Annotations: 4YOM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth B]	d4yomb1	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	automated matches	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A [auth B]	d4yomb2	Artifacts	Tags	Tags	Tags	C-terminal Tags	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2 Family	MARK4 variant UBA domain-like	8067071	4007155	SCOP2 (2022-06-29)
A [auth B]	SCOP2 Family	Protein kinases catalytic domain-like	8084346	4003661	SCOP2 (2022-06-29)
A [auth B]	SCOP2 Superfamily	UBA-like	8090062	3001235	SCOP2 (2022-06-29)
A [auth B]	SCOP2 Superfamily	Protein kinase-like (PK-like)	8084347	3000066	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PF21115	e4yomB1	A: alpha arrays	X: RuvA-C	H: RuvA-C, UBA, CRAL/TRIO-N, HBS1 (From Topology)	T: RuvA-C, UBA, CRAL/TRIO-N, HBS1	F: PF21115	ECOD (1.6)
A [auth B]	PF00069	e4yomB2	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: PF00069	ECOD (1.6)
B [auth A]	PF21122	e4yomA1	A: a+b two layers	X: TBP-like	H: Kinase associated domain 1, KA1 (From Topology)	T: Kinase associated domain 1, KA1	F: PF21122	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
A [auth B]	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B]	PF21115	BRSK1/2 UBA domain (UBA_BRSK)	BRSK1/2 UBA domain	This entry represents a UBA domain found C-terminal to the kinase domain in the brain-specific kinases BRSK1 and BRSK2.	Domain
A [auth B]	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain
B [auth A]	PF21122	BRSK1/2 KA1 domain (KA1_BRSK)	BRSK1/2 KA1 domain	This entry represents the KA1-like domain found in the brain-specific kinases BRSK1 and BRSK2 [1-2]. The BRSK/SAD kinase family includes serine/threonine-protein kinases that play crucial roles in neuronal polarization, centrosome duplication, cell c ...	This entry represents the KA1-like domain found in the brain-specific kinases BRSK1 and BRSK2 [1-2]. The BRSK/SAD kinase family includes serine/threonine-protein kinases that play crucial roles in neuronal polarization, centrosome duplication, cell cycle progression, and insulin secretion. Members phosphorylate a variety of substrates including CDC25B, CDC25C, MAPT/TAU, and WEE1, modulating their activities. Activation by STK11/LKB1 is a common regulatory mechanism, leading to phosphorylation of microtubule-associated proteins and influencing neuron polarization. These kinases also contribute to synaptic vesicle function and neurotransmitter release, regulate the mitotic cell cycle, and respond to DNA damage. Additionally, they are involved in actin cytoskeleton reorganization and may play a role in the apoptotic response to endoplasmic reticulum stress.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	Serine/threonine-protein kinase BRSK2	tau-protein kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein serine kinase activity cation binding magnesium ion binding ion binding binding metal ion binding tau-protein kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein serine kinase activity cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding protein binding kinase binding enzyme binding protein kinase binding protein serine/threonine kinase activity ATPase binding	regulation of neuron projection development multicellular organismal process axonogenesis regulation of cellular component organization regulation of cellular process cellular developmental process regulation of developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development regulation of neuron projection development multicellular organismal process axonogenesis regulation of cellular component organization regulation of cellular process cellular developmental process regulation of developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis regulation of axonogenesis cell differentiation anatomical structure development cellular component organization or biogenesis regulation of anatomical structure morphogenesis system development developmental process regulation of biological process plasma membrane bounded cell projection organization regulation of cell projection organization biological regulation nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development cellular process regulation of plasma membrane bounded cell projection organization cellular response to stimulus response to organic substance catabolic process response to stimulus proteolysis involved in protein catabolic process macromolecule catabolic process ERAD pathway organic substance metabolic process cellular response to stress response to stress proteolysis protein metabolic process response to endoplasmic reticulum stress organonitrogen compound catabolic process organonitrogen compound metabolic process response to organonitrogen compound response to nitrogen compound proteasomal protein catabolic process primary metabolic process protein catabolic process response to chemical metabolic process macromolecule metabolic process organic substance catabolic process cell division protein localization regulation of localization establishment of protein localization nitrogen compound transport cell communication localization carbohydrate homeostasis cellular macromolecule localization establishment of localization in cell regulation of biological quality regulation of peptide hormone secretion regulation of hormone levels organic substance transport establishment of protein localization to extracellular region intracellular glucose homeostasis protein secretion establishment of localization cellular response to oxygen-containing compound regulation of protein secretion regulation of secretion cellular response to carbohydrate stimulus chemical homeostasis response to glucose glucose homeostasis insulin secretion involved in cellular response to glucose stimulus cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion transport signaling homeostatic process hormone secretion protein localization to extracellular region peptide secretion secretion by cell regulation of secretion by cell response to monosaccharide response to carbohydrate amide transport signal release cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus cellular response to organic substance regulation of signaling secretion regulation of transport regulation of peptide transport regulation of establishment of protein localization cell-cell signaling export from cell response to oxygen-containing compound cellular response to glucose stimulus regulation of protein transport peptide transport response to hexose cellular response to chemical stimulus cellular homeostasis protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization regulation of insulin secretion involved in cellular response to glucose stimulus hormone transport regulation of cell communication insulin secretion establishment of cell polarity establishment or maintenance of cell polarity organelle organization actin cytoskeleton organization actin filament-based process cytoskeleton organization protein phosphorylation phosphorylation cellular metabolic process macromolecule modification phosphate-containing compound metabolic process protein modification process phosphorus metabolic process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cell death intracellular signal transduction apoptotic signaling pathway signal transduction apoptotic process intrinsic apoptotic signaling pathway programmed cell death exocytosis vesicle-mediated transport cell cycle G2/M phase transition mitotic cell cycle process G2/M transition of mitotic cell cycle cell cycle phase transition cell cycle mitotic cell cycle cell cycle process mitotic cell cycle phase transition establishment of planar polarity epithelium development microtubule cytoskeleton organization morphogenesis of an epithelium tissue development microtubule cytoskeleton organization involved in establishment of planar polarity tissue morphogenesis establishment of tissue polarity morphogenesis of a polarized epithelium microtubule-based process	intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle axon cell projection distal axon neuron projection intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle axon cell projection distal axon neuron projection plasma membrane bounded cell projection perinuclear region of cytoplasm cytoplasm membrane-bounded organelle endoplasmic reticulum intracellular membrane-bounded organelle endomembrane system
B [auth A]	Serine/threonine-protein kinase BRSK2	tau-protein kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein serine kinase activity cation binding magnesium ion binding ion binding binding metal ion binding tau-protein kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein serine kinase activity cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding protein binding kinase binding enzyme binding protein kinase binding protein serine/threonine kinase activity ATPase binding	regulation of neuron projection development multicellular organismal process axonogenesis regulation of cellular component organization regulation of cellular process cellular developmental process regulation of developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development regulation of neuron projection development multicellular organismal process axonogenesis regulation of cellular component organization regulation of cellular process cellular developmental process regulation of developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis regulation of axonogenesis cell differentiation anatomical structure development cellular component organization or biogenesis regulation of anatomical structure morphogenesis system development developmental process regulation of biological process plasma membrane bounded cell projection organization regulation of cell projection organization biological regulation nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development cellular process regulation of plasma membrane bounded cell projection organization cellular response to stimulus response to organic substance catabolic process response to stimulus proteolysis involved in protein catabolic process macromolecule catabolic process ERAD pathway organic substance metabolic process cellular response to stress response to stress proteolysis protein metabolic process response to endoplasmic reticulum stress organonitrogen compound catabolic process organonitrogen compound metabolic process response to organonitrogen compound response to nitrogen compound proteasomal protein catabolic process primary metabolic process protein catabolic process response to chemical metabolic process macromolecule metabolic process organic substance catabolic process cell division protein localization regulation of localization establishment of protein localization nitrogen compound transport cell communication localization carbohydrate homeostasis cellular macromolecule localization establishment of localization in cell regulation of biological quality regulation of peptide hormone secretion regulation of hormone levels organic substance transport establishment of protein localization to extracellular region intracellular glucose homeostasis protein secretion establishment of localization cellular response to oxygen-containing compound regulation of protein secretion regulation of secretion cellular response to carbohydrate stimulus chemical homeostasis response to glucose glucose homeostasis insulin secretion involved in cellular response to glucose stimulus cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion transport signaling homeostatic process hormone secretion protein localization to extracellular region peptide secretion secretion by cell regulation of secretion by cell response to monosaccharide response to carbohydrate amide transport signal release cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus cellular response to organic substance regulation of signaling secretion regulation of transport regulation of peptide transport regulation of establishment of protein localization cell-cell signaling export from cell response to oxygen-containing compound cellular response to glucose stimulus regulation of protein transport peptide transport response to hexose cellular response to chemical stimulus cellular homeostasis protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization regulation of insulin secretion involved in cellular response to glucose stimulus hormone transport regulation of cell communication insulin secretion establishment of cell polarity establishment or maintenance of cell polarity organelle organization actin cytoskeleton organization actin filament-based process cytoskeleton organization protein phosphorylation phosphorylation cellular metabolic process macromolecule modification phosphate-containing compound metabolic process protein modification process phosphorus metabolic process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cell death intracellular signal transduction apoptotic signaling pathway signal transduction apoptotic process intrinsic apoptotic signaling pathway programmed cell death exocytosis vesicle-mediated transport cell cycle G2/M phase transition mitotic cell cycle process G2/M transition of mitotic cell cycle cell cycle phase transition cell cycle mitotic cell cycle cell cycle process mitotic cell cycle phase transition establishment of planar polarity epithelium development microtubule cytoskeleton organization morphogenesis of an epithelium tissue development microtubule cytoskeleton organization involved in establishment of planar polarity tissue morphogenesis establishment of tissue polarity morphogenesis of a polarized epithelium microtubule-based process	intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle axon cell projection distal axon neuron projection intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle axon cell projection distal axon neuron projection plasma membrane bounded cell projection perinuclear region of cytoplasm cytoplasm membrane-bounded organelle endoplasmic reticulum intracellular membrane-bounded organelle endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B]	IPR017441	Protein kinase, ATP binding site	Binding Site
A [auth B]	IPR000719	Protein kinase domain	Domain
A [auth B]	IPR048622	BRSK1/2-like, UBA domain	Domain
A [auth B]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A [auth B]	IPR008271	Serine/threonine-protein kinase, active site	Active Site
B [auth A]	IPR017441	Protein kinase, ATP binding site	Binding Site
B [auth A]	IPR000719	Protein kinase domain	Domain
B [auth A]	IPR048622	BRSK1/2-like, UBA domain	Domain
B [auth A]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B [auth A]	IPR008271	Serine/threonine-protein kinase, active site	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.