4XL1
Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF1)
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d4xl1a1 | Small proteins | Knottins (small inhibitors, toxins, lectins) | EGF/Laminin | automated matches | automated matches | Rat (Rattus norvegicus ) [TaxId: 10116 ], | SCOPe (2.08) |
A | d4xl1a4 | Artifacts | Tags | Tags | Tags | C-terminal Tags | Rat (Rattus norvegicus ) [TaxId: 10116 ], | SCOPe (2.08) |
C [auth D] | d4xl1d1 | Small proteins | Knottins (small inhibitors, toxins, lectins) | EGF/Laminin | automated matches | automated matches | Rat (Rattus norvegicus ) [TaxId: 10116 ], | SCOPe (2.08) |
C [auth D] | d4xl1d5 | Artifacts | Tags | Tags | Tags | C-terminal Tags | Rat (Rattus norvegicus ) [TaxId: 10116 ], | SCOPe (2.08) |
C [auth D] | d4xl1d4 | Artifacts | Tags | Tags | Tags | N-terminal Tags | Rat (Rattus norvegicus ) [TaxId: 10116 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF00008 | e4xl1A2 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: EGF/Laminin | F: PF00008 | ECOD (1.6) |
A | PF07645 | e4xl1A1 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: EGF/Laminin | F: PF07645 | ECOD (1.6) |
C [auth D] | PF00008 | e4xl1D1 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: EGF/Laminin | F: PF00008 | ECOD (1.6) |
C [auth D] | PF07645 | e4xl1D3 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: EGF/Laminin | F: PF07645 | ECOD (1.6) |
B | PF07657 | e4xl1B3 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: C2 domain (From Topology) | T: C2 domain | F: PF07657 | ECOD (1.6) |
B | PF01414 | e4xl1B2 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: EGF/Laminin | F: PF01414 | ECOD (1.6) |
B | PF21700 | e4xl1B1 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: EGF/Laminin | F: PF21700 | ECOD (1.6) |
D [auth E] | PF07657 | e4xl1E2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: C2 domain (From Topology) | T: C2 domain | F: PF07657 | ECOD (1.6) |
D [auth E] | PF01414 | e4xl1E3 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: EGF/Laminin | F: PF01414 | ECOD (1.6) |
D [auth E] | PF21700 | e4xl1E1 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: EGF/Laminin | F: PF21700 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 2.10.25.10 | Mainly Beta | Ribbon | Laminin | Laminin | CATH (4.3.0) |
C [auth D] | 2.10.25.10 | Mainly Beta | Ribbon | Laminin | Laminin | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A, C [auth D] | PF00008 | EGF-like domain (EGF) | EGF-like domain | There is no clear separation between noise and signal. Pfam:PF00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is t ... | Domain |
A, C [auth D] | PF12661 | Human growth factor-like EGF (hEGF) | Human growth factor-like EGF | hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteristic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selec ... | Domain |
A, C [auth D] | PF07645 | Calcium-binding EGF domain (EGF_CA) | Calcium-binding EGF domain | - | Domain |
B, D [auth E] | PF01414 | Delta serrate ligand (DSL) | Delta serrate ligand | This family has been redefined to correspond to the EGF-like domain defined by structure. | Domain |
B, D [auth E] | PF07657 | N terminus of Notch ligand C2-like domain (MNNL) | N terminus of Notch ligand C2-like domain | This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins. The entry has been extended to correspond to the C2-like domain defined by the protein structure. | Domain |