5HFM

Gp41-targeting HIV-1 fusion inhibitors with hook-like Ile-Asp-Leu tail

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5hfma1	Coiled coil proteins	Stalk segment of viral fusion proteins	Virus ectodomain	Virus ectodomain	Retrovius gp41 protease-resistant core	HIV-1 (Human immunodeficiency virus 1 ) [TaxId: 11676 ], (Human immunodeficiency virus 1 ) [TaxId: 11676 ],	SCOPe (2.08)
A	d5hfma2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HIV-1 (Human immunodeficiency virus 1 ) [TaxId: 11676 ], (Human immunodeficiency virus 1 ) [TaxId: 11676 ],	SCOPe (2.08)
D	d5hfmd1	Coiled coil proteins	Stalk segment of viral fusion proteins	Virus ectodomain	Virus ectodomain	Retrovius gp41 protease-resistant core	HIV-1 (Human immunodeficiency virus 1 ) [TaxId: 11676 ], (Human immunodeficiency virus 1 ) [TaxId: 11676 ],	SCOPe (2.08)
D	d5hfmd2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HIV-1 (Human immunodeficiency virus 1 ) [TaxId: 11676 ], (Human immunodeficiency virus 1 ) [TaxId: 11676 ],	SCOPe (2.08)
E	d5hfme1	Coiled coil proteins	Stalk segment of viral fusion proteins	Virus ectodomain	Virus ectodomain	Retrovius gp41 protease-resistant core	HIV-1 (Human immunodeficiency virus 1 ) [TaxId: 11676 ], (Human immunodeficiency virus 1 ) [TaxId: 11676 ],	SCOPe (2.08)
E	d5hfme2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HIV-1 (Human immunodeficiency virus 1 ) [TaxId: 11676 ], (Human immunodeficiency virus 1 ) [TaxId: 11676 ],	SCOPe (2.08)
F	d5hfmf1	Coiled coil proteins	Stalk segment of viral fusion proteins	Virus ectodomain	Virus ectodomain	Retrovius gp41 protease-resistant core	HIV-1 (Human immunodeficiency virus 1 ) [TaxId: 11676 ], (Human immunodeficiency virus 1 ) [TaxId: 11676 ],	SCOPe (2.08)
F	d5hfmf2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HIV-1 (Human immunodeficiency virus 1 ) [TaxId: 11676 ], (Human immunodeficiency virus 1 ) [TaxId: 11676 ],	SCOPe (2.08)
B	d5hfmb1	Coiled coil proteins	Stalk segment of viral fusion proteins	Virus ectodomain	Virus ectodomain	Retrovius gp41 protease-resistant core	HIV-1 (Human immunodeficiency virus 1 ) [TaxId: 11676 ], (Human immunodeficiency virus 1 ) [TaxId: 11676 ],	SCOPe (2.08)
B	d5hfmb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HIV-1 (Human immunodeficiency virus 1 ) [TaxId: 11676 ], (Human immunodeficiency virus 1 ) [TaxId: 11676 ],	SCOPe (2.08)
C	d5hfmc1	Coiled coil proteins	Stalk segment of viral fusion proteins	Virus ectodomain	Virus ectodomain	Retrovius gp41 protease-resistant core	HIV-1 (Human immunodeficiency virus 1 ) [TaxId: 11676 ], (Human immunodeficiency virus 1 ) [TaxId: 11676 ],	SCOPe (2.08)
C	d5hfmc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HIV-1 (Human immunodeficiency virus 1 ) [TaxId: 11676 ], (Human immunodeficiency virus 1 ) [TaxId: 11676 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e5hfmA1	A: a+b duplicates or obligate multimers	X: MPER trimer (From Topology)	H: MPER trimer (From Topology)	T: MPER trimer	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e5hfmD1	A: a+b duplicates or obligate multimers	X: MPER trimer (From Topology)	H: MPER trimer (From Topology)	T: MPER trimer	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e5hfmE1	A: a+b duplicates or obligate multimers	X: MPER trimer (From Topology)	H: MPER trimer (From Topology)	T: MPER trimer	F: F_UNCLASSIFIED	ECOD (1.6)
F	F_UNCLASSIFIED	e5hfmF1	A: a+b duplicates or obligate multimers	X: MPER trimer (From Topology)	H: MPER trimer (From Topology)	T: MPER trimer	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e5hfmB1	A: a+b duplicates or obligate multimers	X: MPER trimer (From Topology)	H: MPER trimer (From Topology)	T: MPER trimer	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e5hfmC1	A: a+b duplicates or obligate multimers	X: MPER trimer (From Topology)	H: MPER trimer (From Topology)	T: MPER trimer	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.287.210	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
D	1.10.287.210	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
E	1.10.287.210	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
F	1.10.287.210	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
B	1.10.287.210	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
C	1.10.287.210	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00517	Retroviral envelope protein (GP41)	Retroviral envelope protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Envelope glycoprotein gp160,gp41 CHR region	structural molecule activity	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane cellular process cellular component organization or biogenesis regulation of establishment of T cell polarity regulation of establishment or maintenance of cell polarity multicellular organismal process establishment of lymphocyte polarity regulation of cellular process viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane cellular process cellular component organization or biogenesis regulation of establishment of T cell polarity regulation of establishment or maintenance of cell polarity multicellular organismal process establishment of lymphocyte polarity regulation of cellular process regulation of leukocyte activation establishment of T cell polarity positive regulation of biological process regulation of cell activation positive regulation of leukocyte cell-cell adhesion establishment or maintenance of cell polarity lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion cell-cell adhesion T cell activation positive regulation of establishment of T cell polarity positive regulation of leukocyte activation regulation of multicellular organismal process regulation of immune system process regulation of cell-cell adhesion positive regulation of immune system process positive regulation of cellular process regulation of biological process positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion cell activation biological regulation regulation of T cell activation establishment of cell polarity regulation of establishment of cell polarity immune system process regulation of leukocyte cell-cell adhesion positive regulation of multicellular organismal process regulation of lymphocyte activation symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction evasion of host immune response modulation by symbiont of host process response to host immune response response to host response to external biotic stimulus modulation of process of another organism protein localization regulation of localization cellular localization regulation of protein localization positive regulation of receptor clustering positive regulation of protein localization to membrane localization within membrane protein localization to membrane localization regulation of cellular localization cellular macromolecule localization macromolecule localization receptor clustering positive regulation of protein localization regulation of receptor clustering regulation of protein localization to membrane virion attachment to host cell adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host modulation by virus of host process virus-mediated perturbation of host defense response modulation by virus of host cellular process plasma membrane raft distribution regulation of cellular component organization positive regulation of cellular component organization plasma membrane raft polarization plasma membrane organization membrane raft organization endomembrane system organization membrane raft distribution plasma membrane raft localization membrane raft polarization regulation of plasma membrane raft polarization membrane raft localization regulation of plasma membrane organization positive regulation of plasma membrane raft polarization import into cell receptor-mediated endocytosis of virus by host cell transport establishment of localization vesicle-mediated transport symbiont entry into host cell clathrin-dependent endocytosis symbiont entry into host clathrin-dependent endocytosis of virus by host cell receptor-mediated endocytosis endocytosis endocytosis involved in viral entry into host cell transport of virus organelle organization actin cytoskeleton organization actin filament organization actin filament-based process supramolecular fiber organization cytoskeleton organization viral gene expression viral protein processing	membrane cellular anatomical entity virion component virion membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host cell membrane host cell cytoplasm part host intracellular organelle host cell endosome membrane host cell cytoplasm host cell part host cell endosome membrane cellular anatomical entity virion component virion membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host cell membrane host cell cytoplasm part host intracellular organelle host cell endosome membrane host cell cytoplasm host cell part host cell endosome host intracellular region viral membrane viral envelope host cell plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR000777	Human immunodeficiency virus 1, envelope glycoprotein Gp120	Domain
A, B, C, D, E A, B, C, D, E, F	IPR036377	Gp120 core superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR000328	Retroviral envelope protein GP41-like	Domain
A, B, C, D, E A, B, C, D, E, F	IPR037527	Envelope glycoprotein Gp160	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.