4YX7

Complex of SpaO(SPOA1,2) and OrgB(APAR)::T4lysozyme fusion protein

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Surface presentation of antigens (SPOA)	8098672	3001883	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Surface presentation of antigens (SPOA)	8098672	3001883	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Lysozyme-like	8033861	3001879	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Lysozyme-like	8033861	3001879	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e4yx7A1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Surface presentation of antigens (SPOA)	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e4yx7D1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Surface presentation of antigens (SPOA)	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF01052	e4yx7B1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Surface presentation of antigens (SPOA)	F: PF01052	ECOD (1.6)
E	PF01052	e4yx7E1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Surface presentation of antigens (SPOA)	F: PF01052	ECOD (1.6)
C	PF00959	e4yx7C1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: PF00959	ECOD (1.6)
F	PF00959	e4yx7F1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: PF00959	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.30.330.10	Mainly Beta	Roll	Surface presentation of antigens (SPOA)	SpoA-like	CATH (4.3.0)
E	2.30.330.10	Mainly Beta	Roll	Surface presentation of antigens (SPOA)	SpoA-like	CATH (4.3.0)
C	1.10.530.40	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)
F	1.10.530.40	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, E	PF01052	Type III flagellar switch regulator (C-ring) FliN C-term (FliMN_C)	Type III flagellar switch regulator (C-ring) FliN C-term	-	Family
C, F	PF00959	Phage lysozyme (Phage_lysozyme)	Phage lysozyme	This family includes lambda phage lysozyme and E. coli endolysin.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	Surface presentation of antigens protein SpaO	-	positive chemotaxis chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion bacterial-type flagellum-dependent swarming motility bacterial-type flagellum-dependent cell motility cellular process cell motility archaeal or bacterial-type flagellum-dependent cell motility cilium or flagellum-dependent cell motility protein localization positive chemotaxis chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion bacterial-type flagellum-dependent swarming motility bacterial-type flagellum-dependent cell motility cellular process cell motility archaeal or bacterial-type flagellum-dependent cell motility cilium or flagellum-dependent cell motility protein localization establishment of protein localization cellular localization nitrogen compound transport transport secretion organic substance transport protein secretion by the type III secretion system establishment of protein localization to extracellular region export from cell protein secretion establishment of localization protein localization to extracellular region transmembrane transport localization secretion by cell protein transmembrane transport protein transport cellular macromolecule localization macromolecule localization	-
B, E	Surface presentation of antigens protein SpaO	-	positive chemotaxis chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion bacterial-type flagellum-dependent swarming motility bacterial-type flagellum-dependent cell motility cellular process cell motility archaeal or bacterial-type flagellum-dependent cell motility cilium or flagellum-dependent cell motility protein localization positive chemotaxis chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion bacterial-type flagellum-dependent swarming motility bacterial-type flagellum-dependent cell motility cellular process cell motility archaeal or bacterial-type flagellum-dependent cell motility cilium or flagellum-dependent cell motility protein localization establishment of protein localization cellular localization nitrogen compound transport transport secretion organic substance transport protein secretion by the type III secretion system establishment of protein localization to extracellular region export from cell protein secretion establishment of localization protein localization to extracellular region transmembrane transport localization secretion by cell protein transmembrane transport protein transport cellular macromolecule localization macromolecule localization	-
C, F	Oxygen-regulated invasion protein OrgB,Endolysin	hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity hydrolase activity catalytic activity	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus organonitrogen compound catabolic process carbohydrate derivative catabolic process organonitrogen compound metabolic process biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus organonitrogen compound catabolic process carbohydrate derivative catabolic process organonitrogen compound metabolic process catabolic process peptidoglycan catabolic process glycosaminoglycan metabolic process carbohydrate derivative metabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process organic substance metabolic process aminoglycan metabolic process peptidoglycan metabolic process metabolic process macromolecule metabolic process organic substance catabolic process symbiont-mediated cytolysis of host cell viral life cycle disruption of cell in another organism cytolysis biological process involved in interaction with host biological process involved in symbiotic interaction viral release from host cell by cytolysis disruption of cellular anatomical structure in another organism exit from host cell viral process cytolysis in another organism cellular process viral release from host cell disruption of anatomical structure in another organism symbiont-mediated killing of host cell killing of cells of another organism cell killing disruption of plasma membrane integrity in another organism cell wall organization or biogenesis cell wall macromolecule catabolic process cell wall macromolecule metabolic process protein localization establishment of protein localization cellular localization nitrogen compound transport transport organic substance transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization	host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region cellular anatomical entity intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D	IPR003283	Type III secretion system outer membrane, SpaO	Family
A, D	IPR001543	Flagellar motor switch protein FliN-like, C-terminal domain	Domain
A, D	IPR036429	SpoA-like superfamily	Homologous Superfamily
A, D	IPR013385	Type III secretion system apparatus protein YscQ/HrcQ/SpaO	Family
B, E	IPR003283	Type III secretion system outer membrane, SpaO	Family
B, E	IPR001543	Flagellar motor switch protein FliN-like, C-terminal domain	Domain
B, E	IPR036429	SpoA-like superfamily	Homologous Superfamily
B, E	IPR013385	Type III secretion system apparatus protein YscQ/HrcQ/SpaO	Family
C, F	IPR001165	T4-type lysozyme	Family
C, F	IPR034690	Endolysin T4 type	Family
C, F	IPR002196	Glycoside hydrolase, family 24	Family
C, F	IPR023347	Lysozyme domain superfamily	Homologous Superfamily
C, F	IPR023346	Lysozyme-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.