5GV0

Crystal structure of the membrane-proximal domain of mouse lysosome-associated membrane protein 1 (LAMP-1)

External Resource: Annotation


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad5gv0a1 All beta proteins Pseudo beta-prism II LAMP conserved domain-like automated matches automated matches Mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
Ad5gv0a2 Artifacts Tags Tags Tags N-terminal Tags Mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APF01299e5gv0A1 A: beta meandersX: lysosome-associated membrane protein LAMP-3 (From Topology)H: lysosome-associated membrane protein LAMP-3 (From Topology)T: lysosome-associated membrane protein LAMP-3F: PF01299ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.40.160.110 Mainly Beta Beta Barrel Porin CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF01299Lysosome-associated membrane glycoprotein 2-like, luminal domains (Lamp2-like_luminal)Lysosome-associated membrane glycoprotein 2-like, luminal domainsThis domain is found in a group of animal proteins that includes Lysosome-associated membrane glycoprotein 2 from humans (Lamp2). Lamp2 is an integral membrane protein that plays an important role in chaperone-mediated autophagy (CMA), targeting pert ...This domain is found in a group of animal proteins that includes Lysosome-associated membrane glycoprotein 2 from humans (Lamp2). Lamp2 is an integral membrane protein that plays an important role in chaperone-mediated autophagy (CMA), targeting pertinent proteins for lysosomal degradation. This protein is organised into two conserved luminal domains (this entry), a single transmembrane (TM) domain (Pfam:PF21222), and a short C-terminal cytosolic tail. It adopts a trimeric configuration [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Lysosome-associated membrane glycoprotein 1

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR048524Lysosome-associated membrane glycoprotein 2-like, transmembrane domainDomain
IPR002000Lysosome-associated membrane glycoproteinFamily
IPR048528Lysosome-associated membrane glycoprotein 2-like, luminal domainsDomain
IPR018134Lysosome-associated membrane glycoprotein, conserved siteConserved Site