The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate ...
The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF [2]. This is the HUS (homology upstream of Sec7) domain of Sec7 and related proteins such as protein Mon2 and BIG1-like proteins, which plays a regulatory role [3,4] together with DCB domain (Pfam:PF16213).
Mon2/Sec7/BIG1-like, dimerisation and cyclophilin-binding domain
DCB domain is found at the N-terminal of Mon2 and BIG1-like proteins from metazoa, and in fungal homologues like Sec7 and Gea1/2 [3,4]. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required ...
DCB domain is found at the N-terminal of Mon2 and BIG1-like proteins from metazoa, and in fungal homologues like Sec7 and Gea1/2 [3,4]. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis [1,2]. This domain is sufficient for targeting BIG1 to the Golgi.