4ZKC
The chemokine binding protein of orf virus complexed with CCL7
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | d4zkcb_ | Alpha and beta proteins (a+b) | IL8-like | Interleukin 8-like chemokines | Interleukin 8-like chemokines | automated matches | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF02250 | e4zkcA1 | A: beta sandwiches | X: Soluble secreted chemokine inhibitor, VCCI (From Topology) | H: Soluble secreted chemokine inhibitor, VCCI (From Topology) | T: Soluble secreted chemokine inhibitor, VCCI | F: PF02250 | ECOD (1.6) |
B | PF00048 | e4zkcB1 | A: beta barrels | X: IL8-related (From Homology) | H: IL8-related | T: IL8 | F: PF00048 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B | 2.40.50.40 | Mainly Beta | Beta Barrel | OB fold (Dihydrolipoamide Acetyltransferase, E2P) | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF02250 | Viral chemokine binding protein (Orthopox_35kD) | Viral chemokine binding protein | This family of orthopoxvirus secreted proteins (also known as T1 and A41) interact with members of both the CC and CXC superfamilies of chemokines. It has been suggested that these secreted proteins modulate leukocyte influx into virus-infected ti ... | Domain | |
PF00048 | Small cytokines (intecrine/chemokine), interleukin-8 like (IL8) | Small cytokines (intecrine/chemokine), interleukin-8 like | Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR003184 | Viral chemokine binding protein | Family | |
IPR036540 | Poxvirus chemokine inhibitor superfamily | Homologous Superfamily | |
IPR001811 | Chemokine interleukin-8-like domain | Domain | |
IPR000827 | CC chemokine, conserved site | Conserved Site | |
IPR036048 | Chemokine interleukin-8-like superfamily | Homologous Superfamily | |
IPR039809 | Chemokine beta/gamma/delta | Family |