5JP2

Fcho1 Mu homology domain (Danio Rerio) with bound Eps15 peptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth A]	SCOP2 Family	Muniscin C-terminal domain-like	8044648	4004061	SCOP2 (2022-06-29)
B [auth A]	SCOP2 Superfamily	mu adaptin domain-like	8051822	3000810	SCOP2 (2022-06-29)
D [auth B]	SCOP2B Superfamily	mu adaptin domain-like	8051822	3000810	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth A]	PF10291	e5jp2A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PF10291	ECOD (1.6)
D [auth B]	PF10291	e5jp2B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PF10291	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth A], D [auth B]	PF10291	Muniscin C-terminal mu homology domain (muHD)	Muniscin C-terminal mu homology domain	The muniscins are a family of endocytic adaptors that is conserved from yeast to humans.This C-terminal domain is structurally similar to mu homology domains, and is the region of the muniscin proteins involved in the interactions with the endocytic ...	The muniscins are a family of endocytic adaptors that is conserved from yeast to humans.This C-terminal domain is structurally similar to mu homology domains, and is the region of the muniscin proteins involved in the interactions with the endocytic adaptor-scaffold proteins Ede1-eps15. This interaction influences muniscin localisation. The muniscins provide a combined adaptor-membrane-tubulation activity that is important for regulating endocytosis.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth E], C [auth F]	Epidermal growth factor receptor substrate 15	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding SH3 domain binding protein binding protein domain specific binding cell adhesion molecule binding cadherin binding polyubiquitin modification-dependent protein binding modification-dependent protein binding	localization import into cell transport cellular process endocytosis establishment of localization vesicle-mediated transport receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell viral process localization import into cell transport cellular process endocytosis establishment of localization vesicle-mediated transport receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell viral process symbiont entry into host endocytosis involved in viral entry into host cell receptor-mediated endocytosis transport of virus protein localization establishment of protein localization cellular localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization receptor internalization postsynaptic neurotransmitter receptor internalization biological regulation vesicle-mediated transport in synapse protein-containing complex localization neurotransmitter receptor internalization regulation of postsynaptic membrane neurotransmitter receptor levels postsynaptic endocytosis establishment of localization in cell regulation of biological quality regulation of signaling regulation of biological process signaling regulation of receptor recycling positive regulation of biological process regulation of macromolecule metabolic process receptor recycling positive regulation of metabolic process organic substance metabolic process receptor metabolic process positive regulation of receptor recycling positive regulation of macromolecule metabolic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of signaling intracellular transport endosomal transport clathrin coat assembly cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis vesicle organization organelle organization cell population proliferation regulation of cellular process regulation of cell population proliferation localization within membrane endocytic recycling vesicle-mediated transport to the plasma membrane Golgi to endosome transport post-Golgi vesicle-mediated transport cytosolic transport Golgi vesicle transport	protein-containing complex intracellular anatomical structure plasma membrane protein complex membrane plasma membrane membrane protein complex cellular anatomical entity coated membrane endomembrane system clathrin coat membrane coat cell periphery clathrin-coated pit cytoplasm protein-containing complex intracellular anatomical structure plasma membrane protein complex membrane plasma membrane membrane protein complex cellular anatomical entity coated membrane endomembrane system clathrin coat membrane coat cell periphery clathrin-coated pit cytoplasm clathrin coat of coated pit apical part of cell plasma membrane region apical plasma membrane basal part of cell basal plasma membrane cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle inclusion body aggresome synapse cell junction glutamatergic synapse endosome membrane early endosome endosome intracellular vesicle early endosome membrane cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane vesicle organelle membrane postsynapse
B [auth A], D [auth B]	F-BAR domain only protein 1	cation binding ion binding binding metal ion binding small molecule binding	localization import into cell transport clathrin-dependent endocytosis cellular process receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport clathrin coat assembly cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization localization import into cell transport clathrin-dependent endocytosis cellular process receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport clathrin coat assembly cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis	cell periphery plasma membrane membrane cellular anatomical entity clathrin-coated pit endomembrane system membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle clathrin-coated vesicle cell periphery plasma membrane membrane cellular anatomical entity clathrin-coated pit endomembrane system membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle clathrin-coated vesicle coated vesicle cytoplasm vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth E], C [auth F]	IPR000261	EH domain	Domain
A [auth E], C [auth F]	IPR002048	EF-hand domain	Domain
A [auth E], C [auth F]	IPR011992	EF-hand domain pair	Homologous Superfamily
A [auth E], C [auth F]	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A [auth E], C [auth F]	IPR003903	Ubiquitin interacting motif	Conserved Site
B [auth A], D [auth B]	IPR018808	Muniscin, C-terminal	Domain
B [auth A], D [auth B]	IPR028565	Mu homology domain	Domain
B [auth A], D [auth B]	IPR027267	AH/BAR domain superfamily	Homologous Superfamily
B [auth A], D [auth B]	IPR042735	FCHo1, F-BAR domain	Domain
B [auth A], D [auth B]	IPR001060	FCH domain	Domain
B [auth A], D [auth B]	IPR031160	F-BAR domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth E], C [auth F]	Pharos: P42566	primitive neuroectodermal tumor astrocytic tumor dermatomyositis large cell medulloblastoma malignant ependymoma medulloblastoma osteosarcoma pilocytic astrocytoma atypical teratoid rhabdoid tumor glioblastoma lung cancer malignant glioma non-small cell lung carcinoma ovarian cancer pituitary cancer primitive neuroectodermal tumor astrocytic tumor dermatomyositis large cell medulloblastoma malignant ependymoma medulloblastoma osteosarcoma pilocytic astrocytoma atypical teratoid rhabdoid tumor glioblastoma lung cancer malignant glioma non-small cell lung carcinoma ovarian cancer pituitary cancer cancer invasive ductal breast carcinoma lymphoplasmacytic lymphoma malignant mesothelioma oligodendroglioma Pick disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.