5IXM

The LPS Transporter LptDE from Yersinia pestis, core complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	TolB N-terminal domain-like	8053479	3000482	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	TolB N-terminal domain-like	8053479	3000482	SCOP2B (2022-06-29)
F	SCOP2 Family	LptE-like	8045852	4004725	SCOP2 (2022-06-29)
F	SCOP2 Superfamily	TolB N-terminal domain-like	8053479	3000482	SCOP2 (2022-06-29)
H	SCOP2B Superfamily	TolB N-terminal domain-like	8053479	3000482	SCOP2B (2022-06-29)
A	SCOP2 Family	LptD C-terminal domain-like	8045951	4004780	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	LptD-like barrel	8053494	3002195	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	LptD-like barrel	8053494	3002195	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	LptD-like barrel	8053494	3002195	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	LptD-like barrel	8053494	3002195	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	LptE	e5ixmB1	A: a/b three-layered sandwiches	X: TolB, N-terminal domain (From Topology)	H: TolB, N-terminal domain (From Topology)	T: TolB, N-terminal domain	F: LptE	ECOD (1.6)
D	LptE	e5ixmD1	A: a/b three-layered sandwiches	X: TolB, N-terminal domain (From Topology)	H: TolB, N-terminal domain (From Topology)	T: TolB, N-terminal domain	F: LptE	ECOD (1.6)
F	LptE	e5ixmF1	A: a/b three-layered sandwiches	X: TolB, N-terminal domain (From Topology)	H: TolB, N-terminal domain (From Topology)	T: TolB, N-terminal domain	F: LptE	ECOD (1.6)
H	LptE	e5ixmH1	A: a/b three-layered sandwiches	X: TolB, N-terminal domain (From Topology)	H: TolB, N-terminal domain (From Topology)	T: TolB, N-terminal domain	F: LptE	ECOD (1.6)
A	OstA_C	e5ixmA1	A: beta barrels	X: Outer membrane meander beta-barrels	H: LPS-assembly protein LptD (From Topology)	T: LPS-assembly protein LptD	F: OstA_C	ECOD (1.6)
C	OstA_C	e5ixmC1	A: beta barrels	X: Outer membrane meander beta-barrels	H: LPS-assembly protein LptD (From Topology)	T: LPS-assembly protein LptD	F: OstA_C	ECOD (1.6)
E	OstA_C	e5ixmE1	A: beta barrels	X: Outer membrane meander beta-barrels	H: LPS-assembly protein LptD (From Topology)	T: LPS-assembly protein LptD	F: OstA_C	ECOD (1.6)
G	OstA_C	e5ixmG1	A: beta barrels	X: Outer membrane meander beta-barrels	H: LPS-assembly protein LptD (From Topology)	T: LPS-assembly protein LptD	F: OstA_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.160.150	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain	Lipoprotein like domain	CATH (4.3.0)
D	3.30.160.150	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain	Lipoprotein like domain	CATH (4.3.0)
F	3.30.160.150	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain	Lipoprotein like domain	CATH (4.3.0)
H	3.30.160.150	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain	Lipoprotein like domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, D, F, H	PF04390	Lipopolysaccharide-assembly (LptE)	Lipopolysaccharide-assembly	-	Family
A, C, E, G	PF04453	LPS transport system D (LptD)	LPS transport system D	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B, D, F, H	LPS-assembly lipoprotein LptE	binding lipid binding lipopolysaccharide binding carbohydrate derivative binding	membrane organization membrane biogenesis membrane assembly cellular component organization cellular component biogenesis cellular component assembly cellular process cellular component organization or biogenesis cell envelope organization Gram-negative-bacterium-type cell outer membrane assembly external encapsulating structure organization localization transport lipopolysaccharide transport membrane organization membrane biogenesis membrane assembly cellular component organization cellular component biogenesis cellular component assembly cellular process cellular component organization or biogenesis cell envelope organization Gram-negative-bacterium-type cell outer membrane assembly external encapsulating structure organization localization transport lipopolysaccharide transport macromolecule localization organic substance transport lipid localization lipid transport carbohydrate derivative transport establishment of localization	cell periphery cell outer membrane external encapsulating structure membrane cell envelope outer membrane cellular anatomical entity
A, C, E, G	LPS-assembly protein LptD	-	membrane organization membrane biogenesis membrane assembly cellular component organization cellular component biogenesis cellular component assembly cellular process cellular component organization or biogenesis cell envelope organization Gram-negative-bacterium-type cell outer membrane assembly external encapsulating structure organization response to organic substance response to stimulus response to chemical membrane organization membrane biogenesis membrane assembly cellular component organization cellular component biogenesis cellular component assembly cellular process cellular component organization or biogenesis cell envelope organization Gram-negative-bacterium-type cell outer membrane assembly external encapsulating structure organization response to organic substance response to stimulus response to chemical localization transport lipopolysaccharide transport macromolecule localization organic substance transport lipid localization lipid transport carbohydrate derivative transport establishment of localization	cell periphery cell outer membrane external encapsulating structure membrane cell envelope outer membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, D, F, H	IPR007485	LPS-assembly lipoprotein LptE	Family
A, C, E, G	IPR007543	LptD, C-terminal	Domain
A, C, E, G	IPR020889	LPS-assembly protein LptD	Family
A, C, E, G	IPR005653	Organic solvent tolerance-like, N-terminal	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E A, B, C, D, E, F, G, H	OPM				LPS assembly protein family (n=26, S=30)

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H	PDBTM	Annotated as membrane protein by PDBTM

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.