5JQI

Crystal structure of FimH A62S from E. coli UTI89 bound to FimG N-terminal extension

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth H]	PF00419	e5jqiH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PF00419	ECOD (1.6)
B [auth H]	PF09160	e5jqiH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PF09160	ECOD (1.6)
D [auth B]	PF00419	e5jqiB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PF00419	ECOD (1.6)
D [auth B]	PF09160	e5jqiB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PF09160	ECOD (1.6)
F [auth D]	PF00419	e5jqiD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PF00419	ECOD (1.6)
F [auth D]	PF09160	e5jqiD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PF09160	ECOD (1.6)
H [auth F]	PF00419	e5jqiF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PF00419	ECOD (1.6)
H [auth F]	PF09160	e5jqiF2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PF09160	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth H]	2.60.40.1090	Mainly Beta	Sandwich	Immunoglobulin-like	Fimbrial-type adhesion domain	CATH (4.3.0)
D [auth B]	2.60.40.1090	Mainly Beta	Sandwich	Immunoglobulin-like	Fimbrial-type adhesion domain	CATH (4.3.0)
F [auth D]	2.60.40.1090	Mainly Beta	Sandwich	Immunoglobulin-like	Fimbrial-type adhesion domain	CATH (4.3.0)
H [auth F]	2.60.40.1090	Mainly Beta	Sandwich	Immunoglobulin-like	Fimbrial-type adhesion domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth H], D [auth B], F [auth D], H [auth F]	PF00419	Fimbrial protein (Fimbrial)	Fimbrial protein	-	Domain
B [auth H], D [auth B], F [auth D], H [auth F]	PF09160	FimH, mannose binding (FimH_man-bind)	FimH, mannose binding	Members of this family adopt a secondary structure consisting of a beta sandwich, with nine strands arranged in two sheets in a Greek key topology. They are predominantly found in bacterial mannose-specific adhesins, since they are capable of binding ...	Members of this family adopt a secondary structure consisting of a beta sandwich, with nine strands arranged in two sheets in a Greek key topology. They are predominantly found in bacterial mannose-specific adhesins, since they are capable of binding to D-mannose [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth G], C [auth A], E [auth C], G [auth E]	FimG N-terminal extension	-	cell adhesion cellular process	pilus cell projection cellular anatomical entity
B [auth H], D [auth B], F [auth D], H [auth F]	Type 1 fimbiral adhesin FimH	-	cell adhesion cellular process	pilus cell projection cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth G], C [auth A], E [auth C], G [auth E]	IPR036937	Fimbrial-type adhesion domain superfamily	Homologous Superfamily
A [auth G], C [auth A], E [auth C], G [auth E]	IPR008966	Adhesion domain superfamily	Homologous Superfamily
B [auth H], D [auth B], F [auth D], H [auth F]	IPR000259	Fimbrial-type adhesion domain	Domain
B [auth H], D [auth B], F [auth D], H [auth F]	IPR036937	Fimbrial-type adhesion domain superfamily	Homologous Superfamily
B [auth H], D [auth B], F [auth D], H [auth F]	IPR015243	FimH, mannose-binding domain	Domain
B [auth H], D [auth B], F [auth D], H [auth F]	IPR008966	Adhesion domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.