5I2M

CRYSTAL STRUCTURE OF VSV-INDIANA (MUDD-SUMMERS STRAIN) GLYCOPROTEIN UNDER ITS ACIDIC CONFORMATION

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5i2ma_	Multi-domain proteins (alpha and beta)	Viral glycoprotein ectodomain-like	Viral glycoprotein ectodomain-like	Spike glycoprotein-like	Spike glycoprotein	(Vesicular stomatitis Indiana virus strain Mudd-Summers ) [TaxId: 11279 ],	SCOPe (2.08)
B	d5i2mb_	Multi-domain proteins (alpha and beta)	Viral glycoprotein ectodomain-like	Viral glycoprotein ectodomain-like	Spike glycoprotein-like	Spike glycoprotein	(Vesicular stomatitis Indiana virus strain Mudd-Summers ) [TaxId: 11279 ],	SCOPe (2.08)
C	d5i2mc_	Multi-domain proteins (alpha and beta)	Viral glycoprotein ectodomain-like	Viral glycoprotein ectodomain-like	Spike glycoprotein-like	Spike glycoprotein	(Vesicular stomatitis Indiana virus strain Mudd-Summers ) [TaxId: 11279 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Spike glycoprotein-like	8021307	4002625	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Viral glycoprotein ectodomain-like	8033687	3001498	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Viral glycoprotein ectodomain-like	8033687	3001498	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Viral glycoprotein ectodomain-like	8033687	3001498	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00974	e5i2mA1	A: beta barrels	X: PH domain-like	H: first barrel domain in viral glycoproteins (From Topology)	T: first barrel domain in viral glycoproteins	F: PF00974	ECOD (1.6)
A	PF00974	e5i2mA2	A: beta barrels	X: PH domain-like	H: second barrel domain in viral glycoproteins (From Topology)	T: second barrel domain in viral glycoproteins	F: PF00974	ECOD (1.6)
A	PF00974	e5i2mA3	A: beta complex topology	X: Viral glycoprotein ectodomain-like (From Topology)	H: Viral glycoprotein ectodomain-like (From Topology)	T: Viral glycoprotein ectodomain-like	F: PF00974	ECOD (1.6)
B	PF00974	e5i2mB1	A: beta barrels	X: PH domain-like	H: first barrel domain in viral glycoproteins (From Topology)	T: first barrel domain in viral glycoproteins	F: PF00974	ECOD (1.6)
B	PF00974	e5i2mB3	A: beta barrels	X: PH domain-like	H: second barrel domain in viral glycoproteins (From Topology)	T: second barrel domain in viral glycoproteins	F: PF00974	ECOD (1.6)
B	PF00974	e5i2mB2	A: beta complex topology	X: Viral glycoprotein ectodomain-like (From Topology)	H: Viral glycoprotein ectodomain-like (From Topology)	T: Viral glycoprotein ectodomain-like	F: PF00974	ECOD (1.6)
C	PF00974	e5i2mC2	A: beta barrels	X: PH domain-like	H: first barrel domain in viral glycoproteins (From Topology)	T: first barrel domain in viral glycoproteins	F: PF00974	ECOD (1.6)
C	PF00974	e5i2mC1	A: beta barrels	X: PH domain-like	H: second barrel domain in viral glycoproteins (From Topology)	T: second barrel domain in viral glycoproteins	F: PF00974	ECOD (1.6)
C	PF00974	e5i2mC3	A: beta complex topology	X: Viral glycoprotein ectodomain-like (From Topology)	H: Viral glycoprotein ectodomain-like (From Topology)	T: Viral glycoprotein ectodomain-like	F: PF00974	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.640	Mainly Beta	Roll	SH3 type barrels.	Rhabdovirus spike glycoprotein G, lateral domain	CATH (4.3.0)
A	6.10.140.740	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
A	2.30.29.130	Mainly Beta	Roll	PH-domain like		CATH (4.3.0)
B	2.30.30.640	Mainly Beta	Roll	SH3 type barrels.	Rhabdovirus spike glycoprotein G, lateral domain	CATH (4.3.0)
B	6.10.140.740	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
B	2.30.29.130	Mainly Beta	Roll	PH-domain like		CATH (4.3.0)
C	2.30.30.640	Mainly Beta	Roll	SH3 type barrels.	Rhabdovirus spike glycoprotein G, lateral domain	CATH (4.3.0)
C	6.10.140.740	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
C	2.30.29.130	Mainly Beta	Roll	PH-domain like		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00974	Rhabdovirus spike glycoprotein (Rhabdo_glycop)	Rhabdovirus spike glycoprotein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Glycoprotein G	-	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell import into cell receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms transport viral life cycle establishment of localization vesicle-mediated transport biological process involved in interaction with host biological process involved in symbiotic interaction localization symbiont entry into host cell viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell import into cell receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms transport viral life cycle establishment of localization vesicle-mediated transport biological process involved in interaction with host biological process involved in symbiotic interaction localization symbiont entry into host cell clathrin-dependent endocytosis symbiont entry into host cellular process clathrin-dependent endocytosis of virus by host cell receptor-mediated endocytosis endocytosis endocytosis involved in viral entry into host cell transport of virus virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host	virion component viral membrane viral envelope membrane cellular anatomical entity virion membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR001903	Rhabdovirus glycoprotein	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C	OPM	Transmembrane	Bitopic proteins	Viral membrane fusion glycoprotein	Rhabdovirus spike glycoprotein

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.