Annotations: 4YOZ

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4yoza1	All alpha proteins	Cyclin-like	Cyclin-like	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d4yoza3	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01857	e4yozA2	A: alpha arrays	X: HTH	H: HTH	T: Cyclin-like	F: PF01857	ECOD (1.6)
A	PF01858	e4yozA1	A: alpha arrays	X: HTH	H: HTH	T: Cyclin-like	F: PF01858	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.472.10	Mainly Alpha	Orthogonal Bundle	Cyclin A	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01857	Retinoblastoma-associated protein B domain (RB_B)	Retinoblastoma-associated protein B domain	The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B domain [1]. The B dom ...	The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B domain [1]. The B domain has a cyclin fold.	Domain
A	PF01858	Retinoblastoma-associated protein A domain (RB_A)	Retinoblastoma-associated protein A domain	This domain has the cyclin fold [1] as predicted [2].	Domain
B	PF00527	E7 protein, Early protein (E7)	E7 protein, Early protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Retinoblastoma-like protein 1,Retinoblastoma-like protein 1	protein-containing complex binding chromatin binding binding promoter-specific chromatin binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription regulatory region nucleic acid binding	cellular process cell cycle developmental process cellular developmental process cell differentiation regulation of cell cycle phase transition regulation of cellular process negative regulation of biological process negative regulation of cell cycle cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle negative regulation of mitotic cell cycle cellular process cell cycle developmental process cellular developmental process cell differentiation regulation of cell cycle phase transition regulation of cellular process negative regulation of biological process negative regulation of cell cycle cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle negative regulation of cellular process negative regulation of cell cycle phase transition regulation of cell cycle cell cycle process negative regulation of G1/S transition of mitotic cell cycle regulation of biological process negative regulation of mitotic cell cycle phase transition regulation of cell cycle process negative regulation of cell cycle G1/S phase transition biological regulation negative regulation of cell cycle process regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle mitotic cell cycle phase transition cellular response to stimulus response to stimulus regulation of cellular senescence cellular metabolic process negative regulation of metabolic process cellular senescence regulation of cellular metabolic process negative regulation of cellular metabolic process negative regulation of cellular senescence cellular response to stress response to stress metabolic process regulation of metabolic process cellular biosynthetic process organic substance metabolic process organic substance biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II primary metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of catalytic activity phosphorylation regulation of transferase activity regulation of molecular function regulation of lipid kinase activity regulation of kinase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process regulation of phosphorylation regulation of phosphorus metabolic process phosphorus metabolic process protein-DNA complex organization cellular component organization protein-containing complex organization chromatin organization cellular component organization or biogenesis	protein-containing complex transcription regulator complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex transcription regulator complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle
B	HPV E7 peptide	DNA binding binding organic cyclic compound binding nucleic acid binding protein binding protein domain specific binding cation binding transition metal ion binding ion binding cadmium ion binding metal ion binding small molecule binding transcription factor binding DNA-binding transcription factor binding DNA binding binding organic cyclic compound binding nucleic acid binding protein binding protein domain specific binding cation binding transition metal ion binding ion binding cadmium ion binding metal ion binding small molecule binding transcription factor binding DNA-binding transcription factor binding transcription regulator activity DNA-binding transcription factor activity zinc ion binding	symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms modulation by symbiont of host process symbiont-mediated activation of of host transcription symbiont-mediated perturbation of host gene expression cellular process symbiont-mediated perturbation of host transcription modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction response to stimulus response to biotic stimulus symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms modulation by symbiont of host process symbiont-mediated activation of of host transcription symbiont-mediated perturbation of host gene expression cellular process symbiont-mediated perturbation of host transcription modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction response to stimulus response to biotic stimulus symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response response to host immune response symbiont-mediated suppression of host defenses symbiont-mediated perturbation of host innate immune response response to host response to external biotic stimulus symbiont-mediated perturbation of host signal transduction pathway symbiont-mediated perturbation of host defense response response to host defenses symbiont-mediated suppression of host JAK-STAT cascade symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host IRF9 activity response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism symbiont-mediated perturbation of host defenses response to external stimulus symbiont-mediated suppression of host signal transduction pathway positive regulation of organelle organization regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization regulation of actin filament-based process regulation of cellular component size positive regulation of biological process cellular component organization cellular component biogenesis regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly positive regulation of protein polymerization protein-containing complex assembly actin filament-based process cellular component organization or biogenesis regulation of actin filament polymerization regulation of biological quality positive regulation of cellular process protein polymerization actin polymerization or depolymerization regulation of biological process regulation of actin filament organization actin filament polymerization actin cytoskeleton organization protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization biological regulation actin filament organization regulation of actin polymerization or depolymerization positive regulation of supramolecular fiber organization regulation of cellular component biogenesis regulation of organelle organization organelle organization regulation of protein polymerization regulation of actin filament length regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization positive regulation of actin filament polymerization cytoskeleton organization regulation of anatomical structure size viral process symbiont-mediated suppression of host type I interferon-mediated signaling pathway symbiont-mediated suppression of host interferon-mediated signaling pathway symbiont-mediated perturbation of host cell cycle progression symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process organic substance metabolic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process macromolecule metabolic process	host intracellular membrane-bounded organelle host cellular component host intracellular part host cell part host intracellular region cellular anatomical entity host cell nucleus host intracellular organelle host cell cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002720	Retinoblastoma-associated protein, A-box	Domain
A	IPR024599	Retinoblastoma-associated protein, N-terminal	Domain
A	IPR028309	Retinoblastoma protein family	Family
A	IPR002719	Retinoblastoma-associated protein, B-box	Domain
A	IPR015030	Retinoblastoma-associated protein, C-terminal	Domain
A	IPR036915	Cyclin-like superfamily	Homologous Superfamily
A	IPR013763	Cyclin-like domain	Domain
B	IPR000148	Papillomavirus E7	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P28749	adrenal cortex carcinoma gastric cancer large cell medulloblastoma osteosarcoma tuberculosis atypical teratoid rhabdoid tumor gastric carcinoma malignant glioma pilocytic astrocytoma eye disease glioblastoma medulloblastoma primitive neuroectodermal tumor

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.