5FIP

Discovery and characterization of a novel thermostable and highly halotolerant GH5 cellulase from an Icelandic hot spring isolate

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	(Trans)glycosidases	8067794	3000313	SCOP2B (2022-06-29)
D	SCOP2 Family	beta-glycanases	8067793	4003164	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	(Trans)glycosidases	8067794	3000313	SCOP2 (2022-06-29)
A	SCOP2B Superfamily	(Trans)glycosidases	8067794	3000313	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	(Trans)glycosidases	8067794	3000313	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF00150	e5fipB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00150	ECOD (1.6)
D	PF00150	e5fipD1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00150	ECOD (1.6)
A	PF00150	e5fipA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00150	ECOD (1.6)
C	PF00150	e5fipC1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00150	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
D	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
A	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
C	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00150	Cellulase (glycosyl hydrolase family 5) (Cellulase)	Cellulase (glycosyl hydrolase family 5)	-	Domain
A, B, C, D	PF03424	Carbohydrate binding domain (family 17/28) (CBM_17_28)	Carbohydrate binding domain (family 17/28)	This entry represents two tandem carbohydrate binding domains from CBM17 and CBM28 families. CBM17 binds to amorphous cellulose and soluble beta-1,4-glucans. CBM28 does not compete with CBM17 modules when binding to non-crystalline cellulose and it i ...	This entry represents two tandem carbohydrate binding domains from CBM17 and CBM28 families. CBM17 binds to amorphous cellulose and soluble beta-1,4-glucans. CBM28 does not compete with CBM17 modules when binding to non-crystalline cellulose and it is closely related to CBM17, according to sequence and structural conservation which suggests that they have evolved through gene duplication and subsequent divergence.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	GH5 CELLULASE	hydrolase activity, acting on glycosyl bonds cellulase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity	carbohydrate metabolic process catabolic process glucan catabolic process beta-glucan metabolic process carbohydrate catabolic process primary metabolic process macromolecule catabolic process polysaccharide metabolic process organic substance metabolic process glucan metabolic process beta-glucan catabolic process polysaccharide catabolic process metabolic process cellulose catabolic process carbohydrate metabolic process catabolic process glucan catabolic process beta-glucan metabolic process carbohydrate catabolic process primary metabolic process macromolecule catabolic process polysaccharide metabolic process organic substance metabolic process glucan metabolic process beta-glucan catabolic process polysaccharide catabolic process metabolic process cellulose catabolic process macromolecule metabolic process organic substance catabolic process cellulose metabolic process	membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR005086	Carbohydrate binding module family 17/28	Domain
A, B, C, D	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A, B, C, D	IPR001547	Glycoside hydrolase, family 5	Domain
A, B, C, D	IPR018087	Glycoside hydrolase, family 5, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.