4URR

Tailspike protein of Sf6 bacteriophage bound to Shigella flexneri O- antigen octasaccharide fragment

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF21519	e4urrA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Ig-like domain in tailspike protein (From Topology)	T: Ig-like domain in tailspike protein	F: PF21519	ECOD (1.6)
A	F_UNCLASSIFIED	e4urrA1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Pectin lyase-like (From Topology)	T: Pectin lyase-like	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF21519	e4urrB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Ig-like domain in tailspike protein (From Topology)	T: Ig-like domain in tailspike protein	F: PF21519	ECOD (1.6)
B	F_UNCLASSIFIED	e4urrB2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Pectin lyase-like (From Topology)	T: Pectin lyase-like	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF21519	e4urrC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Ig-like domain in tailspike protein (From Topology)	T: Ig-like domain in tailspike protein	F: PF21519	ECOD (1.6)
C	F_UNCLASSIFIED	e4urrC1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Pectin lyase-like (From Topology)	T: Pectin lyase-like	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF21519	e4urrD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Ig-like domain in tailspike protein (From Topology)	T: Ig-like domain in tailspike protein	F: PF21519	ECOD (1.6)
D	F_UNCLASSIFIED	e4urrD2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Pectin lyase-like (From Topology)	T: Pectin lyase-like	F: F_UNCLASSIFIED	ECOD (1.6)
E	PF21519	e4urrE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Ig-like domain in tailspike protein (From Topology)	T: Ig-like domain in tailspike protein	F: PF21519	ECOD (1.6)
E	F_UNCLASSIFIED	e4urrE2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Pectin lyase-like (From Topology)	T: Pectin lyase-like	F: F_UNCLASSIFIED	ECOD (1.6)
F	PF21519	e4urrF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Ig-like domain in tailspike protein (From Topology)	T: Ig-like domain in tailspike protein	F: PF21519	ECOD (1.6)
F	F_UNCLASSIFIED	e4urrF2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Pectin lyase-like (From Topology)	T: Pectin lyase-like	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.160.20.10	Mainly Beta	3 Solenoid	Pectate Lyase C-like	Single-stranded right-handed beta-helix, Pectin lyase-like	CATH (4.3.0)
B	2.160.20.10	Mainly Beta	3 Solenoid	Pectate Lyase C-like	Single-stranded right-handed beta-helix, Pectin lyase-like	CATH (4.3.0)
C	2.160.20.10	Mainly Beta	3 Solenoid	Pectate Lyase C-like	Single-stranded right-handed beta-helix, Pectin lyase-like	CATH (4.3.0)
D	2.160.20.10	Mainly Beta	3 Solenoid	Pectate Lyase C-like	Single-stranded right-handed beta-helix, Pectin lyase-like	CATH (4.3.0)
E	2.160.20.10	Mainly Beta	3 Solenoid	Pectate Lyase C-like	Single-stranded right-handed beta-helix, Pectin lyase-like	CATH (4.3.0)
F	2.160.20.10	Mainly Beta	3 Solenoid	Pectate Lyase C-like	Single-stranded right-handed beta-helix, Pectin lyase-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF21519	Tailspike protein, C-terminal (Tailspike_C)	Tailspike protein, C-terminal	Tailspike protein from Shigella phage Sf6 specifically mediates the attachment to their hosts. Its structure revealed a conserved architecture with a central, right-handed beta-helix. The C-terminal domain adopts a beta-sandwich fold, is represented ...	Tailspike protein from Shigella phage Sf6 specifically mediates the attachment to their hosts. Its structure revealed a conserved architecture with a central, right-handed beta-helix. The C-terminal domain adopts a beta-sandwich fold, is represented in this entry, and is reminiscent of viral capsid proteins [1,2].	Domain
A, B, C, D, E A, B, C, D, E, F	PF12708	Pectate lyase superfamily protein (Pectate_lyase_3)	Pectate lyase superfamily protein	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	BIFUNCTIONAL TAIL PROTEIN	hydrolase activity, acting on glycosyl bonds endo-1,3-alpha-L-rhamnosidase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity	virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral process viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated disruption of host anatomical structure symbiont entry into host cell via disruption of host cell envelope lipopolysaccharide disruption of cell wall in another organism symbiont-mediated disruption of host cell wall symbiont-mediated disruption of host cell envelope disruption of cellular anatomical structure in another organism virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral process viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated disruption of host anatomical structure symbiont entry into host cell via disruption of host cell envelope lipopolysaccharide disruption of cell wall in another organism symbiont-mediated disruption of host cell wall symbiont-mediated disruption of host cell envelope disruption of cellular anatomical structure in another organism symbiont-mediated disruption of host cellular anatomical entity symbiont entry into host cell symbiont entry into host disruption of anatomical structure in another organism metabolic process symbiont entry into host cell via disruption of host cell envelope	virus tail, fiber virus tail virion component

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR012334	Pectin lyase fold	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR036730	Phage P22 tailspike-like, N-terminal domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR049104	Tail spike protein-like, C-terminal domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR024535	Pectate lyase superfamily protein	Domain
A, B, C, D, E A, B, C, D, E, F	IPR009093	Bacteriophage P22 tailspike, N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR011050	Pectin lyase fold/virulence factor	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.