrupting locus protein	Family
A, B, C	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B, C	IPR008266	Tyrosine-protein kinase, active site	Active Site
A, B, C	IPR000719	Protein kinase domain	Domain
A, B, C	IPR033696	Plk4, C-terminal polo-box domain	Domain
A, B, C	IPR000959	POLO box domain	Domain
A, B, C	IPR033698	Plk4, second cryptic polo-box domain	Domain
A, B, C	IPR046437	Serine/threonine-protein kinase, first cryptic polo-box domain superfamily	Homologous Superfamily
A, B, C	IPR047108	Plk4-like, second cryptic polo-box domain superfamily	Homologous Superfamily
A, B, C	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B, C	IPR033699	Plk4, first cryptic polo-box domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
D, E, F	Pharos: Q15468	microcephaly 7, primary, autosomal recessive microcephaly intellectual disability autosomal recessive primary microcephaly malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor acute lymphoblastic leukemia atopic eczema breast cancer ductal breast carcinoma in situ lung adenocarcinoma malignant glioma medulloblastoma microcephaly 7, primary, autosomal recessive microcephaly intellectual disability autosomal recessive primary microcephaly malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor acute lymphoblastic leukemia atopic eczema breast cancer ductal breast carcinoma in situ lung adenocarcinoma malignant glioma medulloblastoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma psoriasis acute T cell leukemia atypical teratoid rhabdoid tumor cancer endogenous depression invasive ductal breast carcinoma lung cancer malignant mesothelioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm adrenal cortex carcinoma Crohn disease glioblastoma large cell medulloblastoma malignant ependymoma
A, B, C	Pharos: O00444	Seckel syndrome microcephaly Eye Diseases, Hereditary microcephaly and chorioretinopathy 2 microlissencephaly ovarian cancer primitive neuroectodermal tumor acute myeloid leukemia breast cancer invasive ductal breast carcinoma malignant colon neoplasm malignant mesothelioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm renal cell carcinoma Seckel syndrome microcephaly Eye Diseases, Hereditary microcephaly and chorioretinopathy 2 microlissencephaly ovarian cancer primitive neuroectodermal tumor acute myeloid leukemia breast cancer invasive ductal breast carcinoma malignant colon neoplasm malignant mesothelioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm renal cell carcinoma thrombocytopenia due to immune destruction adrenal cortex carcinoma ductal breast carcinoma in situ glioblastoma large cell medulloblastoma malignant ependymoma medulloblastoma osteosarcoma atypical teratoid rhabdoid tumor intellectual disability lung cancer malignant glioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.