4XX1

Low resolution structure of LCAT in complex with Fab1

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth L]	PF07654	e4xx1L1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
A [auth L]	PF07686	e4xx1L2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
D [auth G]	PF07654	e4xx1G1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
D [auth G]	PF07686	e4xx1G2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
G [auth O]	PF07686	e4xx1O1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
B [auth H]	PF07654	e4xx1H2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
B [auth H]	PF07686	e4xx1H1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
E	PF07654	e4xx1E2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
E	PF07686	e4xx1E1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
H [auth M]	PF07686	e4xx1M1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
C [auth A]	PF02450	e4xx1A1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: PF02450	ECOD (1.6)
F [auth B]	PF02450	e4xx1B1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: PF02450	ECOD (1.6)
I [auth J]	PF02450	e4xx1J1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: PF02450	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth L]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D [auth G]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
G [auth O]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B [auth H]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
H [auth M]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C [auth A]	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
F [auth B]	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
I [auth J]	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A [auth L], D [auth G], G [auth O]	Light Chain	IGLV3	Lambda	phosphatidylcholine-sterol acyltransferase	SAbDab (2024-05-31)
B [auth H], E, H [auth M]	Heavy Chain	IGHV3	-	phosphatidylcholine-sterol acyltransferase	SAbDab (2024-05-31)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A], F [auth B], I [auth J]	PF02450	Lecithin:cholesterol acyltransferase (LCAT)	Lecithin:cholesterol acyltransferase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth L], D [auth G], G [auth O]	Fab1 light chain	-	-	-
B [auth H], E, H [auth M]	Fab1 heavy chain	-	-	-
C [auth A], F [auth B], I [auth J]	Phosphatidylcholine-sterol acyltransferase	hydrolase activity, acting on ester bonds sterol esterase activity carboxylic ester hydrolase activity hydrolase activity catalytic activity lipase activity O-acyltransferase activity phosphatidylcholine-sterol O-acyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity 1-alkyl-2-acetylglycerophosphocholine esterase activity apolipoprotein binding protein binding hydrolase activity, acting on ester bonds sterol esterase activity carboxylic ester hydrolase activity hydrolase activity catalytic activity lipase activity O-acyltransferase activity phosphatidylcholine-sterol O-acyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity 1-alkyl-2-acetylglycerophosphocholine esterase activity apolipoprotein binding protein binding binding apolipoprotein A-I binding platelet-activating factor acetyltransferase activity acetyltransferase activity	organonitrogen compound metabolic process cellular biosynthetic process lipoprotein biosynthetic process cellular metabolic process lipoprotein metabolic process organonitrogen compound biosynthetic process primary metabolic process macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process macromolecule metabolic process organonitrogen compound metabolic process cellular biosynthetic process lipoprotein biosynthetic process cellular metabolic process lipoprotein metabolic process organonitrogen compound biosynthetic process primary metabolic process macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process macromolecule metabolic process protein metabolic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process phosphate-containing compound metabolic process phosphatidylcholine metabolic process phosphorus metabolic process glycerophospholipid biosynthetic process phospholipid biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process glycerolipid metabolic process phosphatidylcholine biosynthetic process lipid metabolic process transport organic substance transport reverse cholesterol transport lipid localization lipid transport organic hydroxy compound transport establishment of localization localization macromolecule localization cholesterol transport sterol transport plasma lipoprotein particle organization multicellular organismal process regulation of biological process protein-containing complex organization protein-containing complex remodeling protein-lipid complex organization biological regulation plasma lipoprotein particle remodeling regulation of plasma lipoprotein particle levels cellular component organization high-density lipoprotein particle remodeling protein-lipid complex remodeling cellular component organization or biogenesis triglyceride-rich lipoprotein particle remodeling very-low-density lipoprotein particle remodeling sterol homeostasis chemical homeostasis homeostatic process cholesterol homeostasis lipid homeostasis organic hydroxy compound metabolic process sterol metabolic process steroid metabolic process cholesterol metabolic process alcohol metabolic process organic cyclic compound metabolic process secondary alcohol metabolic process small molecule metabolic process regulation of cellular process regulation of cellular component organization regulation of high-density lipoprotein particle assembly regulation of cellular component biogenesis cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly high-density lipoprotein particle assembly protein-containing complex assembly regulation of multicellular organismal process plasma lipoprotein particle assembly protein-lipid complex assembly	extracellular region cellular anatomical entity protein-containing complex plasma lipoprotein particle high-density lipoprotein particle extracellular space lipoprotein particle protein-lipid complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular region cellular anatomical entity protein-containing complex plasma lipoprotein particle high-density lipoprotein particle extracellular space lipoprotein particle protein-lipid complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A], F [auth B], I [auth J]	IPR003386	Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase	Family
C [auth A], F [auth B], I [auth J]	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth A], F [auth B], I [auth J]	Pharos: P04180	Norum disease fish eye disease astrocytic tumor glioblastoma hypolipoproteinemia malignant ependymoma pancreatic ductal adenocarcinoma cataract hepatocellular carcinoma inborn errors of metabolism metabolic syndrome X oligodendroglioma pilocytic astrocytoma Hypercholesterolemia, Familial non-small cell lung carcinoma Norum disease fish eye disease astrocytic tumor glioblastoma hypolipoproteinemia malignant ependymoma pancreatic ductal adenocarcinoma cataract hepatocellular carcinoma inborn errors of metabolism metabolic syndrome X oligodendroglioma pilocytic astrocytoma Hypercholesterolemia, Familial non-small cell lung carcinoma ovarian cancer primary biliary cholangitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.