Annotations: 4XA3

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF03271	e4xa3A2	A: alpha duplicates or obligate multimers	X: EB1 dimerisation domain-like (From Topology)	H: EB1 dimerisation domain-like (From Topology)	T: EB1 dimerisation domain-like	F: PF03271	ECOD (1.6)
B	PF03271	e4xa3B2	A: alpha duplicates or obligate multimers	X: EB1 dimerisation domain-like (From Topology)	H: EB1 dimerisation domain-like (From Topology)	T: EB1 dimerisation domain-like	F: PF03271	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03271	EB1-like C-terminal motif (EB1)	EB1-like C-terminal motif	-	Family
A, B	PF11418	Phi29 scaffolding protein (Scaffolding_pro)	Phi29 scaffolding protein	-	Family
A, B	PF01576	Myosin tail (Myosin_tail_1)	Myosin tail	-	Coiled-coil

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Gp7-MYH7(1361-1425)-Eb1 chimera protein	DNA binding binding organic cyclic compound binding nucleic acid binding RNA binding protein binding kinase binding enzyme binding protein kinase binding cell adhesion molecule binding cadherin binding molecular adaptor activity cytoskeletal protein binding microtubule plus-end binding DNA binding binding organic cyclic compound binding nucleic acid binding RNA binding protein binding kinase binding enzyme binding protein kinase binding cell adhesion molecule binding cadherin binding molecular adaptor activity cytoskeletal protein binding microtubule plus-end binding microtubule binding tubulin binding identical protein binding actin binding protein-containing complex binding actin filament binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding calmodulin binding cytoskeletal motor activity microfilament motor activity ATP-dependent activity	virion assembly viral process viral life cycle cellular component organization microtubule bundle formation organelle organization microtubule cytoskeleton organization cellular process microtubule-based process cellular component organization or biogenesis cytoskeleton organization protein localization localization cellular localization virion assembly viral process viral life cycle cellular component organization microtubule bundle formation organelle organization microtubule cytoskeleton organization cellular process microtubule-based process cellular component organization or biogenesis cytoskeleton organization protein localization localization cellular localization cellular macromolecule localization macromolecule localization protein localization to microtubule cytoskeleton protein localization to microtubule organizing center protein localization to cytoskeleton protein localization to organelle protein localization to centrosome regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization regulation of cellular component organization regulation of cellular process negative regulation of biological process cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly microtubule polymerization or depolymerization negative regulation of cellular process protein-containing complex assembly negative regulation of protein polymerization negative regulation of supramolecular fiber organization protein polymerization regulation of biological process negative regulation of cellular component organization negative regulation of microtubule polymerization or depolymerization protein-containing complex organization negative regulation of cytoskeleton organization biological regulation regulation of microtubule-based process negative regulation of microtubule polymerization microtubule polymerization regulation of cellular component biogenesis regulation of organelle organization negative regulation of protein-containing complex assembly negative regulation of organelle organization regulation of protein polymerization regulation of microtubule polymerization regulation of supramolecular fiber organization supramolecular fiber organization regulation of microtubule cytoskeleton organization establishment of organelle localization mitotic metaphase chromosome alignment mitotic cell cycle metaphase chromosome alignment chromosome localization organelle localization establishment of localization in cell mitotic sister chromatid segregation cell cycle chromosome segregation cell cycle process mitotic nuclear division attachment of spindle microtubules to kinetochore organelle fission attachment of mitotic spindle microtubules to kinetochore chromosome organization sister chromatid segregation establishment of localization nuclear division mitotic cell cycle process nuclear chromosome segregation establishment of chromosome localization cell division cell migration cell motility organelle assembly non-membrane-bounded organelle assembly spindle assembly spindle organization plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cilium assembly non-motile cilium assembly cilium organization cell projection assembly protein localization to astral microtubule protein localization to microtubule protein localization to cytoplasmic microtubule protein localization to spindle microtubule spindle localization establishment or maintenance of cell polarity establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation microtubule cytoskeleton organization involved in mitosis establishment of cell polarity establishment of mitotic spindle orientation positive regulation of organelle organization positive regulation of cellular component organization positive regulation of biological process positive regulation of protein-containing complex assembly positive regulation of protein polymerization positive regulation of cellular process positive regulation of microtubule polymerization or depolymerization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization positive regulation of supramolecular fiber organization positive regulation of microtubule polymerization heart process multicellular organismal process system process regulation of heart contraction regulation of system process circulatory system process regulation of blood circulation regulation of multicellular organismal process regulation of biological quality heart contraction blood circulation regulation of heart rate muscle contraction muscle system process striated muscle contraction ribose phosphate metabolic process ATP metabolic process carbohydrate derivative metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process organic substance metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process purine nucleoside triphosphate metabolic process organonitrogen compound metabolic process cellular metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process organic cyclic compound metabolic process organophosphate metabolic process metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process regulation of the force of heart contraction regulation of muscle adaptation striated muscle adaptation response to stimulus transition between fast and slow fiber regulation of skeletal muscle adaptation regulation of muscle system process muscle adaptation regulation of response to stimulus skeletal muscle adaptation slow-twitch skeletal muscle fiber contraction twitch skeletal muscle contraction multicellular organismal movement musculoskeletal movement regulation of twitch skeletal muscle contraction regulation of skeletal muscle contraction regulation of slow-twitch skeletal muscle fiber contraction nervous system process neuromuscular process skeletal muscle contraction voluntary skeletal muscle contraction regulation of striated muscle contraction regulation of muscle contraction muscle filament sliding actin filament-based process actin-mediated cell contraction actin filament-based movement actin-myosin filament sliding cardiac muscle contraction developmental process heart development multicellular organism development anatomical structure development animal organ development adult heart development circulatory system development system development ventricular cardiac muscle tissue morphogenesis heart morphogenesis striated muscle tissue development muscle structure development ventricular cardiac muscle tissue development cardiac chamber development animal organ morphogenesis muscle tissue development muscle organ development cardiac chamber morphogenesis cardiac muscle tissue development tissue development muscle tissue morphogenesis anatomical structure morphogenesis tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis cardiac ventricle development muscle organ morphogenesis regulation of the force of skeletal muscle contraction regulation of skeletal muscle contraction by chemo-mechanical energy conversion cellular developmental process cellular component assembly involved in morphogenesis cell development muscle cell differentiation striated muscle cell development cellular anatomical entity morphogenesis muscle cell development cell differentiation sarcomere organization actomyosin structure organization actin cytoskeleton organization myofibril assembly anatomical structure formation involved in morphogenesis striated muscle cell differentiation muscle hypertrophy striated muscle hypertrophy cardiac muscle adaptation response to stress cardiac muscle hypertrophy cardiac muscle hypertrophy in response to stress muscle hypertrophy in response to stress	protein-containing complex viral capsid virion component viral scaffold anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle protein-containing complex viral capsid virion component viral scaffold anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle midzone microtubule cytoskeleton non-membrane-bounded organelle centrosome microtubule organizing center polymeric cytoskeletal fiber mitotic spindle aster spindle microtubule cytoplasmic microtubule mitotic spindle astral microtubule end supramolecular polymer supramolecular complex microtubule end mitotic spindle astral microtubule astral microtubule supramolecular fiber cytoplasm microtubule microtubule plus-end cytosol cell periphery cell projection membrane plasma membrane plasma membrane region cell projection membrane plasma membrane bounded cell projection membrane-bounded organelle Golgi apparatus intracellular membrane-bounded organelle endomembrane system cell cortex cortical cytoskeleton cortical microtubule cytoskeleton mitotic spindle pole spindle pole cilium ciliary basal body Z disc sarcomere I band contractile muscle fiber myofibril actin cytoskeleton myosin complex myosin II complex muscle myosin complex myosin filament actin filament bundle actomyosin stress fiber contractile actin filament bundle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR038032	Capsid assembly scaffolding protein Gp7	Homologous Superfamily
A, B	IPR024374	Bacteriophage phi-29 scaffolding protein Gp7	Family
A, B	IPR001715	Calponin homology domain	Domain
A, B	IPR004953	EB1, C-terminal	Domain
A, B	IPR027328	Microtubule-associated protein RP/EB	Family
A, B	IPR036133	EB1, C-terminal domain superfamily	Homologous Superfamily
A, B	IPR036872	CH domain superfamily	Homologous Superfamily
A, B	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A, B	IPR000048	IQ motif, EF-hand binding site	Binding Site
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR014751	DNA repair protein XRCC4-like, C-terminal	Homologous Superfamily
A, B	IPR001609	Myosin head, motor domain	Domain
A, B	IPR002928	Myosin tail	Domain
A, B	IPR004009	Myosin, N-terminal, SH3-like	Domain
A, B	IPR008989	Myosin S1 fragment, N-terminal	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P12883	Weight Gain primitive neuroectodermal tumor astrocytic tumor coronary artery disease inflammatory bowel disease lymphoplasmacytic lymphoma medulloblastoma oligodendroglioma plasma cell myeloma atypical teratoid rhabdoid tumor dermatomyositis juvenile dermatomyositis malignant ependymoma myocardial ischemia osteosarcoma Weight Gain primitive neuroectodermal tumor astrocytic tumor coronary artery disease inflammatory bowel disease lymphoplasmacytic lymphoma medulloblastoma oligodendroglioma plasma cell myeloma atypical teratoid rhabdoid tumor dermatomyositis juvenile dermatomyositis malignant ependymoma myocardial ischemia osteosarcoma polycystic ovary syndrome breast carcinoma glioblastoma large cell medulloblastoma malignant glioma nicotine dependence ovarian cancer myopathy, myosin storage, autosomal dominant dilated cardiomyopathy myopathy, myosin storage, autosomal recessive hypertrophic cardiomyopathy left ventricular noncompaction congenital fiber-type disproportion myopathy dilated cardiomyopathy 1S MYH7-related skeletal myopathy distal myopathy Ebstein anomaly hypertrophic cardiomyopathy 1 cardiomyopathy myocardial infarction tibial muscular dystrophy congenital structural myopathy atrial fibrillation MYH7-related late-onset scapuloperoneal muscular dystrophy centronuclear myopathy coronary stenosis familial dilated cardiomyopathy heart disease arthrogryposis LEFT VENTRICULAR NONCOMPACTION 5 autosomal dominant centronuclear myopathy scapuloperoneal myopathy Charcot-Marie-Tooth disease familial hypertrophic cardiomyopathy hyaline body myopathy malignant ependymoma psoriasis X-linked centronuclear myopathy dilated cardiomyopathy 1A familial isolated dilated cardiomyopathy autosomal recessive centronuclear myopathy myopathy myotonia congenita restrictive cardiomyopathy tubular aggregate myopathy X-linked Emery-Dreifuss muscular dystrophy

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.