Annotations: 5HBT

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth B]	d5hbtb1	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A [auth B]	d5hbtb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth C]	d5hbtc2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	automated matches	(Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B [auth C]	d5hbtc1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	(Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D [auth A]	d5hbta_	Small proteins	Snake toxin-like	Snake toxin-like	Snake venom toxins	Bungarotoxin	(Bungarus multicinctus ) [TaxId: 8616 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PF02931	e5hbtB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: PF02931	ECOD (1.6)
B [auth C]	PF07654	e5hbtC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
B [auth C]	PF07686	e5hbtC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
C [auth D]	PF07654	e5hbtD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
C [auth D]	PF07686	e5hbtD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
D [auth A]	PF21947	e5hbtA1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: PF21947	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
B [auth C]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C [auth D]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D [auth A]	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B [auth C]	Light Chain	IGKV22	Kappa	acetylcholine receptor subunit alpha 1	SAbDab (2024-05-03)
C [auth D]	Heavy Chain	IGHV2	-	acetylcholine receptor subunit alpha 1	SAbDab (2024-05-03)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B]	PF02931	Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD)	Neurotransmitter-gated ion-channel ligand binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	Acetylcholine receptor subunit alpha 1	neurotransmitter receptor activity postsynaptic neurotransmitter receptor activity molecular transducer activity signaling receptor activity transmembrane signaling receptor activity acetylcholine receptor activity cation binding acetylcholine binding ion binding binding small molecule binding passive transmembrane transporter activity monoatomic ion channel activity channel activity neurotransmitter receptor activity postsynaptic neurotransmitter receptor activity molecular transducer activity signaling receptor activity transmembrane signaling receptor activity acetylcholine receptor activity cation binding acetylcholine binding ion binding binding small molecule binding passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity transmitter-gated monoatomic ion channel activity gated channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential transmitter-gated channel activity monoatomic cation transmembrane transporter activity acetylcholine-gated monoatomic cation-selective channel activity ligand-gated monoatomic cation channel activity excitatory extracellular ligand-gated monoatomic ion channel activity monoatomic cation channel activity	cellular component organization cell junction organization neuromuscular junction development cellular process synapse organization cellular component organization or biogenesis multicellular organismal movement musculoskeletal movement multicellular organismal process system process nervous system process neuromuscular process skeletal muscle contraction muscle contraction cellular component organization cell junction organization neuromuscular junction development cellular process synapse organization cellular component organization or biogenesis multicellular organismal movement musculoskeletal movement multicellular organismal process system process nervous system process neuromuscular process skeletal muscle contraction muscle contraction muscle system process striated muscle contraction developmental process developmental growth skeletal muscle tissue development animal organ development growth tissue development muscle structure development skeletal muscle organ development skeletal muscle tissue growth anatomical structure development muscle tissue development muscle organ development cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation signal transduction cell communication trans-synaptic signaling cell-cell signaling chemical synaptic transmission synaptic signaling anterograde trans-synaptic signaling neuromuscular synaptic transmission action potential transmission of nerve impulse neuronal action potential regulation of biological quality regulation of membrane potential response to chemical response to nicotine synaptic transmission, cholinergic cellular homeostasis homeostatic process muscle cell cellular homeostasis neuron cellular homeostasis	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane cell surface postsynaptic specialization membrane postsynaptic specialization organelle cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane cell surface postsynaptic specialization membrane postsynaptic specialization organelle cell projection neuron projection plasma membrane bounded cell projection neuromuscular junction protein-containing complex plasma membrane protein complex membrane protein complex transporter complex receptor complex acetylcholine-gated channel complex transmembrane transporter complex plasma membrane signaling receptor complex monoatomic ion channel complex
B [auth C]	Fab35, Light Chain	-	-	-
C [auth D]	Fab35, Heavy Chain	-	-	-
D [auth A]	Alpha-bungarotoxin isoform V31	channel regulator activity ion channel regulator activity molecular function regulator activity transporter regulator activity neurotransmitter receptor regulator activity acetylcholine receptor regulator activity molecular function inhibitor activity acetylcholine receptor inhibitor activity signaling receptor inhibitor activity signaling receptor regulator activity toxin activity	-	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B]	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
A [auth B]	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
A [auth B]	IPR002394	Nicotinic acetylcholine receptor	Family
A [auth B]	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain	Domain
A [auth B]	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
A [auth B]	IPR018000	Neurotransmitter-gated ion-channel, conserved site	Conserved Site
A [auth B]	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
A [auth B]	IPR006201	Neurotransmitter-gated ion-channel	Family
D [auth A]	IPR018354	Snake toxin, conserved site	Conserved Site
D [auth A]	IPR045860	Snake toxin-like superfamily	Homologous Superfamily
D [auth A]	IPR003571	Snake three-finger toxin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B]	Pharos: P02708	congenital myasthenic syndrome myasthenic syndrome, congenital, 1B, fast-channel lethal multiple pterygium syndrome multiple pterygium syndrome congenital myasthenic syndrome 1A Fibrosis myopathy peripheral neuropathy amyotrophic lateral sclerosis Becker muscular dystrophy Emery-Dreifuss muscular dystrophy malignant glioma non-immune hydrops fetalis pituitary cancer arthrogryposis congenital myasthenic syndrome myasthenic syndrome, congenital, 1B, fast-channel lethal multiple pterygium syndrome multiple pterygium syndrome congenital myasthenic syndrome 1A Fibrosis myopathy peripheral neuropathy amyotrophic lateral sclerosis Becker muscular dystrophy Emery-Dreifuss muscular dystrophy malignant glioma non-immune hydrops fetalis pituitary cancer arthrogryposis juvenile dermatomyositis limb-girdle muscular dystrophy medulloblastoma peripheral nervous system disease psoriasis atrial fibrillation ulcerative colitis Duchenne muscular dystrophy large cell medulloblastoma lung cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.