5FR8

Crystal structure of the siderophore receptor PirA from Acinetobacter baumannii

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5fr8a_	Membrane and cell surface proteins and peptides	Transmembrane beta-barrels	Porins	automated matches	automated matches	(Acinetobacter baumannii ) [TaxId: 470 ],	SCOPe (2.08)
B	d5fr8b_	Membrane and cell surface proteins and peptides	Transmembrane beta-barrels	Porins	automated matches	automated matches	(Acinetobacter baumannii ) [TaxId: 470 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Ligand-gated protein channel	8072642	4003084	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Porins	8072643	3000224	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Porins	8072643	3000224	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00593	e5fr8A2	A: beta barrels	X: Outer membrane meander beta-barrels	H: Porins	T: Ligand-gated protein channel	F: PF00593	ECOD (1.6)
A	PF07715	e5fr8A1	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: TonB-dependent receptor plug domain (From Topology)	T: TonB-dependent receptor plug domain	F: PF07715	ECOD (1.6)
B	PF00593	e5fr8B2	A: beta barrels	X: Outer membrane meander beta-barrels	H: Porins	T: Ligand-gated protein channel	F: PF00593	ECOD (1.6)
B	PF07715	e5fr8B1	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: TonB-dependent receptor plug domain (From Topology)	T: TonB-dependent receptor plug domain	F: PF07715	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00593	TonB dependent receptor (TonB_dep_Rec)	TonB dependent receptor	-	Family
A, B	PF07715	TonB-dependent Receptor Plug Domain (Plug)	TonB-dependent Receptor Plug Domain	The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors ([1]). It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens ...	The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors ([1]). It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	TONB-DEPENDENT SIDEROPHORE RECEPTOR	wide pore channel activity passive transmembrane transporter activity channel activity porin activity transporter activity transmembrane transporter activity molecular transducer activity signaling receptor activity siderophore-iron transmembrane transporter activity	-	protein-containing complex membrane pore complex membrane protein complex cellular anatomical entity cell periphery cell outer membrane external encapsulating structure cell envelope outer membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR039426	TonB-dependent receptor-like	Family
A, B	IPR037066	TonB-dependent receptor, plug domain superfamily	Homologous Superfamily
A, B	IPR010917	TonB-dependent receptor, conserved site	Conserved Site
A, B	IPR010105	TonB-dependent siderophore receptor	Family
A, B	IPR036942	TonB-dependent receptor-like, beta-barrel domain superfamily	Homologous Superfamily
A, B	IPR000531	TonB-dependent receptor-like, beta-barrel	Domain
A, B	IPR012910	TonB-dependent receptor, plug domain	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Beta-barrel transmembrane	Ligand-gated protein channels (n=22,S=24)	Outer Membrane Receptor (OMR)

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.