Annotations: 5IRI

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF21122	e5iriA1	A: a+b two layers	X: TBP-like	H: Kinase associated domain 1, KA1 (From Topology)	T: Kinase associated domain 1, KA1	F: PF21122	ECOD (1.6)
B	PF21122	e5iriB1	A: a+b two layers	X: TBP-like	H: Kinase associated domain 1, KA1 (From Topology)	T: Kinase associated domain 1, KA1	F: PF21122	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21122	BRSK1/2 KA1 domain (KA1_BRSK)	BRSK1/2 KA1 domain	This entry represents the KA1-like domain found in the brain-specific kinases BRSK1 and BRSK2 [1-2]. The BRSK/SAD kinase family includes serine/threonine-protein kinases that play crucial roles in neuronal polarization, centrosome duplication, cell c ...	This entry represents the KA1-like domain found in the brain-specific kinases BRSK1 and BRSK2 [1-2]. The BRSK/SAD kinase family includes serine/threonine-protein kinases that play crucial roles in neuronal polarization, centrosome duplication, cell cycle progression, and insulin secretion. Members phosphorylate a variety of substrates including CDC25B, CDC25C, MAPT/TAU, and WEE1, modulating their activities. Activation by STK11/LKB1 is a common regulatory mechanism, leading to phosphorylation of microtubule-associated proteins and influencing neuron polarization. These kinases also contribute to synaptic vesicle function and neurotransmitter release, regulate the mitotic cell cycle, and respond to DNA damage. Additionally, they are involved in actin cytoskeleton reorganization and may play a role in the apoptotic response to endoplasmic reticulum stress.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Serine/threonine-protein kinase BRSK1	molecular function inhibitor activity molecular function regulator activity tau-protein kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein serine kinase activity cation binding magnesium ion binding ion binding molecular function inhibitor activity molecular function regulator activity tau-protein kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein serine kinase activity cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding cytoskeletal protein binding protein binding gamma-tubulin binding tubulin binding kinase binding enzyme binding protein kinase binding protein serine/threonine kinase activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of neuron projection development multicellular organismal process axonogenesis regulation of cellular component organization regulation of cellular process cellular developmental process regulation of developmental process cell projection organization cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of neuron projection development multicellular organismal process axonogenesis regulation of cellular component organization regulation of cellular process cellular developmental process regulation of developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis regulation of axonogenesis cell differentiation anatomical structure development cellular component organization or biogenesis regulation of anatomical structure morphogenesis system development developmental process regulation of biological process plasma membrane bounded cell projection organization regulation of cell projection organization biological regulation nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development regulation of plasma membrane bounded cell projection organization trans-synaptic signaling cellular localization neurotransmitter secretion transport signaling secretion cell-cell signaling export from cell neurotransmitter transport establishment of localization cell communication chemical synaptic transmission localization signal release from synapse synaptic signaling secretion by cell signal release anterograde trans-synaptic signaling establishment of localization in cell microtubule organizing center organization microtubule cytoskeleton organization centrosome duplication organelle organization centrosome cycle microtubule-based process cell cycle cytoskeleton organization cell cycle process establishment of cell polarity establishment or maintenance of cell polarity regulation of cell cycle phase transition DNA damage checkpoint signaling G2/M transition of mitotic cell cycle mitotic G2 DNA damage checkpoint signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle mitotic G2/M transition checkpoint regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling mitotic DNA damage checkpoint signaling negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction regulation of cell cycle cell cycle G2/M phase transition negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process DNA integrity checkpoint signaling regulation of cell cycle G2/M phase transition negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic cell cycle process negative regulation of cell cycle G2/M phase transition signal transduction in response to DNA damage negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition protein phosphorylation organonitrogen compound metabolic process phosphorylation cellular metabolic process primary metabolic process organic substance metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process response to light stimulus response to radiation response to abiotic stimulus response to UV regulation of synaptic plasticity regulation of signaling modulation of chemical synaptic transmission regulation of trans-synaptic signaling regulation of cell communication regulation of biological quality behavior system process learning learning or memory nervous system process cognition associative learning synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse establishment of planar polarity epithelium development morphogenesis of an epithelium tissue development microtubule cytoskeleton organization involved in establishment of planar polarity tissue morphogenesis establishment of tissue polarity morphogenesis of a polarized epithelium	presynapse synapse cell junction cellular anatomical entity presynaptic active zone intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle presynapse synapse cell junction cellular anatomical entity presynaptic active zone intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle axon cell projection distal axon neuron projection plasma membrane bounded cell projection cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen transport vesicle intracellular vesicle endomembrane system cytoplasmic vesicle synaptic vesicle secretory vesicle vesicle exocytic vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B	IPR000719	Protein kinase domain	Domain
A, B	IPR015940	Ubiquitin-associated domain	Domain
A, B	IPR048622	BRSK1/2-like, UBA domain	Domain
A, B	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B	IPR008271	Serine/threonine-protein kinase, active site	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.