5CJ1

Crystal structure of the coiled coil of MYH7 residues 1526 to 1571 fused to Gp7

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF11418	Phi29 scaffolding protein (Scaffolding_pro)	Phi29 scaffolding protein	-	Family
A, B, C, D, E A, B, C, D, E, F, G, H	PF01576	Myosin tail (Myosin_tail_1)	Myosin tail	-	Coiled-coil

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Gp7-MYH7-(1526-1571) chimera protein	DNA binding binding organic cyclic compound binding nucleic acid binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding DNA binding binding organic cyclic compound binding nucleic acid binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding calmodulin binding cytoskeletal motor activity microfilament motor activity ATP-dependent activity	virion assembly viral process viral life cycle heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process regulation of biological quality virion assembly viral process viral life cycle heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process regulation of biological quality heart contraction blood circulation regulation of heart rate muscle contraction muscle system process striated muscle contraction ribose phosphate metabolic process ATP metabolic process carbohydrate derivative metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process organic substance metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process purine nucleoside triphosphate metabolic process organonitrogen compound metabolic process cellular metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process organic cyclic compound metabolic process organophosphate metabolic process metabolic process cellular process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process regulation of the force of heart contraction regulation of muscle adaptation striated muscle adaptation response to stimulus transition between fast and slow fiber regulation of skeletal muscle adaptation regulation of muscle system process muscle adaptation regulation of response to stimulus skeletal muscle adaptation slow-twitch skeletal muscle fiber contraction twitch skeletal muscle contraction multicellular organismal movement musculoskeletal movement regulation of twitch skeletal muscle contraction regulation of skeletal muscle contraction regulation of slow-twitch skeletal muscle fiber contraction nervous system process neuromuscular process skeletal muscle contraction voluntary skeletal muscle contraction regulation of striated muscle contraction regulation of muscle contraction muscle filament sliding actin filament-based process actin-mediated cell contraction actin filament-based movement actin-myosin filament sliding cardiac muscle contraction developmental process heart development multicellular organism development anatomical structure development animal organ development adult heart development circulatory system development system development ventricular cardiac muscle tissue morphogenesis heart morphogenesis striated muscle tissue development muscle structure development ventricular cardiac muscle tissue development cardiac chamber development animal organ morphogenesis muscle tissue development muscle organ development cardiac chamber morphogenesis cardiac muscle tissue development tissue development muscle tissue morphogenesis anatomical structure morphogenesis tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis cardiac ventricle development muscle organ morphogenesis regulation of the force of skeletal muscle contraction regulation of skeletal muscle contraction by chemo-mechanical energy conversion cellular developmental process cellular component assembly involved in morphogenesis non-membrane-bounded organelle assembly cell development muscle cell differentiation cellular component organization cellular component biogenesis striated muscle cell development cellular anatomical entity morphogenesis cellular component assembly muscle cell development cell differentiation sarcomere organization cellular component organization or biogenesis actomyosin structure organization actin cytoskeleton organization organelle assembly myofibril assembly organelle organization anatomical structure formation involved in morphogenesis striated muscle cell differentiation supramolecular fiber organization cytoskeleton organization muscle hypertrophy striated muscle hypertrophy cardiac muscle adaptation response to stress cardiac muscle hypertrophy cardiac muscle hypertrophy in response to stress muscle hypertrophy in response to stress	protein-containing complex viral capsid virion component viral scaffold intracellular anatomical structure cellular anatomical entity Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm protein-containing complex viral capsid virion component viral scaffold intracellular anatomical structure cellular anatomical entity Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle actin cytoskeleton myosin complex cytoskeleton myosin II complex muscle myosin complex myosin filament actin filament bundle actomyosin stress fiber contractile actin filament bundle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR038032	Capsid assembly scaffolding protein Gp7	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR024374	Bacteriophage phi-29 scaffolding protein Gp7	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000048	IQ motif, EF-hand binding site	Binding Site
A, B, C, D, E A, B, C, D, E, F, G, H	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR014751	DNA repair protein XRCC4-like, C-terminal	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR001609	Myosin head, motor domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR002928	Myosin tail	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR004009	Myosin, N-terminal, SH3-like	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR008989	Myosin S1 fragment, N-terminal	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H	Pharos: P12883	myopathy, myosin storage, autosomal dominant dilated cardiomyopathy myopathy, myosin storage, autosomal recessive hypertrophic cardiomyopathy left ventricular noncompaction congenital fiber-type disproportion myopathy dilated cardiomyopathy 1S MYH7-related skeletal myopathy distal myopathy Ebstein anomaly hypertrophic cardiomyopathy 1 cardiomyopathy myocardial infarction tibial muscular dystrophy congenital structural myopathy myopathy, myosin storage, autosomal dominant dilated cardiomyopathy myopathy, myosin storage, autosomal recessive hypertrophic cardiomyopathy left ventricular noncompaction congenital fiber-type disproportion myopathy dilated cardiomyopathy 1S MYH7-related skeletal myopathy distal myopathy Ebstein anomaly hypertrophic cardiomyopathy 1 cardiomyopathy myocardial infarction tibial muscular dystrophy congenital structural myopathy atrial fibrillation MYH7-related late-onset scapuloperoneal muscular dystrophy centronuclear myopathy coronary stenosis familial dilated cardiomyopathy heart disease arthrogryposis LEFT VENTRICULAR NONCOMPACTION 5 autosomal dominant centronuclear myopathy scapuloperoneal myopathy Charcot-Marie-Tooth disease familial hypertrophic cardiomyopathy hyaline body myopathy malignant ependymoma psoriasis X-linked centronuclear myopathy dilated cardiomyopathy 1A familial isolated dilated cardiomyopathy autosomal recessive centronuclear myopathy myopathy myotonia congenita restrictive cardiomyopathy tubular aggregate myopathy X-linked Emery-Dreifuss muscular dystrophy

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.