5KS8
Crystal structure of two-subunit pyruvate carboxylase from Methylobacillus flagellatus
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF02786 | e5ks8A1 | A: a+b complex topology | X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology) | H: Protein kinase/SAICAR synthase/ATP-grasp | T: ATP-grasp | F: PF02786 | ECOD (1.6) |
A | PF02785 | e5ks8A3 | A: a+b complex topology | X: alpha/beta-Hammerhead/Barrel-sandwich hybrid | H: alpha/beta-Hammerhead/Barrel-sandwich hybrid | T: CO dehydrogenase molybdoprotein N-domain-like | F: PF02785 | ECOD (1.6) |
A | PF00289 | e5ks8A2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: PreATP-grasp domain | F: PF00289 | ECOD (1.6) |
B | PF02786 | e5ks8B1 | A: a+b complex topology | X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology) | H: Protein kinase/SAICAR synthase/ATP-grasp | T: ATP-grasp | F: PF02786 | ECOD (1.6) |
B | PF02785 | e5ks8B3 | A: a+b complex topology | X: alpha/beta-Hammerhead/Barrel-sandwich hybrid | H: alpha/beta-Hammerhead/Barrel-sandwich hybrid | T: CO dehydrogenase molybdoprotein N-domain-like | F: PF02785 | ECOD (1.6) |
B | PF00289 | e5ks8B2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: PreATP-grasp domain | F: PF00289 | ECOD (1.6) |
C | PF02436 | e5ks8C2 | A: alpha arrays | X: RuvA-C | H: post-HMGL domain-like (From Topology) | T: post-HMGL domain-like | F: PF02436 | ECOD (1.6) |
C | F_UNCLASSIFIED | e5ks8C4 | A: a+b two layers | X: Methylcrotonyl-CoA carboxylase alpha-subunit BT domain-related (From Homology) | H: Methylcrotonyl-CoA carboxylase alpha-subunit BT domain-related | T: a+b domain in pyruvate carboxylase | F: F_UNCLASSIFIED | ECOD (1.6) |
C | PF00364 | e5ks8C3 | A: a+b complex topology | X: alpha/beta-Hammerhead/Barrel-sandwich hybrid | H: alpha/beta-Hammerhead/Barrel-sandwich hybrid | T: Single hybrid motif | F: PF00364 | ECOD (1.6) |
C | PF00682 | e5ks8C1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: PF00682 | ECOD (1.6) |
D | F_UNCLASSIFIED | e5ks8D4 | A: alpha arrays | X: RuvA-C | H: post-HMGL domain-like (From Topology) | T: post-HMGL domain-like | F: F_UNCLASSIFIED | ECOD (1.6) |
D | PF02436 | e5ks8D2 | A: alpha arrays | X: RuvA-C | H: post-HMGL domain-like (From Topology) | T: post-HMGL domain-like | F: PF02436 | ECOD (1.6) |
D | F_UNCLASSIFIED | e5ks8D5 | A: a+b two layers | X: Methylcrotonyl-CoA carboxylase alpha-subunit BT domain-related (From Homology) | H: Methylcrotonyl-CoA carboxylase alpha-subunit BT domain-related | T: a+b domain in pyruvate carboxylase | F: F_UNCLASSIFIED | ECOD (1.6) |
D | PF00364 | e5ks8D3 | A: a+b complex topology | X: alpha/beta-Hammerhead/Barrel-sandwich hybrid | H: alpha/beta-Hammerhead/Barrel-sandwich hybrid | T: Single hybrid motif | F: PF00364 | ECOD (1.6) |
D | PF00682 | e5ks8D1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: PF00682 | ECOD (1.6) |
F | F_UNCLASSIFIED | e5ks8F2 | A: a+b two layers | X: Methylcrotonyl-CoA carboxylase alpha-subunit BT domain-related (From Homology) | H: Methylcrotonyl-CoA carboxylase alpha-subunit BT domain-related | T: a+b domain in pyruvate carboxylase | F: F_UNCLASSIFIED | ECOD (1.6) |
F | PF00364 | e5ks8F3 | A: a+b complex topology | X: alpha/beta-Hammerhead/Barrel-sandwich hybrid | H: alpha/beta-Hammerhead/Barrel-sandwich hybrid | T: Single hybrid motif | F: PF00364 | ECOD (1.6) |
F | PF00682,PF02436 | e5ks8F1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: PF00682,PF02436 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.30.470.20 | Alpha Beta | 2-Layer Sandwich | D-amino Acid Aminotransferase | Chain A, domain 1 | CATH (4.3.0) |
B | 3.30.470.20 | Alpha Beta | 2-Layer Sandwich | D-amino Acid Aminotransferase | Chain A, domain 1 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF02786 | Carbamoyl-phosphate synthase L chain, ATP binding domain (CPSase_L_D2) | Carbamoyl-phosphate synthase L chain, ATP binding domain | Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines [2]. The c ... | Domain | |
PF00289 | Biotin carboxylase, N-terminal domain (Biotin_carb_N) | Biotin carboxylase, N-terminal domain | This domain is structurally related to the PreATP-grasp domain. The family contains the N-terminus of biotin carboxylase enzymes [1,3], and propionyl-CoA carboxylase A chain [2]. | Domain | |
PF02785 | Biotin carboxylase C-terminal domain (Biotin_carb_C) | Biotin carboxylase C-terminal domain | Biotin carboxylase is a component of the acetyl-CoA carboxylase multi-component enzyme which catalyses the first committed step in fatty acid synthesis in animals, plants and bacteria. Most of the active site residues reported in reference [1] are i ... | Domain | |
PF00682 | HMGL-like (HMGL-like) | HMGL-like | This family contains a diverse set of enzymes. These include various aldolases and a region of pyruvate carboxylase. | Domain | |
PF00364 | Biotin-requiring enzyme (Biotin_lipoyl) | Biotin-requiring enzyme | This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognise the Glycine cleavage system H proteins. | Domain | |
PF02436 | Conserved carboxylase domain (PYC_OADA) | Conserved carboxylase domain | This domain represents a conserved region in pyruvate carboxylase (PYC), oxaloacetate decarboxylase alpha chain (OADA), and transcarboxylase 5s subunit. The domain is found adjacent to the HMGL-like domain (Pfam:PF00682) and often close to the bio ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR005481 | Biotin carboxylase-like, N-terminal domain | Domain | |
IPR011761 | ATP-grasp fold | Domain | |
IPR011764 | Biotin carboxylation domain | Domain | |
IPR004549 | Acetyl-CoA carboxylase, biotin carboxylase | Family | |
IPR005482 | Biotin carboxylase, C-terminal | Domain | |
IPR005479 | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain | Domain | |
IPR016185 | Pre-ATP-grasp domain superfamily | Homologous Superfamily | |
IPR011054 | Rudiment single hybrid motif | Homologous Superfamily | |
IPR003379 | Carboxylase, conserved domain | Domain | |
IPR013785 | Aldolase-type TIM barrel | Homologous Superfamily | |
IPR005776 | Oxaloacetate decarboxylase, alpha subunit | Family | |
IPR011053 | Single hybrid motif | Homologous Superfamily | |
IPR000891 | Pyruvate carboxyltransferase | Domain | |
IPR001882 | Biotin-binding site | Binding Site | |
IPR000089 | Biotin/lipoyl attachment | Domain |