5GV3

Crystal structure of the membrane-distal domain of mouse lysosome-associated membrane protein 2 (LAMP-2)

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01299	e5gv3A1	A: beta meanders	X: lysosome-associated membrane protein LAMP-3 (From Topology)	H: lysosome-associated membrane protein LAMP-3 (From Topology)	T: lysosome-associated membrane protein LAMP-3	F: PF01299	ECOD (1.6)
B	PF01299	e5gv3B1	A: beta meanders	X: lysosome-associated membrane protein LAMP-3 (From Topology)	H: lysosome-associated membrane protein LAMP-3 (From Topology)	T: lysosome-associated membrane protein LAMP-3	F: PF01299	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01299	Lysosome-associated membrane glycoprotein 2-like, luminal domains (Lamp2-like_luminal)	Lysosome-associated membrane glycoprotein 2-like, luminal domains	This domain is found in a group of animal proteins that includes Lysosome-associated membrane glycoprotein 2 from humans (Lamp2). Lamp2 is an integral membrane protein that plays an important role in chaperone-mediated autophagy (CMA), targeting pert ...	This domain is found in a group of animal proteins that includes Lysosome-associated membrane glycoprotein 2 from humans (Lamp2). Lamp2 is an integral membrane protein that plays an important role in chaperone-mediated autophagy (CMA), targeting pertinent proteins for lysosomal degradation. This protein is organised into two conserved luminal domains (this entry), a single transmembrane (TM) domain (Pfam:PF21222), and a short C-terminal cytosolic tail. It adopts a trimeric configuration [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Lysosome-associated membrane glycoprotein 2	protein binding binding protein domain specific binding molecular function inhibitor activity channel regulator activity transporter inhibitor activity ion channel inhibitor activity ion channel regulator activity molecular function regulator activity transporter regulator activity channel inhibitor activity enzyme binding	regulation of protein stability biological regulation regulation of biological quality protein stabilization cellular component disassembly catabolic process macroautophagy protein-containing complex organization cellular metabolic process autophagy protein-containing complex disassembly cellular catabolic process cellular component organization autophagosome maturation regulation of protein stability biological regulation regulation of biological quality protein stabilization cellular component disassembly catabolic process macroautophagy protein-containing complex organization cellular metabolic process autophagy protein-containing complex disassembly cellular catabolic process cellular component organization autophagosome maturation cellular process metabolic process cellular component organization or biogenesis process utilizing autophagic mechanism homeostatic process intracellular pH reduction regulation of intracellular pH lysosome organization vacuolar acidification lysosomal lumen acidification intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis regulation of lysosomal lumen pH regulation of cellular pH intracellular monoatomic ion homeostasis vacuole organization lytic vacuole organization organelle organization cellular homeostasis chemical homeostasis cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus cellular response to stress response to stress response to starvation cellular response to starvation protein localization establishment of protein localization cellular localization nitrogen compound transport transport protein targeting to vacuole involved in autophagy protein targeting establishment of protein localization to vacuole protein targeting to lysosome involved in chaperone-mediated autophagy lysosomal transport macromolecule catabolic process chaperone-mediated autophagy localization organic substance metabolic process protein targeting to lysosome cellular macromolecule localization establishment of localization in cell protein metabolic process protein targeting to vacuole organonitrogen compound catabolic process organonitrogen compound metabolic process organic substance transport primary metabolic process protein localization to vacuole intracellular transport protein catabolic process establishment of localization protein localization to lysosome establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle vacuolar transport macromolecule metabolic process organic substance catabolic process intracellular protein transport protein catabolic process in the vacuole lysosomal protein catabolic process muscle cell cellular homeostasis	membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle platelet dense granule membrane intracellular anatomical structure intracellular vesicle membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle platelet dense granule membrane intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle platelet dense granule secretory granule secretory vesicle cytoplasm organelle membrane secretory granule membrane cell periphery plasma membrane endosome membrane endosome late endosome membrane late endosome lytic vacuole vacuole lysosome vacuolar membrane protein-containing complex chaperone-mediated autophagy translocation complex membrane protein complex lytic vacuole membrane lysosomal membrane autophagosome membrane autophagosome phagocytic vesicle phagocytic vesicle membrane endocytic vesicle membrane endocytic vesicle membrane-enclosed lumen vacuolar lumen lysosomal lumen intracellular organelle lumen organelle lumen lysosomal matrix autolysosome secondary lysosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR048524	Lysosome-associated membrane glycoprotein 2-like, transmembrane domain	Domain
A, B	IPR002000	Lysosome-associated membrane glycoprotein	Family
A, B	IPR048528	Lysosome-associated membrane glycoprotein 2-like, luminal domains	Domain
A, B	IPR018134	Lysosome-associated membrane glycoprotein, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.